Results 21 to 30 of about 5,392 (239)
Exploring the m<sup>5</sup>C epitranscriptome of mRNAs in breast cancer cells through genome engineering and long-read sequencing approaches. [PDF]
Funct Integr GenomicsEpitranscriptomics has emerged as a rapidly evolving field that focused on studying post-transcriptional RNA modifications and their role in spatiotemporal regulation of gene expression.
Athanasopoulou K +3 more
europepmc +2 more sources
The epitranscriptome toolbox [PDF]
Cell, 2022 In the last decade, the notion that mRNA modifications are involved in regulation of gene expression was demonstrated in thousands of studies. To date, new technologies and methods allow accurate identification, transcriptome-wide mapping, and functional characterization of a growing number of RNA modifications, providing important insights into the ...
Moshitch-Moshkovitz, Sharon +2 more
openaire +2 more sources
Environmental epitranscriptomics [PDF]
Environmental Research, 2020 Chemical modifications of RNA molecules have gained increasing attention since evidence emerged for their substantive roles in a range of biological processes, such as the stability and translation of mRNA transcripts. More than 150 modifications have been identified in different organisms to date, collectively known as the 'epitranscriptome', with 6 ...
Cayir, Akin +2 more
openaire +4 more sources
Spliceosomal snRNA Epitranscriptomics [PDF]
Frontiers in Genetics, 2021 Small nuclear RNAs (snRNAs) are critical components of the spliceosome that catalyze the splicing of pre-mRNA. snRNAs are each complexed with many proteins to form RNA-protein complexes, termed as small nuclear ribonucleoproteins (snRNPs), in the cell nucleus. snRNPs participate in pre-mRNA splicing by recognizing the critical sequence elements present
Pedro Morais, Hironori Adachi, Yi-Tao Yu
openaire +3 more sources
The hidden RNA code: implications of the RNA epitranscriptome in the context of viral infections
Frontiers in Genetics, 2023 Emerging evidence highlights the multifaceted roles of the RNA epitranscriptome during viral infections. By modulating the modification landscape of viral and host RNAs, viruses enhance their propagation and elude host surveillance mechanisms.
Diana Roberta Ribeiro +3 more
doaj +1 more source
Epitranscriptomic profile of Lactobacillus agilis and its adaptation to growth on inulin
BMC Research Notes, 2021 Objective Ribonucleic acids (RNA) are involved in many cellular functions. In general, RNA is made up by only four different ribonucleotides. The modifications of RNA (epitranscriptome) can greatly enhance the structural diversity of RNA, which in turn ...
Hongzhou Wang +6 more
doaj +1 more source
Recent advances in the plant epitranscriptome
Genome Biology, 2023 Chemical modifications of RNAs, known as the epitranscriptome, are emerging as widespread regulatory mechanisms underlying gene regulation. The field of epitranscriptomics advances recently due to improved transcriptome-wide sequencing strategies for ...
Lisha Shen +4 more
doaj +1 more source
Viral Epitranscriptomics [PDF]
Journal of Virology, 2017 ABSTRACT Although it has been known for over 40 years that eukaryotic mRNAs bear internal base modifications, it is only in the last 5 years that the importance of these modifications has begun to come into focus. The most common mRNA modification, the addition of a methyl group to the N 6 ...
Edward M, Kennedy +3 more
openaire +2 more sources
Frontiers in Genetics, 2023 Introduction: Dihydrouridine (D) is a conserved modification of tRNA among all three life domains. D modification enhances the flexibility of a single nucleotide base in the spatial structure and is disease- and evolution-associated.
Jinjin Ren +6 more
doaj +1 more source
Refined RIP-seq protocol for epitranscriptome analysis with low input materials. [PDF]
PLoS Biology, 2018 N6-Methyladenosine (m6A) accounts for approximately 0.2% to 0.6% of all adenosine in mammalian mRNA, representing the most abundant internal mRNA modifications.
Yong Zeng +11 more
doaj +1 more source