Results 131 to 140 of about 395,501 (352)

Antigenicity of peptides comprising the immunosuppressive domain of the retroviral envelope glycoprotein [version 2; referees: 2 approved]

Wellcome Open Research, 2017
To achieve persistent infection of the host, viruses often subvert or suppress host immunity through mechanisms that are not entirely understood. The envelope glycoprotein of several retroviruses is thought to possess potent immunosuppressive activity ...
Bryony Jenkins, Urszula Eksmond, George Young, George Kassiotis   +3 more
doaj   +1 more source

Epitope prediction improved by multitask support vector machines [PDF]

We use various multitask kernels in order to improve MHC-I-peptide binding prediction, in particular for MHC alleles for which few training data is available. (05/02/2007), 2007
Motivation: In silico methods for the prediction of antigenic peptides binding to MHC class I molecules play an increasingly important role in the identification of T-cell epitopes. Statistical and machine learning methods, in particular, are widely used to score candidate epitopes based on their similarity with known epitopes and non epitopes.
arxiv  

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

HLA-A2-Restricted Epitopes Identified from MTA1 Could Elicit Antigen-Specific Cytotoxic T Lymphocyte Response

Journal of Immunology Research, 2018
Overexpression of metastasis-associated protein 1 (MTA1) has been observed in many human malignancies and is significantly related to tumor invasion and metastasis, therapeutic resistance to radiation and chemotherapy, making MTA1 an ideal candidate ...
Yahong Wu, Wenjie Zhai, Xiuman Zhou, Zhiwei Wang, Yan Lin, Ling Ran, Yuanming Qi, Yanfeng Gao   +7 more
doaj   +1 more source

Antigenicity of peptides comprising the immunosuppressive domain of the retroviral envelope glycoprotein [version 1; referees: 2 approved]

Wellcome Open Research, 2016
To achieve persistent infection of the host, viruses often subvert or suppress host immunity through mechanisms that are not entirely understood. The envelope glycoprotein of several retroviruses is thought to possess potent immunosuppressive activity ...
Bryony Jenkins, Urszula Eksmond, George Young, George Kassiotis   +3 more
doaj   +1 more source

Identification of MHC Class II Binders/ Non-binders using Negative Selection Algorithm [PDF]

, 2011
The identification of major histocompatibility complex (MHC) class-II restricted peptides is an important goal in human immunological research leading to peptide based vaccine design. These MHC class–II peptides are predominantly recognized by CD4+
B. N. Mishra, Bharat Bhasker, Feroz Khan, S.S. Soam   +3 more
core   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

Immunogenicity of multiple antigen peptides containing Plasmodium vivax CS epitopes in BALB/c mice

Memorias do Instituto Oswaldo Cruz, 1994
Multiple antigen peptide systems (MAPs) allow the incorporation of various epitopes in to a single synthetic peptide immunogen. We have characterized the immune response of BALB/c mice to a series of MAPs assembled with different B and T cell epitopes ...
Myriam A. Herrera, Cecilia de Plata, Jhon Mario González, Giampietro Corradin, Socrates Herrera   +4 more
doaj   +1 more source

Shifting immunodominance pattern of two cytotoxic T-lymphocyte epitopes in the F glycoprotein of the Long strain of respiratory syncytial virus.

Journal of General Virology, 2004
Human respiratory syncytial virus (RSV) is a major cause of respiratory infection in children and in the elderly. The RSV fusion (F) glycoprotein has long been recognized as a vaccine candidate as it elicits cytotoxic T-lymphocyte (CTL) and antibody ...
C. Johnstone, P. de León, Francisco Medina, J. Melero, B. García-Barreno, M. Del Val   +5 more
semanticscholar   +1 more source

Defining the expression hierarchy of latent T-cell epitopes in Epstein-Barr virus infection with TCR-like antibodies [PDF]

, 2013
Epstein-Barr virus (EBV) is a gamma herpesvirus that causes a life-long latent infection in human hosts. The latent gene products LMP1, LMP2A and EBNA1 are expressed by EBV-associated tumors and peptide epitopes derived from these can be targeted by CD8 ...
A Porgador, AD Hislop, B Engels, B Rubin, F Bihl, G Denkberg, G Held, G Stuber, J Levitskaya, JA Weidanz, JL Ryan, JW Yewdell, K Shanmugaratnam, KS Sastry, LS Young, M Yajima, MD Catalina, MH Fogg, MR Chen, N Blake, NL La Gruta, O Makler, OE Hawkins, P Parham, R Jain, RA Gottschalk, RH Edwards, SL Glaser, SP Lee, ST Cheung, WL Tamminen   +30 more
core   +1 more source