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ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk—Signaling Beyond (ER) Stress Response [PDF]

Biomolecules, 2021
Recent studies undoubtedly show the importance of inter organellar connections to maintain cellular homeostasis. In normal physiological conditions or in the presence of cellular and environmental stress, each organelle responds alone or in coordination ...
Vaishali Kumar, Shuvadeep Maity
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Evaluation of taVNS for extreme environments: an exploration study of health benefits and stress operationality

Frontiers in Neurology, 2023
IntroductionLong-duration space missions will be a real challenge for maintaining astronauts' adaptability. Research on transcutaneous vagus nerve stimulation (taVNS) is expanding rapidly, and its modalities constitute a major research challenge.
Barbara Le Roy, Barbara Le Roy, Barbara Le Roy, Charles Martin-Krumm, Charles Martin-Krumm, Charles Martin-Krumm, Adèle Gille, Sandrine Jacob, Cécile Vigier, Sylvain Laborde, Sylvain Laborde, Damien Claverie, Stéphane Besnard, Stéphane Besnard, Marion Trousselard, Marion Trousselard, Marion Trousselard   +16 more
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Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

The EMBO Journal, 2023
Intestinal goblet cells are secretory cells specialized in the production of mucins, and as such are challenged by the need for efficient protein folding.
Eva Cloots, Phaedra Guilbert, Mathias Provost, Lisa Neidhardt, Evelien Van de Velde, Farzaneh Fayazpour, Delphine De Sutter, Savvas N Savvides, Sven Eyckerman, Sophie Janssens   +9 more
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Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

iScience, 2023
Summary: The unfolded protein response (UPR) aims to restore ER homeostasis under conditions of high protein folding load, a function primarily serving secretory cells. Additional, non-canonical UPR functions have recently been unraveled in immune cells.
Jessica Vetters, Mary van Helden, Clint De Nolf, Sofie Rennen, Eva Cloots, Evelien Van De Velde, Farzaneh Fayazpour, Justine Van Moorleghem, Manon Vanheerswynghels, Karl Vergote, Louis Boon, Eric Vivier, Bart N. Lambrecht, Sophie Janssens   +13 more
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The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

The EMBO Journal, 2023
Effector mechanisms of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) are well-characterised, but how ER proteostasis is sensed is less well understood.
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron   +7 more
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Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity

Frontiers in Immunology, 2023
In cancer, activation of the IRE1/XBP1s axis of the unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells and tumor infiltrating immune cells.
Felipe Flores-Santibañez, Felipe Flores-Santibañez, Sofie Rennen, Sofie Rennen, Dominique Fernández, Clint De Nolf, Clint De Nolf, Clint De Nolf, Clint De Nolf, Evelien Van De Velde, Evelien Van De Velde, Sandra Gaete González, Camila Fuentes, Carolina Moreno, Diego Figueroa, Álvaro Lladser, Álvaro Lladser, Takao Iwawaki, María Rosa Bono, Sophie Janssens, Sophie Janssens, Fabiola Osorio   +21 more
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Current Status of Endoplasmic Reticulum Stress in Type II Diabetes

Molecules, 2021
The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions.
Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar   +13 more
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Inhibition of ubiquitin specific peptidase 14 (USP14) promotes ER-phagy by inducing ER stress in human hepatoma HepG2 cells

Animal Cells and Systems, 2023
Autophagy plays a critical role in regulating the quality and quantity of cellular compartments; however, the mechanisms governing endoplasmic reticulum (ER) autophagy (ER-phagy) are still largely undefined.
Joon Bum Kim, Ji-Eun Bae, Na Yeon Park, Doo Sin Jo, Yong Hwan Kim, Kwiwan Jeong, Pansoo Kim, Won-Ha Lee, Eunbyul Yeom, Dong-Hyung Cho   +9 more
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Diversification and deleterious role of microbiome in gastric cancer

Cancer Reports, 2023
Gut microbiota dictates the fate of several diseases, including cancer. Most gastric cancers (GC) belong to gastric adenocarcinomas (GAC). Helicobacter pylori colonizes the gastric epithelium and is the causative agent of 75% of all stomach malignancies ...
Indranil Chattopadhyay, Rohit Gundamaraju, Ashwin Rajeev   +2 more
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Endogenous Anti-Cancer Candidates in GPCR, ER Stress, and EMT

Biomedicines, 2020
The majority of cellular responses to external stimuli are mediated by receptors such as G protein-coupled receptors (GPCRs) and systems including endoplasmic reticulum stress (ER stress).
Rohit Gundamaraju, Wenying Lu, Iman Azimi, Rajaraman Eri, Sukhwinder Singh Sohal   +4 more
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