Results 251 to 260 of about 1,305,585 (286)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

ER stress-induced ITPR1/ANO1 signaling drives trigeminal neuropathic pain through calcium-dependent neuronal hyperexcitability. [PDF]

J Headache Pain
Lu HJ, Shen JW, Ren NY, Hu N, Cen JK, Huang MX, Song SY, Ma LJ, Wu XB, Li X, Li MX, Wu H, Hong GS, Oh U, Gao YJ.   +14 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The Role of ER Stress and the Unfolded Protein Response in Cancer. [PDF]

Cancer Genomics Proteomics
Ghemrawi R, Kremesh S, Mousa WK, Khair M.   +3 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Alleviation of ER stress via targeted genetic engineering enhances recombinant ovalbumin secretion in <i>Saccharomyces cerevisiae</i>. [PDF]

Food Sci Biotechnol
Yoon EB, Jin KC, Lim YJ, Auh JH, Choi HG, Kim SK.   +5 more
europepmc   +1 more source

Algae-Derived C-Phycocyanin Mitigates AGE-RAGE-Induced ER Stress and Mitochondrial Apoptosis: Implications for Diabetes-Associated Neurodegeneration. [PDF]

Int J Mol Sci
Lai MC, Liu WY, Tzeng YC, Liu IM.
europepmc   +1 more source

Sappanchalcone suppresses NSCLC by oxidative stress-driven DNA damage and ER stress activation through PIEZO1 modulation. [PDF]

iScience
Wu W, Zhang R, Chen G, Chen Z, Lin Z, Chen Y, Li J, Liao W, Wang J, Wang X, Huang J, Ma L, Yu H.   +12 more
europepmc   +1 more source

Quercetin ameliorates renal injury in hyperuricemic rats via modulating ER stress pathways. [PDF]

Front Pharmacol
Liu H, Yang Q, Wang S, Wang T, Pan L, Wang X, Chi Y, Jin Z.   +7 more
europepmc   +1 more source

ER Stress-Related Biomarkers in Chronic Obstructive Pulmonary Disease: A Comprehensive Transcriptome, Mendelian Randomization, and Machine-Learning Analysis. [PDF]

Int J Chron Obstruct Pulmon Dis
Li J, Li G, Liu J, Li L, Zhou H, Fei X, Wen Y, Zhao D.   +7 more
europepmc   +1 more source