Results 81 to 90 of about 4,711 (242)

Epitranscriptome: Review of Top 25 Most-Studied RNA Modifications [PDF]

, 2022
Viktoriia A. Arzumanian, Georgii Dolgalev, Ilya Y. Kurbatov, Olga I. Kiseleva, Ekaterina V. Poverennaya   +4 more
openalex   +1 more source

RNA N⁶-Methyladenosine Affects Copper-Induced Oxidative Stress Response in Arabidopsis thaliana

Non-Coding RNA
Recently, post-transcriptional regulation of mRNA mediated by N6-methyladenosine (m6A) has been found to have profound effects on transcriptome regulation during plant responses to various abiotic stresses.
Bishwas Sharma, Ganesan Govindan, Yongfang Li, Ramanjulu Sunkar, Brian D. Gregory   +4 more
doaj   +1 more source

Anti‐cancer effect of entacaponeon esophageal cancer cells via apoptosis induction and cell cycle modulation

Cancer Reports, 2023
Background Esophageal cancer (EC) is the sixth leading cause of cancer‐related death, despite many advances in treatment, the survival of patients still remains poor.
Fahimeh Ramedani, Seyyed Mehdi Jafari, Marie Saghaeian Jazi, Zeinab Mohammadi, Jahanbakhsh Asadi   +4 more
doaj   +1 more source

Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases

Molecular Therapy: Nucleic Acids, 2023
In recent years, N7-methylguanosine (m7G) methylation, originally considered as messenger RNA (mRNA) 5′ caps modifications, has been identified at defined internal positions within multiple types of RNAs, including transfer RNAs, ribosomal RNAs, miRNA ...
Xiaohuan Xia, Yi Wang, Jialin C. Zheng
doaj   +1 more source

Exploring the brain epitranscriptome: perspectives from the NSAS summit [PDF]

, 2023
Sungmin Lee, Bonsang Koo, Clément Carré, André Fischer, Chuan He, Ajeet Kumar, Kathy Liu, Kate D. Meyer, Guo‐li Ming, Junmin Peng, Jean‐Yves Roignant, Erik Storkebaum, Shuying Sun, Davide De Pietri Tonelli, Yinsheng Wang, Yi‐Lan Weng, Luigi Pulvirenti, Yanhong Shi, Ki‐Jun Yoon, Hongjun Song   +19 more
openalex   +1 more source

m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade [PDF]

, 2019
Melanoma is one of the most deadly and therapy-resistant cancers. Here we show that N6-methyladenosine (m6A) mRNA demethylation by fat mass and obesity-associated protein (FTO) increases melanoma growth and decreases response to anti-PD-1 blockade ...
Aplin, Andrew E., Cui, Yan-Hong, Deng, Yu, He, Chuan, He, Yu-Ying, Hwang, Seungmin, Lu, Zhike, Park, Gayoung, Shah, Palak, Wei, Jiangbo, Yang, Seungwon   +10 more
core   +1 more source

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

eLife
Tgt is the enzyme modifying the guanine (G) in tRNAs with GUN anticodon to queuosine (Q). tgt is required for optimal growth of Vibrio cholerae in the presence of sub-lethal aminoglycoside concentrations.
Louna Fruchard, Anamaria Babosan, Andre Carvalho, Manon Lang, Blaise Li, Magalie Duchateau, Quentin Giai Gianetto, Mariette Matondo, Frederic Bonhomme, Isabelle Hatin, Hugo Arbes, Céline Fabret, Enora Corler, Guillaume Sanchez, Virginie Marchand, Yuri Motorin, Olivier Namy, Valérie de Crécy-Lagard, Didier Mazel, Zeynep Baharoglu   +19 more
doaj   +1 more source

Progress and application of epitranscriptomic m6A modification in gastric cancer

RNA Biology, 2022
The relationship between epitranscriptomics and malignant tumours has become a popular research topic in recent years. N6-methyladenosine (m6A), the most common post-transcriptional modification in mammals, is involved in various physiological processes ...
Yitian Xu, Chen Huang
doaj   +1 more source

The pseudorabies virus UL13 protein kinase triggers phosphorylation of the RNA demethylase FTO, which is associated with FTO-dependent suppression of interferon-stimulated gene expression

Journal of Virology
Alpha-ketoglutarate-dependent dioxygenase, also known as fat mass and obesity-associated protein (FTO), is an RNA demethylase that mediates the demethylation of N6,2-O-dimethyladenosine (m6Am) and N6-methyladenosine (m6A). Both m6Am and m6A are prevalent
Ruth Verhamme, Robert J. J. Jansens, Jianheng Liu, Fien Van Raemdonck, Cliff Van Waesberghe, Luke Nicholson, Samie R. Jaffrey, Herman W. Favoreel   +7 more
doaj   +1 more source

N6-Methyladenosine: A Novel RNA Imprint in Human Cancer

Frontiers in Oncology, 2019
N6-Methyladenosine (m6A), a pervasive posttranscriptional modification which is reversible, has been among hotspot issues in the past several years.
Sihui Yu, Xi Li, Shiyun Liu, Rui Yang, Xiangnan Liu, Sufang Wu   +5 more
doaj   +1 more source