Results 31 to 40 of about 4,711 (242)
BMC Bioinformatics, 2019 Background Over one hundred different types of post-transcriptional RNA modifications have been identified in human. Researchers discovered that RNA modifications can regulate various biological processes, and RNA methylation, especially N6 ...
Xiangyu Wu +7 more
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Current epigenetic aspects the clinical kidney researcher should embrace [PDF]
, 2017 Chronic kidney disease (CKD), affecting 10-12% of the world's adult population, is associated with a considerably elevated risk of serious comorbidities, in particular, premature vascular disease and death.
Ekström, Tomas J. +5 more
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Epitranscriptomic Reprogramming Is Required to Prevent Stress and Damage from Acetaminophen [PDF]
, 2022 Epitranscriptomic marks, in the form of enzyme catalyzed RNA modifications, play important gene regulatory roles in response to environmental and physiological conditions.
Begley, Thomas John +3 more
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The Arabidopsis epitranscriptome
Current Opinion in Plant Biology, 2015 The most prevalent internal modification of plant messenger RNAs, N(6)-methyladenosine (m(6)A), was first discovered in the 1970s, then largely forgotten. However, the impact of modifications to eukaryote mRNA, collectively known as the epitranscriptome, has recently attracted renewed attention.
Fray, Rupert G., Simpson, Gordon G.
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RNA Biology, 2022 The universal dihydrouridine (D) epitranscriptomic mark results from a reduction of uridine by the Dus family of NADPH-dependent reductases and is typically found within the eponym D-loop of tRNAs.
Olivier Finet +3 more
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Epitranscriptomic regulation of insecticide resistance [PDF]
Science Advances, 2021 A cytochrome P450 that confers insecticide resistance in whitefly is regulated by an epitranscriptomic mechanism.
Xin Yang +17 more
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Genome Biology, 2018 Cells adapt to stress by altering gene expression at multiple levels. Here, we propose a new mechanism regulating stress-dependent gene expression at the level of translation, with coordinated interplay between the tRNA epitranscriptome and biased codon ...
Cheryl Chan +3 more
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m6A Regulators in Human Adipose Tissue - Depot-Specificity and Correlation With Obesity
Frontiers in Endocrinology, 2021 BackgroundN6-methyladenosine (m6A) is one of the most abundant post-transcriptional modifications on mRNA influencing mRNA metabolism. There is emerging evidence for its implication in metabolic disease.
Torunn Rønningen +12 more
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m6a RNA methylation: the implications for health and disease [PDF]
, 2014 The recent resurgence of interest in m6a has been spurred by some intriguing findings detailing the effects and dynamics of this epigenetic modification.
McGuinness, D., Mcguinness, D.H.
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Dawn of Epitranscriptomic Medicine [PDF]
Circulation: Genomic and Precision Medicine, 2018 Medicine is at the crossroads of expanding disciplines. Prompt adaptation of medicine to each rapidly advancing research field, bridging bench to bedside, is a key step toward health improvement. Cardiovascular disease still ranks first among the mortality causes in the Western world, indicating a poor adaptation rate of cardiovascular medicine, albeit
Gatsiou A, Stellos K
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