Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]
, 2011 Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core +1 more source
Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing [PDF]
, 2013 It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity.
Cakir, Isin +6 more
core +1 more source
Journal of Translational Medicine, 2023 Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate.
Tingyu Wu +4 more
doaj +1 more source
MicroRNA-494 Regulates Endoplasmic Reticulum Stress in Endothelial Cells
Frontiers in Cell and Developmental Biology, 2021 Defects in stress responses are important contributors in many chronic conditions including cancer, cardiovascular disease, diabetes, and obesity-driven pathologies like non-alcoholic steatohepatitis (NASH).
Namita Chatterjee +5 more
doaj +1 more source
Endoplasmic reticulum stress as target for treatment of hearing loss
STEMedicine, 2020 The endoplasmic reticulum (ER) plays pivotal roles in coordinating protein biosynthesis and processing. Under ER stress, when excessive misfolded or unfolded proteins are accumulated in the ER, the unfolded protein response (UPR) is activated.
Yanfei Wang, Zhigang Xu
doaj +1 more source
The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse.
PLoS Genetics, 2015 Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the ER. The cellular response to ER stress involves complex transcriptional and translational changes, important to the survival of the cell.
Clement Y Chow +4 more
doaj +1 more source
ER stress and neurodegenerative diseases [PDF]
Cell Death & Differentiation, 2006 Endoplasmic reticulum (ER) stress is caused by disturbances in the structure and function of the ER with the accumulation of misfolded proteins and alterations in the calcium homeostasis. The ER response is characterized by changes in specific proteins, causing translational attenuation, induction of ER chaperones and degradation of misfolded proteins.
D, Lindholm, H, Wootz, L, Korhonen
openaire +2 more sources
Endoplasmic reticulum stress and the protein degradation system in ophthalmic diseases [PDF]
PeerJ, 2020 Objective Endoplasmic reticulum (ER) stress is involved in the pathogenesis of various ophthalmic diseases, and ER stress-mediated degradation systems play an important role in maintaining ER homeostasis during ER stress. The purpose of this review is to
Jing-Yao Song +5 more
doaj +2 more sources
Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. [PDF]
, 2015 Organelle contact sites perform fundamental functions in cells, including lipid and ion homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in yeast, we identified new ER-mitochondria and ER-vacuole contacts specified by an
Murley, Andrew +5 more
core +2 more sources
ER stress boosts respiration [PDF]
Nature Reviews Molecular Cell Biology, 2019 Glucose deprivation induces ER stress, which enhances mitochondrial respiration by promoting the assembly of respiratory supercomplexes.
openaire +2 more sources