Results 191 to 200 of about 1,305,585 (286)

UFM1 at the endoplasmic reticulum: linking ER stress, ribosome quality control, and ER-phagy. [PDF]

Essays Biochem
Komatsu M, Mao G.
europepmc   +1 more source

ER stress and β cell death — therapeutic approach to combat ER stress

Folia Pharmacologica Japonica, 2014
Takashi, Hara, Fumihiko, Urano
openaire   +3 more sources

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Integrin-specific signaling drives ER stress-dependent atherogenic endothelial activation. [PDF]

Redox Biol
Ben Dhaou C, Al-Yafeai Z, Cruz-Marquez GA, Scott ML, Pearson-Gallion B, Cockerham E, Li H, Peretik JM, Hong Y, Dhanesha N, Yurdagul A, Rom O, Bhuiyan MS, Orr AW.   +13 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

NUSAP1 Drives Endometrial Carcinoma via IP3R Phosphorylation, Calcium Dyshomeostasis, and ER-Stress-Mediated Apoptosis. [PDF]

ACS Omega
Xiao H, Wang H, Yang H, Li F, Ma L, Ma H.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Loss of BAP31 Is Detrimentally Aging Photoreceptors Through ER Stress-Mediated Retinal Degeneration. [PDF]

Cells
Gao F, Zheng Y, Wang T, Zhang M, An Y, Wang Z, Wang B.   +6 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

ER stress tolerance is regulated by copper-dependent PERK kinase activity. [PDF]

Cell Rep
Bond Newton SE, Shi X, Beratan NR, Perhacs J, Arya JK, Bond MK, Gidalevitz T, Akay-Espinoza C, Brady DC, Jordan-Sciutto KL.   +9 more
europepmc   +1 more source