Results 71 to 80 of about 14,256 (219)

Electrophysiology of Sodium Receptors in Taste Cells [PDF]

, 2016
Sodium intake is important to maintain proper osmolarity and volume of extracellular fluid in vertebrates. The ability to find sources of sodium ions for managing electrolyte homeostasis relies on the activity of the taste system to sense salt.
Bigiani, Albertino
core   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Activation by cleavage of the epithelial Na+ channel α and γ subunits independently coevolved with the vertebrate terrestrial migration

eLife, 2022
Vertebrates evolved mechanisms for sodium conservation and gas exchange in conjunction with migration from aquatic to terrestrial habitats. Epithelial Na+ channel (ENaC) function is critical to systems responsible for extracellular fluid homeostasis and ...
Xue-Ping Wang, Deidra M Balchak, Clayton Gentilcore, Nathan L Clark, Ossama B Kashlan   +4 more
doaj   +1 more source

Branchial localization of acid (A‐type) and base (B‐type) excreting ionocytes in Amazonian stenohaline freshwater Potamotrygon ray

Journal of Fish Biology, EarlyView.
Abstract The branchial epithelium of Potamotrygon—a member of the only strictly freshwater elasmobranch family Potamotrygonidae—was observed via immunohistochemistry, and two distinct forms of ionocytes were identified. The acid (A‐type) and base (B‐type) secreting cells with respective basolateral–apical localizations of Na+/K+‐ATPase–Na+/H+ exchanger
M. W. Rossi, C. M. Wood, A. L. Val, J. M. Wilson   +3 more
wiley   +1 more source

Distinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium channel (ENaC) currents in HT-29 colonic epithelial cells

International Journal of Biological Sciences, 2007
The amiloride-sensitive epithelial sodium channel (ENaC), a plasma membrane protein mediates sodium reabsorption in epithelial tissues, including the distal nephron and colon.
Sunil K Saxena, Madhurima Singh, Simarna Kaur, Constantine George
doaj  

a therapeutic strategy for cystic fibrosis [PDF]

, 2017
The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and mucociliary function.
Aldossary, Ahmad M., Attwood, Martin, Barnes, Josephine L., Hart, Stephen L., Manunta, Maria D. I., McAnulty, Robin J., Munye, Mustafa M., Tagalakis, Aristides D., Weng, Alexander   +8 more
core   +1 more source

Detection of renal tubular transporter proteins in canine urinary extracellular vesicles using liquid chromatography–tandem mass spectrometry

Veterinary Clinical Pathology, EarlyView.
Abstract Urinary extracellular vesicles (UEVs) are membranous particles that carry renal tubular transporter proteins. Here, we evaluate whether selected renal tubular transporter proteins can be detected in UEVs isolated from small volume (1–5 mL) canine urine samples of healthy dogs and canine patients with elevated circulating parathyroid hormone ...
L. J. McGravey, P. R. Antrobus, T. L. Williams   +2 more
wiley   +1 more source

Sodium–glucose cotransporter 2 inhibitors for hypertension in cardiovascular–kidney–metabolic syndrome

Experimental Physiology, EarlyView.
Abstract The antihypertensive mechanism of sodium–glucose cotransporter 2 (SGLT2) inhibitors has been traditionally attributed to osmotic diuresis. However, emerging evidence reveals multifaceted mechanisms beyond diuresis, including regulation of the renin–angiotensin–aldosterone system, sympathetic nervous system suppression, ion homeostasis ...
Chunxiang Xu, Xingyu Qiu, Nan Xu, Gensheng Zhang, Enyin Lai, Liang Zhao   +5 more
wiley   +1 more source

Hormonal Regulation of the Epithelial Sodium Channel ENaC [PDF]

The Journal of General Physiology, 2002
Despite large changes in water and salt intake, the kidney is able to maintain the extracellular osmolarity and volume within narrow margins (Verrey et al., 2000). Such fine control requires specific factors or hormones; among them, aldosterone and antidiuretic hormone (ADH) (vasopressin in mammals) play the key role.
openaire   +3 more sources

The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19. [PDF]

, 2016
Acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC) are both members of the ENaC/degenerin family of amiloride-sensitive Na(+) channels.
Alijevic, O., Boscardin, E., Frateschi, S., Hummler, E., Kellenberger, S.   +4 more
core   +1 more source