Results 41 to 50 of about 1,305,585 (286)

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]

, 2018
Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder, Capri, Joseph, Cohn, Whitaker, Faull, Kym F, Freeman, Michael R, Lugea, Aurelia, Pandol, Stephen J, Piplani, Honit, Sakkiah, Sugunadevi, Su, Hsin-Yuan, Waldron, Richard T, Whitelegge, Julian P, Yang, Wei, Zhou, Bo   +13 more
core   +3 more sources

Lighting Up the Stressed ER [PDF]

Cell, 2008
Balancing the capacity for protein maturation with changes in protein flux through the endoplasmic reticulum (ER) is crucial for maintaining ER homeostasis. In this issue, Merksamer et al. (2008) exploit a redox-sensitive fluorescent protein to monitor the environment inside the ER of living yeast, illuminating how this organelle responds to different ...
Kang, Sang-Wook, Hegde, Ramanujan S.
openaire   +2 more sources

Rab7a modulates ER stress and ER morphology

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2018
The Endoplasmic Reticulum (ER) is a membranous organelle with diverse structural and functional domains. Peripheral ER includes interconnected tubules, and dense tubular arrays called "ER matrices" together with bona fide flat cisternae. Transitions between these states are regulated by membrane-associated proteins and cytosolic factors.
Duarte, Mateus, Elettra Sara, Marini, Cinzia, Progida, Oddmund, Bakke   +3 more
openaire   +2 more sources

Stress management at the ER: Regulators of ER stress-induced apoptosis

Pharmacology & Therapeutics, 2012
The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are detected by ER transmembrane receptors that initiate the unfolded protein response (UPR) to restore normal ER function.
Gorman, Adrienne M., Healy, Sandra J. M., Jäger, Richard, Samali, Afshin   +3 more
openaire   +3 more sources

Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
core   +2 more sources

ER stress modulates cellular metabolism [PDF]

Biochemical Journal, 2011
Changes in metabolic processes play a critical role in the survival or death of cells subjected to various stresses. In the present study, we have investigated the effects of ER (endoplasmic reticulum) stress on cellular metabolism. A major difficulty in studying metabolic responses to ER stress is that ER stress normally leads to apoptosis and ...
Xiaoli, Wang, Colins O, Eno, Brian J, Altman, Yanglong, Zhu, Guoping, Zhao, Kristen E, Olberding, Jeffrey C, Rathmell, Chi, Li   +7 more
openaire   +2 more sources

Reciprocal regulation between ER stress and autophagy in renal tubular fibrosis and apoptosis

Cell Death and Disease, 2021
Both endoplasmic reticulum (ER) stress and autophagy have been implicated in chronic kidney injury and renal fibrosis. However, the relationship and regulatory mechanisms between ER stress and autophagy under this condition remain largely unknown.
Shaoqun Shu, Hui Wang, Jiefu Zhu, Zhiwen Liu, Danyi Yang, Wenwen Wu, Juan Cai, Anqun Chen, Chengyuan Tang, Zheng Dong   +9 more
doaj   +1 more source

The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]

, 2012
In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Kogel, Karl-Heinz, Qiang, X., Reitz, M. U., Schäfer, Patrick, Zechmann, B.   +4 more
core   +2 more sources

Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

Cell Reports
Summary: Depending on how antigens are being decoded by dendritic cells (DCs), their acquisition will induce a homeostatic or immunogenic maturation program.
Sofie Rennen, Victor Bosteels, Clint De Nolf, Sandra Maréchal, Jessica Vetters, Karo Van Lil, Greta Webb, Janne Swinnen, Evelien Van De Velde, Farzaneh Fayazpour, Ria Roelandt, Niels Vandamme, Kevin Verstaen, Stefaan C. De Smedt, Karine Breckpot, Stijn Vanhee, Philippe Gevaert, Eric Hoste, Bruno G. De Geest, Rein Verbeke, Ine Lentacker, Sophie Janssens   +21 more
doaj   +1 more source

HCV causes chronic endoplasmic reticulum stress leading to adaptation and interference with the unfolded protein response. [PDF]

PLoS ONE, 2011
BACKGROUND: The endoplasmic reticulum (ER) is the cellular site for protein folding. ER stress occurs when protein folding capacity is exceeded. This stress induces a cyto-protective signaling cascades termed the unfolded protein response (UPR) aimed at ...
Emmanuelle Merquiol, Dotan Uzi, Tobias Mueller, Daniel Goldenberg, Yaakov Nahmias, Ramnik J Xavier, Boaz Tirosh, Oren Shibolet   +7 more
doaj   +1 more source