Results 81 to 90 of about 3,161 (116)
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Metabolism of epoxidized phosphatidylcholine by phospholipase A2 and epoxide hydrolase
Lipids, 1981AbstractThe isolation and measurement of phospholipid epoxides as major peroxidation products in biomembrane preparations prompted an investigation of enzymatic mechanisms which may be responsible for their elimination. Analysis of microsomal epoxide hydrolase and phospholipase A2 activity against a phospholipid epoxide commonly encountered in tissues ...
Robert A. Stein +2 more
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Epoxide hydrolase — polymorphism and role in toxicology
Toxicology Letters, 2000Microsomal epoxide hydrolase is a critical biotransformation enzyme that catalyzes the conversion of a broad array of xenobiotic epoxide substrates to more polar diol metabolites. The gene has been shown previously to exhibit polymorphism, including variation in the coding region leading to amino acid substitutions at positions 113 (Y/H) and 139 (H/R).
Curtis J. Omiecinski +2 more
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Toxicology Letters, 1986
The present studies identify the steric factors involved in the hydration of epoxide intermediates of some pesticides by hepatic epoxide hydrolase. Investigations were carried out regarding the formation of reactive epoxide intermediates and their different interactions with the hepatic epoxide hydrolase.
D. Cova +3 more
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The present studies identify the steric factors involved in the hydration of epoxide intermediates of some pesticides by hepatic epoxide hydrolase. Investigations were carried out regarding the formation of reactive epoxide intermediates and their different interactions with the hepatic epoxide hydrolase.
D. Cova +3 more
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The role of soluble epoxide hydrolase in preeclampsia
Medical Hypotheses, 2017Preeclampsia is a serious complication of pregnancy characterized by the development of vasospasm, hypertension and often associated with proteinuria after the 20th week of gestation. Because termination of pregnancy results in the most efficacious resolution of preeclampsia, it is a leading cause of premature delivery worldwide.
Julia M. Santos +5 more
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ChemInform Abstract: Epoxide Hydrolases as Asymmetric Catalysts
ChemInform, 1997AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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Multiple forms of epoxide hydrolase
1984Xenobiotic compounds are commonly rather nontoxic as such, but if they are lipophilic tend to accumulate in body tissues. The compounds must therefore be transformed to water-soluble metabolites in order to be excreted: in this process, reactive intermediates (such as epoxides, free radicals) can originate.
C. Timms +3 more
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Leukotriene A4 hydrolase: An epoxide hydrolase with peptidase activity
Biochemical and Biophysical Research Communications, 1990Purified leukotriene A4 hydrolase from human leukocytes is shown to exhibit peptidase activity towards the synthetic substrates alanine-4-nitroanilide and leucine-4-nitroanilide. The enzymatic activity is abolished after heat treatment (70 degrees C, 30 min).
Bert L. Vallee +6 more
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The role of epoxide hydrolases in health and disease
Archives of Toxicology, 2014Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of xenobiotic epoxides, microsomal EH
Ahmed A. El-Sherbeni, Ayman O.S. El-Kadi
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Microbial epoxide hydrolases for preparative biotransformations
Current Opinion in Biotechnology, 2001Epoxide hydrolases from microbial sources are highly versatile biocatalysts for the asymmetric hydrolysis of epoxides on a preparative scale. Besides kinetic resolution, which furnishes the corresponding vicinal diol and remaining non-hydrolysed epoxide in nonracemic form, enantioconvergent processes are possible: these are highly attractive as they ...
Kurt Faber, Andreas Steinreiber
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The regulation of cytosolic epoxide hydrolase in mice
Biochemical and Biophysical Research Communications, 1985The concentration of cytosolic epoxide hydrolase in untreated and clofibrate-treated mouse liver extracts was estimated by immunoblotting. Clofibrate treatment of mice was found to increase liver cytosolic epoxide hydrolase concentration by two fold, showing that the increase in cytosolic epoxide hydrolase in mouse liver after clofibrate treatment is ...
Sarjeet S. Gill, M.M. Pichare
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