Results 21 to 30 of about 4,711 (242)

The advantages of SMRT sequencing [PDF]

, 2013
Of the current next-generation sequencing technologies, SMRT sequencing is sometimes overlooked. However, attributes such as long reads, modified base detection and high accuracy make SMRT a useful technology and an ideal approach to the complete ...
Carneiro, M. O., Roberts, R. J., Schatz, M. C.   +2 more
core   +3 more sources

Positioning Europe for the EPITRANSCRIPTOMICS challenge [PDF]

, 2018
The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built.
Almeida, Raquel, Ameres, Stefan, Ayers, Duncan, Balatsos, Nikolaos, Ballana, Ester, Bankovic, Jasna, Banovic, Bojana, Baranov, Pavel, Bousquet-Antonelli, Cecile, Bujnicki, Janusz, Cardona, Fernando, Carre, Clement, Costache, Marieta, Cowling, Victoria, Dahl, John Arne, Davalos, Alberto, David, Alexandre, Demircan, Turan, Dinnyes, Andras, Drablos, Finn, Fray, Rupert, Frye, Michaela, Fuks, Francois, Helm, Mark, Holodnuka Kholodnyuk, Irina, Jantsch, Michael, Jeronimo, Carmen, Kelly, Vincent, Klungland, Arne, Kyselovic, Jan, Lafontaine, Denis, Lamm, Ayelet, Liepins, Janis, Lyko, Frank, Macias-Gonzales, Manuel, Motorin, Yuri, Neagu, Monica, Nielsen, Henrik, O Carroll, Donal, O'Connell, Mary, Ohman, Marie, Oulas, Anastasis, Pelizzola, Mattia, Pir, Pinar, Purta, Elzbieta, Quattrone, Alessandro, Rechavi, Gideon, Roignant, Jean-Yves, Rossmanith, Walter, Schaffrath, Raffael, Schwartz, Schraga, Schäfer, Matthias, Selbert, Stefan, Timotijevic, Gordana, Ule, Jernej, Valor, Luis Miguel, Vanacova, Stepanka, Verdel, Andre, Willems, Luc, Zammit, Vanessa   +59 more
core   +13 more sources

Bioinformatics approaches for deciphering the epitranscriptome: Recent progress and emerging topics

Computational and Structural Biotechnology Journal, 2020
Post-transcriptional RNA modification occurs on all types of RNA and plays a vital role in regulating every aspect of RNA function. Thanks to the development of high-throughput sequencing technologies, transcriptome-wide profiling of RNA modifications ...
Lian Liu, Bowen Song, Jiani Ma, Yi Song, Song-Yao Zhang, Yujiao Tang, Xiangyu Wu, Zhen Wei, Kunqi Chen, Jionglong Su, Rong Rong, Zhiliang Lu, João Pedro de Magalhães, Daniel J. Rigden, Lin Zhang, Shao-Wu Zhang, Yufei Huang, Xiujuan Lei, Hui Liu, Jia Meng   +19 more
doaj   +1 more source

Deciphering the epitranscriptome: a green perspective [PDF]

, 2016
The advent of high-throughput sequencing technologies coupled with new detection methods of RNA modifications has enabled investigation of a new layer of gene regulation - the epitranscriptome.
Burgess, A., David, R., Searle, I.
core   +1 more source

Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3. [PDF]

, 2016
Epitranscriptome modifications are required for structure and function of RNA and defects in these pathways have been associated with human disease.
Blanco, Sandra, Dietmann, Sabine, Durbin, Richard, Frye, Michaela, Hoffmann, Georg F, Hussain, Shobbir, Kolb-Kokocinski, Anja, Kotzaeridou, Urania, Kremer, Laura, Lantaff, Rebecca, Mayr, Johannes A, Memari, Yasin, Minczuk, Michal, Pearce, Sarah F, Powell, Christopher A, Prokisch, Holger, Rorbach, Joanna, Sauer, Sascha, Van Haute, Lindsey   +18 more
core   +3 more sources

HIV Modifies the m6A and m5C Epitranscriptomic Landscape of the Host Cell [PDF]

, 2021
The study of RNA modifications, today known as epitranscriptomics, is of growing interest. The N6-methyladenosine (m6A) and 5-methylcytosine (m5C) RNA modifications are abundantly present on mRNA molecules, and impact RNA interactions with other proteins
Angelino, Paolo, Ciuffi, Angela, Cristinelli, Sara, Delorenzi, Mauro, Janowczyk, Andrew   +4 more
core   +1 more source

Flavin-dependent epitranscriptomic world [PDF]

Archives of Biochemistry and Biophysics, 2017
RNAs molecules fulfill key roles in the expression and regulation of the genetic information stored within the DNA chromosomes. In addition to the four canonical bases, U, C, A and G, RNAs harbor various chemically modified derivatives which are generated post-transcriptionally by specific enzymes acting directly at the polymer level.
Lombard, Murielle, Hamdane, Djemel
openaire   +3 more sources

tRNA epitranscriptomics and biased codon are linked to proteome expression in [PDF]

, 2018
Among components of the translational machinery, ribonucleoside modifications on tRNAs are emerging as critical regulators of cell physiology and stress response. Here, we demonstrate highly coordinated behavior of the repertoire of tRNA modifications of
Aniweh, Yaw, Babu, Indrakanti Ramesh, Chionh, Yok Hian, Dedon, Peter C, Gu, Chen, Nah, Qianhui, Ng, Chee Sheng, Preiser, Peter R, Sinha, Ameya   +8 more
core   +1 more source

RNA Modification Related Diseases and Sensing Methods

Applied Sciences, 2023
Epitranscriptomics is the study of RNA base modifications, including functionally relevant transcriptomic changes. Epitranscriptomics has been actively studied in recent years and has been reported to play important roles in development, homeostasis, the
Mayuka Ohkawa, Masamitsu Konno
doaj   +1 more source

Epitranscriptomics of cancer

World Journal of Clinical Oncology, 2018
The functional impact of modifications of cellular RNAs, including mRNAs, miRNAs and lncRNAs, is a field of intense study. The role of such modifications in cancer has started to be elucidated. Diverse and sometimes opposite effects of RNA modifications have been reported.
Tusup, Marina, Kundig, Thoma, Pascolo, Steve   +2 more
openaire   +2 more sources