Results 1 to 10 of about 1,295,992 (186)

ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk—Signaling Beyond (ER) Stress Response [PDF]

Biomolecules, 2021
Recent studies undoubtedly show the importance of inter organellar connections to maintain cellular homeostasis. In normal physiological conditions or in the presence of cellular and environmental stress, each organelle responds alone or in coordination ...
Vaishali Kumar, Shuvadeep Maity
doaj   +3 more sources

Targeting ER stress/ER stress response in myopathies

Redox Biology, 2019
There is more skeletal muscle tissue in the body than any other tissue and, as it is the organ of the majority of metabolic activity, muscle defect can affect the health of the entire body.
Ester Zito
doaj   +4 more sources

Evaluation of taVNS for extreme environments: an exploration study of health benefits and stress operationality

Frontiers in Neurology, 2023
IntroductionLong-duration space missions will be a real challenge for maintaining astronauts' adaptability. Research on transcutaneous vagus nerve stimulation (taVNS) is expanding rapidly, and its modalities constitute a major research challenge.
Barbara Le Roy, Barbara Le Roy, Barbara Le Roy, Charles Martin-Krumm, Charles Martin-Krumm, Charles Martin-Krumm, Adèle Gille, Sandrine Jacob, Cécile Vigier, Sylvain Laborde, Sylvain Laborde, Damien Claverie, Stéphane Besnard, Stéphane Besnard, Marion Trousselard, Marion Trousselard, Marion Trousselard   +16 more
doaj   +1 more source

Activation of goblet-cell stress sensor IRE1β is controlled by the mucin chaperone AGR2

The EMBO Journal, 2023
Intestinal goblet cells are secretory cells specialized in the production of mucins, and as such are challenged by the need for efficient protein folding.
Eva Cloots, Phaedra Guilbert, Mathias Provost, Lisa Neidhardt, Evelien Van de Velde, Farzaneh Fayazpour, Delphine De Sutter, Savvas N Savvides, Sven Eyckerman, Sophie Janssens   +9 more
doaj   +1 more source

Sugarcoating ER Stress [PDF]

Cell, 2014
The hexosamine biosynthetic pathway (HBP) generates metabolites for protein N- and O-glycosylation. Wang et al. and Denzel et al. report a hitherto unknown link between the HBP and stress in the endoplasmic reticulum. These studies establish the HBP as a critical component of the cellular machinery of protein homeostasis.
Lisa Vincenz, F.Ulrich Hartl
openaire   +3 more sources

Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection

iScience, 2023
Summary: The unfolded protein response (UPR) aims to restore ER homeostasis under conditions of high protein folding load, a function primarily serving secretory cells. Additional, non-canonical UPR functions have recently been unraveled in immune cells.
Jessica Vetters, Mary van Helden, Clint De Nolf, Sofie Rennen, Eva Cloots, Evelien Van De Velde, Farzaneh Fayazpour, Justine Van Moorleghem, Manon Vanheerswynghels, Karl Vergote, Louis Boon, Eric Vivier, Bart N. Lambrecht, Sophie Janssens   +13 more
doaj   +1 more source

The IRE1β-mediated unfolded protein response is repressed by the chaperone AGR2 in mucin producing cells

The EMBO Journal, 2023
Effector mechanisms of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) are well-characterised, but how ER proteostasis is sensed is less well understood.
Lisa Neidhardt, Eva Cloots, Natalie Friemel, Caroline A M Weiss, Heather P Harding, Stephen H McLaughlin, Sophie Janssens, David Ron   +7 more
doaj   +1 more source

Nuanced role for dendritic cell intrinsic IRE1 RNase in the regulation of antitumor adaptive immunity

Frontiers in Immunology, 2023
In cancer, activation of the IRE1/XBP1s axis of the unfolded protein response (UPR) promotes immunosuppression and tumor growth, by acting in cancer cells and tumor infiltrating immune cells.
Felipe Flores-Santibañez, Felipe Flores-Santibañez, Sofie Rennen, Sofie Rennen, Dominique Fernández, Clint De Nolf, Clint De Nolf, Clint De Nolf, Clint De Nolf, Evelien Van De Velde, Evelien Van De Velde, Sandra Gaete González, Camila Fuentes, Carolina Moreno, Diego Figueroa, Álvaro Lladser, Álvaro Lladser, Takao Iwawaki, María Rosa Bono, Sophie Janssens, Sophie Janssens, Fabiola Osorio   +21 more
doaj   +1 more source

Current Status of Endoplasmic Reticulum Stress in Type II Diabetes

Molecules, 2021
The endoplasmic reticulum (ER) plays a multifunctional role in lipid biosynthesis, calcium storage, protein folding, and processing. Thus, maintaining ER homeostasis is essential for cellular functions.
Sagir Mustapha, Mustapha Mohammed, Ahmad Khusairi Azemi, Abubakar Ibrahim Jatau, Aishatu Shehu, Lukman Mustapha, Ibrahim Muazzamu Aliyu, Rabi’u Nuhu Danraka, Abdulbasit Amin, Auwal Adam Bala, Wan Amir Nizam Wan Ahmad, Aida Hanum Ghulam Rasool, Mohd Rais Mustafa, Siti Safiah Mokhtar   +13 more
doaj   +1 more source

ER Stress and Angiogenesis [PDF]

Cell Metabolism, 2015
Proper tissue vascularization is vital for cellular function as it delivers oxygen, nutrients, hormones, and immune cells and helps to clear cellular debris and metabolic waste products. Tissue angiogenesis occurs to satisfy energy requirements and cellular sensors of metabolic imbalance coordinate vessel growth.
Binet, François, Sapieha, Przemyslaw
openaire   +2 more sources