Results 61 to 70 of about 1,305,585 (286)
Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus +6 more
wiley +1 more source
The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. [PDF]
, 2011 Excessive demands on the protein-folding capacity of the endoplasmic reticulum (ER) cause irremediable ER stress and contribute to cell loss in a number of cell degenerative diseases, including type 2 diabetes and neurodegeneration.
Austgen, Kathryn +4 more
core
ER-Phagy and ER Stress Response (ERSR) in Plants [PDF]
Frontiers in Plant Science, 2019 The endoplasmic reticulum (ER) is the starting point for protein secretion and lipid biosynthesis in eukaryotes. ER homeostasis is precisely regulated by the unfolded protein response (UPR) to alleviate stress, involving both transcriptional and translational regulators.
Yonglun Zeng +4 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga +56 more
wiley +1 more source
Endoplasmic Reticulum Stress-Related Inflammation and Cardiovascular Diseases
International Journal of Inflammation, 2011 The endoplasmic reticulum (ER) is the site of synthesis and maturation of proteins designed for secretion or for localization on the cell membrane. Various types of stress from both inside and outside cells disturb ER function, thus causing unfolded or ...
Tomomi Gotoh +2 more
doaj +1 more source
Retinoic acid-induced differentiation sensitizes myeloid progenitors cells to ER stress [PDF]
, 2017 The clonal expansion of hematopoietic myeloid precursors blocked at different stages of differentiation characterizes the acute myeloid leukemia (AML) phenotype.
Capuano, Ernestina +7 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction We developed MedSupport, a multilevel medication adherence intervention designed to address root barriers to medication adherence. This study sought to explore the feasibility and acceptability of the MedSupport intervention strategies to support a future full‐scale randomized controlled trial.
Elizabeth G. Bouchard +8 more
wiley +1 more source
Strategies targeting endoplasmic reticulum stress to improve Parkinson’s disease
Frontiers in Pharmacology, 2023 Parkinson’s disease (PD) is a common neurodegenerative disorder with motor symptoms, which is caused by the progressive death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc).
Danni Wang +6 more
doaj +1 more source
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins [PDF]
, 2013 Endoplasmic reticulum (ER) stress in intestinal secretory cells has been linked with colitis in mice and inflammatory bowel disease (IBD). Endogenous intestinal glucocorticoids are important for homeostasis and glucocorticoid drugs are efficacious in IBD.
Crane, Denis I. +10 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan +5 more
wiley +1 more source