Results 81 to 90 of about 14,256 (219)

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source

The endothelial αENaC contributes to vascular endothelial function in vivo. [PDF]

PLoS ONE, 2017
The Epithelial Sodium Channel (ENaC) is a key player in renal sodium homeostasis. The expression of α β γ ENaC subunits has also been described in the endothelium and vascular smooth muscle, suggesting a role in vascular function.
Antoine Tarjus, Martina Maase, Pia Jeggle, Ernesto Martinez-Martinez, Céline Fassot, Laurent Loufrani, Daniel Henrion, Pernille B L Hansen, Kristina Kusche-Vihrog, Frederic Jaisser   +9 more
doaj   +1 more source

Ion channels: structural basis for function and disease. [PDF]

, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Non‐Invasive, High‐Resolution (1H2O) Metabolic Activity Diffusion Imaging [MADI] of Rat Glioma

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
We employed Metabolic Activity Diffusion Imaging [MADI] and 18FDG‐PET in rats with syngeneic RG2 glioblastoma brain tumors. MADI quantifies kio (the cellular H2O efflux rate constant), cell volume (V), and cell density (ρ), without the use of contrast agents. The kioV product quantifies the rate of water efflux per cell.
Joshua W. Schlegel, Samantha M. Holland, Felice D. Kelly, Eric M. Baker, Jared Stoller, William Packwood, Xin Li, Ramon F. Barajas Jr., Charles S. Springer Jr., Martin M. Pike   +9 more
wiley   +1 more source

Steroid regulation of epithelial sodium channels (ENaC) in mammary epithelial cells

The FASEB Journal, 2006
The epithelial sodium channel (ENaC) is important in lactating mammary cells for regulating the Na + content of milk, while in cancerous mammary cells ENaC may play a role in oncogenesis. The goal of this study is to determine how steroids and/or the serum‐and glucocorticoid induced kinase ...
Cary R Boyd, Aniko Naray‐Fejes‐Toth
openaire   +1 more source

Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations [PDF]

, 2009
Udgivelsesdato: 2009-Sep-30Several pathophysiological conditions, including nephrotic syndrome, are characterized by increased renal activity of the epithelial Na(+) channel (ENaC).
Jensen, Boye L, Palarasah, Yaseelan, Skjoedt, Karsten, Skøtt, Ole, Svenningsen, Per, Uhrenholt, Torben R   +5 more
core   +1 more source

Hypercapnia Effects on Lung Function

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
CO2 is a signaling molecule that disrupts alveolar fluid clearance and ion transport, impairs alveolar repair, and promotes mitochondrial and endoplasmic reticulum dysfunction. It suppresses innate immunity, host defense, and inflammation, while increasing airway contractility.
Seungseo Choi, Laura A. Dada, Jacob I. Sznajder   +2 more
wiley   +1 more source

The Alternatively Spliced Form “b” of the Epithelial Sodium Channel α Subunit (α ENaC): Any Prior Evidence of its Existence?

Clinical Medicine Insights: Cardiology, 2010
The epithelial sodium channel (ENaC) is critical in maintaining sodium balance across aldosterone-responsive epithelia. ENaC is a combined channel formed of three subunits (αβγ) with α ENaC subunit being the most critical for channel functionality.
Marlene F. Shehata
doaj  

Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis. [PDF]

, 2016
Inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease are diseases with impaired epithelial barrier function. We aimed to investigate whether mutated prostasin and thus, reduced colonic epithelial sodium channel activity ...
Auberson, M., Bonny, O., Hummler, E., Keppner, A., Malsure, S., Nobile, A.   +5 more
core   +1 more source