Results 31 to 40 of about 607,096 (382)

An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study

Scientific Reports, 2020
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical therapy,
Zikun Yang, P. Bogdan, Shahin Nazarian
semanticscholar   +1 more source

Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis [PDF]

, 2009
Antibodies to citrulline-modifi ed proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological role in disease development is still unclear.
Aho, Andersson, Auger, Baeten, Bella, Bettina Sehnert, Brunsberg, Burkhardt, Burkhardt, Bäcklund, Caspi, Chang, Chapuy-Regaud, Collaborative Computational Project, Number 4, DeLano, Dyson, Emsley, Emsley, Emsley, Estelle Bajtner, Foulquier, Girbal-Neuhauser, Giudicelli, Grab, Guy Serre, Harald Burkhardt, Hill, Hill, Hoffmann, Hüseyin Uysal, Kabsch, Kanazawa, Kidd, Krissinel, Kuhn, Kutty S. Nandakumar, Lefranc, Marjolein M.G.M. Thunnissen, Masson-Bessière, Masson-Bessière, Michaëlsson, Molberg, Murshudov, Nair, Nandakumar, Rantapää-Dahlqvist, Read, Reparon-Schuijt, Rikard Holmdahl, Robert Bockermann, Rosloniec, Schellekens, Schellekens, Schulte, Schwab, Stanfield, Stetefeld, Tarcsa, Uysal, van der Helm-van Mil, Vander Cruyssen, von Delwig, Vossenaar, Vossenaar, Vossenaar, Vossenaar, Winn, Yousfi Monod, Zong, Åke Engström   +69 more
core   +2 more sources

Japanese Encephalitis Virus Vaccination Elicits Cross-Reactive HLA-Class I-Restricted CD8 T Cell Response Against Zika Virus Infection

Frontiers in Immunology, 2020
Japanese encephalitis virus (JEV) exposure or vaccination could elicit cross-reactive CD8 T cell immunity against heterologous flaviviruses in humans.
Marion Tarbe, Marion Tarbe, Wei Dong, Guang Hu, Guang Hu, Yongfen Xu, Yongfen Xu, Jing Sun, Solene Grayo, Solene Grayo, Xianyang Chen, Chengfeng Qin, Jincun Zhao, Li Liu, Li Liu, Xiuzhen Li, Xiuzhen Li, Qibin Leng, Qibin Leng, Qibin Leng   +19 more
doaj   +1 more source

The role of HLA-DP mismatches and donor specific HLA-DP antibodies in kidney transplantation : a case series [PDF]

, 2021
BACKGROUND: The impact of HLA-DP mismatches on renal allograft outcome is still poorly understood and is suggested to be less than that of the other HLA loci.
Abramowicz, D, Claas, FHJ, Daniëls, L, Edmonds, MP, Hellemans, R, Kramer, CSM, Naessens, M, Senev, A, Van Laecke, Steven, Vanden Driessche, M   +9 more
core   +2 more sources

An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein. [PDF]

, 2015
A monoclonal antibody (mAb) that binds to a transient intermediate may act as a catalyst for the corresponding reaction; here we show this principle can extend on a macro-molecular scale to the induction of mutant-like oligomerisation in a wild-type ...
Faull, SV, Haq, I, Irving, JA, Kotov, VR, Lomas, DA, Miranda, E, Motamedi-Shad, N, Perez, J   +7 more
core   +1 more source

Fundamentals and Methods for T- and B-Cell Epitope Prediction

Journal of Immunological Research, 2017
Adaptive immunity is mediated by T- and B-cells, which are immune cells capable of developing pathogen-specific memory that confers immunological protection.
J. L. Sánchez-Trincado, Marta Gomez-Perosanz, P. Reche   +2 more
semanticscholar   +1 more source

Current challenges for unseen-epitope TCR interaction prediction and a new perspective derived from image classification

Briefings Bioinform., 2020
The prediction of epitope recognition by T-cell receptors (TCRs) has seen many advancements in recent years, with several methods now available that can predict recognition for a specific set of epitopes.
Pieter Moris, Joey De Pauw, A. Postovskaya, Sofie Gielis, Nicolas De Neuter, Wout Bittremieux, B. Ogunjimi, K. Laukens, Pieter Meysman   +8 more
semanticscholar   +1 more source

FAIR principles and the IEDB: short-term improvements and a long-term vision of OBO-foundry mediated machine-actionable interoperability. [PDF]

, 2018
The Immune Epitope Database (IEDB), at www.iedb.org, has the mission to make published experimental data relating to the recognition of immune epitopes easily available to the scientific public.
Mungall, Christopher J, Overton, James A, Peters, Bjoern, Sette, Alessandro, Vita, Randi   +4 more
core   +2 more sources

Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools

Frontiers in Immunology, 2020
Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can ...
Anne Searls De Groot, L. Moise, Frances E Terry, A. Gutiérrez, P. Hindocha, Guilhem Richard, D. Hoft, T. Ross, A. Noe, Yoshimasa Takahashi, V. Kotraiah, S. Silk, C. Nielsen, A. Minassian, R. Ashfield, M. Ardito, S. Draper, W. Martin   +17 more
semanticscholar   +1 more source

Analisis Epitope Sel T pada SARS-Cov2 dengan Pendekatan Bioinformatika

Jurnal Nasional Teknik Elektro dan Teknologi Informasi, 2020
Pada awal tahun 2020 dunia digemparkan dengan tersebarnya wabah secara global yang menyerang pernapasan seperti wabah SARS pada tahun 2003, yaitu COVID-19. Virus penyebab wabah yang bernama SARS-Cov2 ini ternyata memiliki kemiripan ~87.5% dengan SARS-Cov.
Miftahurrahma Rosyda, Faisal Fajri Rahani   +1 more
doaj   +1 more source