Results 231 to 240 of about 425,938 (288)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Oriented Multivalent Display Drives Consistent Serum Immunodominance to the Ebola Virus Glycoprotein. [PDF]

ACS Cent Sci
Zheng C, Rubio AA, Vasquez S, Pham D, Pan Z, Barnes CO, Kim PS.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A novel multi-epitope vaccine induces protective and therapeutic immunity against Helicobacter pylori. [PDF]

NPJ Vaccines
Moeini H, Mostafazadeh A, Schoenemann L, Yadegar A, Jamshidizadeh S, Nayeri K, Wedershoven V, Anderl F, Schulz C, Popper B, Malfertheiner P, Kalali B.   +11 more
europepmc   +1 more source

Designing a novel vaccine against COVID-19 based on spike SARS-Cov-2 notable mutations using immunoinformatics approaches. [PDF]

PLoS One
Rahimnahal S, Yousefizadeh S, Mohammadi Y.   +2 more
europepmc   +1 more source

De novo identification of the specificities of recurrently identified human T cell receptors. [PDF]

Sci Adv
Kasbe M, Yahsi B, Whitehead K, Oh J, Mosharraf M, Sohn K, Phan T, Lee MN.   +7 more
europepmc   +1 more source

Development of monoclonal antibodies for GoAstV-2 VP27 protein and precise mapping of linear antigenic epitopes. [PDF]

Poult Sci
Qin K, Yin L, Zhang H.
europepmc   +1 more source