Evaluating the causal effect of circulating proteome on the risk of Juvenile idiopathic arthritis: an omics pipeline study [PDF]
Pediatric Rheumatology Online JournalBackground Genome-wide association studies (GWAS) have pinpointed a multitude of risk loci associated with Juvenile Idiopathic Arthritis (JIA), but it is challenging to decipher novel plasma proteins.
Xinglin Wu +6 more
doaj +2 more sources
Genetic association of ERAP1 and ERAP2 with eclampsia and preeclampsia in northeastern Brazilian women [PDF]
Scientific Reports, 2021 The clinical spectrum of hypertensive disorders of pregnancy (HDP) is determined by the interplay between environmental and genetic factors, most of which remains unknown.
Leonardo Capistrano Ferreira +6 more
doaj +3 more sources
The Differential Expression of ERAP1/ERAP2 and Immune Cell Activation in Pre-eclampsia [PDF]
Frontiers in Immunology, 2020 Pre-eclampsia (PE) is a disorder of pregnancy, often leading to serious and fatal complications. Endoplasmic reticulum aminopeptidase 1 and 2 (ERAP1/ERAP2) are present in the placenta.
Kimberly Seamon +7 more
doaj +3 more sources
The role of endoplasmic reticulum aminopeptidase ERAP2 pathogenic mutation rs1363907 in amoxicillin clavulanate-induced liver injury: a special case report [PDF]
Frontiers in PharmacologyIdiosyncratic hepatotoxicity is a type of drug-induced liver injury (DILI) that is unpredictable and clinically severe, and amoxicillin clavulanate (AC) is the most implicated drug in DILI worldwide. The clinical manifestations of amoxicillin clavulanate-
Yan Zhan +18 more
doaj +2 more sources
An integrated multi-omics analysis identifies protein biomarkers and potential drug targets for psoriatic arthritis [PDF]
Communications BiologyPsoriatic arthritis (PsA) is a complex, chronic immune-mediated inflammatory arthropathy that currently lacks definitive biomarkers and treatment targets. Identifying biomarkers and treatment targets is urgently needed for effectively managing PsA. Here,
Yi-Xin Cai +6 more
doaj +2 more sources
Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization [PDF]
BMC Pulmonary MedicineBackground Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Current options such as glucocorticoids and bronchodilators improve symptoms but carry risks, including infection and immunosuppression. To guide safer,
Qinyao Jia +6 more
doaj +2 more sources
Polymorphisms in ERAP1 and ERAP2 Genes Are Associated With Tuberculosis in the Han Chinese [PDF]
Frontiers in Genetics, 2020 Single nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase (ERAP1 and ERAP2) genes are associated with the pathogenesis of bacterial and viral infections.
Shuqiong Zhang +12 more
doaj +3 more sources
Integrative genomic analysis identifies novel causal genes of Hodgkin’s and non-Hodgkin’s lymphoma [PDF]
Discover OncologyBackground The genetic mechanisms underlying non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) remain understudied. While numerous genes associated with these lymphoid tumors have been identified, little research has focused on the genetic networks ...
Patrick Shi, Ancha Baranova, Hongbao Cao
doaj +2 more sources
Endoplasmic reticulum aminopeptidase 2 regulates CD4+ T cells pyroptosis in rheumatoid arthritis [PDF]
Arthritis Research & TherapyObjective Rheumatoid arthritis (RA) is a chronic, progressive autoimmune disease with a complex pathogenesis that has not yet been fully elucidated, and T-cell pyroptosis is an important pathogenetic factor in RA. This study aimed to investigate the role
Jianhua Zhang +9 more
doaj +2 more sources
ERAP Inhibitors in Autoimmunity and Immuno-Oncology: Medicinal Chemistry Insights [PDF]
J Med ChemEndoplasmic reticulum aminopeptidases ERAP1 and 2 are intracellular aminopeptidases that trim antigenic precursors and generate antigens presented by major histocompatibility complex class I (MHC-I) molecules.
Afantitis, Antreas +9 more
core +3 more sources