Μελέτη της εξειδίκευσης και του μηχανισμού λειτουργίας των αμινοπεπτιδασών ERAP1, ERAP2 και IRAP [PDF]
, 2021 Οι αμινοπεπτιδάσες ERAP1, ERAP2 και IRAP αποτελούν σημαντικά συστατικά του επίκτητου ανοσοποιητικού συστήματος του ανθρώπου, συμμετέχοντας ενεργά στους μηχανισμούς αντιγονοπαρουσίασης. Λειτουργία τους είναι η παραγωγή ώριμων αντιγονικών επιτόπων, κατάλληλων για πρόσδεση σε μόρια τάξης I του MHC.
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Behçet’s disease risk association fine-mapped on the IL23R–IL12RB2 intergenic region in Koreans
Arthritis Research & Therapy, 2017 Background Behçet’s disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R–IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in a Korean genome-wide ...
Eun Ha Kang +11 more
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New aspects of spondyloarthritis pathogenesis. Part I. Genetic factors and role of HLA-B27 molecules
Rheumatology, 2014 Recent data verify understanding of spondyloarthritis (SpA) pathogenesis by showing that there is the overlap between traditionally classified subtypes in terms of genetic background (HLA-B27 alleles, variants of IL-23R, ERAP1 and ERAP2 genes), which is ...
Ewa Kontny
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The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases
Frontiers in Immunology, 2017 Antigenic peptides presented by the major histocompatibility complex class I (MHC-I) molecules for recognition by cytotoxic T-lymphocytes are processed by members of the oxytocinase sub-family of M1 aminopeptidases ERAP1, ERAP2, and IRAP.
Athanasios Papakyriakou +2 more
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HeliyonBackground: Malignant tumours, particularly non-small cell lung cancer (NSCLC), pose a significant threat to human health due to their prevalence and lethality.
Shaodi Wen +13 more
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Targeting inflammatory pathways in axial spondyloarthritis. [PDF]
, 2019 The triggers and pathogenesis of axial spondyloarthritis (axSpA) are not yet completely understood. However, therapeutic agents targeting tumor necrosis factor-α and interleukin-17 inflammatory pathways have proven successful in suppressing many of the ...
Furst, Daniel E, Louie, James S
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The Role of Aminopeptidase ERAP1 in Human Pathology—A Review
Current Issues in Molecular BiologyAminopeptidases are a group of enzymatic proteins crucial for protein digestion, catalyzing the cleavage of amino acids at the N-terminus of peptides. Among them are ERAP1 (coding for endoplasmic reticulum aminopeptidase 1), ERAP2 (coding for endoplasmic
Laura Țiburcă +5 more
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THE UNCHARTED ROLE OF ERAP2 IN AGING: A BIOINFORMATICS PERSPECTIVE
AbstractBackgroundAging is associated with significant changes in the immune system, leading to increased susceptibility to infections, reduced vaccine efficacy, and a higher risk of autoimmune diseases. However, the molecular mechanisms driving these immunological alterations remain incompletely understood.
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The Impact of ERAP1 and ERAP2 Haplotype Combinations on Susceptibility and Severity of Birdshot Chorioretinitis. [PDF]
Invest Ophthalmol Vis SciLoeliger J +10 more
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Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease. [PDF]
Mamm GenomeWin LK +6 more
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