Results 71 to 80 of about 4,711 (242)
RNA editing generates cellular subsets with diverse sequence within populations [PDF]
, 2016 RNA editing is a mutational mechanism that specifically alters the nucleotide content in transcribed RNA. However, editing rates vary widely, and could result from equivalent editing amongst individual cells, or represent an average of variable editing ...
Harjanto, D. +5 more
core +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Aging through an epitranscriptomic lens
Nature Aging, 2021 The mechanistic causes of aging, the time-related decline in function and good health that leads to increased mortality, remain poorly understood. Here we propose that age-dependent alteration of the epitranscriptome, encompassing more than 150 chemically distinct post-transcriptional modifications or editing events, warrants exploration as an ...
Mary McMahon +2 more
openaire +2 more sources
British Journal of Pharmacology, EarlyView.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
Alanine tRNAs Translate Environment Into Behavior in Caenorhabditis elegans
Frontiers in Cell and Developmental Biology, 2020 Caenorhabditis elegans nematodes produce and maintain imprints of attractive chemosensory cues to which they are exposed early in life. Early odor-exposure increases adult chemo-attraction to the same cues.
Diana Andrea Fernandes De Abreu +3 more
doaj +1 more source
The how and why of lncRNA function: An innate immune perspective. [PDF]
, 2020 Next-generation sequencing has provided a more complete picture of the composition of the human transcriptome indicating that much of the "blueprint" is a vastness of poorly understood non-protein-coding transcripts.
Carpenter, Susan +2 more
core
The epitranscriptome in translation regulation: mRNA and tRNA modifications as the two sides of the same coin? [PDF]
, 2019 Translation of mRNA is a highly regulated process that is tightly coordinated with cotranslational protein maturation. Recently, mRNA modifications and tRNA modifications - the so called epitranscriptome - have added a new layer of regulation that is ...
Leidel, Sebastian A., Ranjan, Namit
core +2 more sources
IbrainNeurodegenerative disorders encompass a group of age‐related conditions characterized by the gradual decline in both the structure and functionality of the central nervous system (CNS).
Muhammad Abu Talha Safdar Hashmi +4 more
doaj +1 more source
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.ABSTRACT Background Periodontitis, a chronic inflammatory disease, represents the primary cause of tooth loss in Chinese adults. Wilms tumor 1‐associating protein (WTAP) is a key component of the N6‐methyladenosine (m6A) methyltransferase complex, and has an unclear role in periodontitis pathogenesis, particularly concerning its regulatory functions in
Menglin Xiong, Tingting Wang, Yuan Liu
wiley +1 more source
Epitranscriptome and FMRP Regulated mRNA Translation
Epigenomes, 2017 An important regulatory mechanism affecting mRNA translation involves various covalent modifications of RNA, which establish distinct epitranscriptomic signatures that actively influence various physiological processes. Dendritic translation in mammalian
Pritha Majumder +2 more
doaj +1 more source