Results 31 to 40 of about 2,825 (159)

ERAP1 and ERAP2 Enzymes: A Protective Shield for RAS against COVID-19? [PDF]

International Journal of Molecular Sciences, 2021
Patients with coronavirus disease 2019 (COVID-19) have a wide variety of clinical outcomes ranging from asymptomatic to severe respiratory syndrome that can progress to life-threatening lung lesions. The identification of prognostic factors can help to improve the risk stratification of patients by promptly defining for each the most effective therapy ...
Silvia D’Amico, Patrizia Tempora, Valeria Lucarini, Ombretta Melaiu, Stefania Gaspari, Mattia Algeri, Doriana Fruci   +6 more
openaire   +5 more sources

Variation in ERAP2 has opposing effects on severe respiratory infection and autoimmune disease [PDF]

The American Journal of Human Genetics, 2023
IntroductionERAP2is an aminopeptidase involved in immunological antigen presentation. Genotype data in human samples from before and after the Black Death, an epidemic due toYersinia pestis, have marked changes in population allele frequency of the common single nucleotide polymorphism (SNP) rs2549794.
Baillie, J Kenneth, Davey Smith, George, Ghazal, Peter, Hamilton, Fergus, Mentzer, Alexander J, Parks, Tom, Timpson, Nicholas J.   +6 more
core   +7 more sources

ERAP1–ERAP2 Dimerization Increases Peptide-Trimming Efficiency [PDF]

The Journal of Immunology, 2014
Abstract The endoplasmic reticulum aminopeptidases (ERAP)1 and ERAP2 play a critical role in the production of final epitopes presented by MHC class I molecules. Formation of heterodimers by ERAP1 and ERAP2 has been proposed to facilitate trimming of epitope precursor peptides, but the effects of dimerization on ERAP function remain ...
Irini, Evnouchidou, Mirjana, Weimershaus, Loredana, Saveanu, Peter, van Endert   +3 more
openaire   +2 more sources

ERAP2 supports TCR recognition of three immunotherapy targeted tumor epitopes

Molecular Immunology, 2023
The therapy of cancer by adoptive T cell transfer (ACT) requires T cell receptors (TCRs) with optimal affinity for HLA class I-bound peptides (pHLA-I). But not every patient responds to ACT. Therefore, it is critical to understand the individual factors influencing the recognition of HLA class I-bound peptides (pHLA-I) by TCRs.
Karin, Schmidt, Matthias, Leisegang, Peter-Michael, Kloetzel   +2 more
openaire   +2 more sources

The emerging multifunctional roles of ERAP1, ERAP2 and IRAP between antigen processing and renin-angiotensin system modulation

Frontiers in Immunology, 2022
The Endoplasmic Reticulum Aminopeptidase 1 and 2 (ERAP1 and ERAP2) and Insulin Regulated Aminopeptidase (IRAP) are three M1 zinc metalloproteases whose role in antigen processing is the refining of peptidome either in the Endoplasmic reticulum (ERAP1 and
Benedetta Mattorre, Valentina Tedeschi, Giorgia Paldino, Maria Teresa Fiorillo, Fabiana Paladini, Rosa Sorrentino   +5 more
doaj   +1 more source

To Be or Not to Be: The Case of Endoplasmic Reticulum Aminopeptidase 2

Frontiers in Immunology, 2022
To be, or not to be, that is the question. (William Shakespeare, Hamlet)Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2, respectively) play a role in trimming peptides that are too long to be bound and presented by class I HLA (HLA-I ...
Piotr Kuśnierczyk
doaj   +1 more source

ERAP, KIR, and HLA-C Profile in Recurrent Implantation Failure

Frontiers in Immunology, 2021
The mother’s uterine immune system is dominated by uterine natural killer (NK) cells during the first trimester of pregnancy. These cells express killer cell immunoglobulin-like receptors (KIRs) of inhibitory or activating function. Invading extravillous
Karolina Piekarska, Paweł Radwan, Agnieszka Tarnowska, Andrzej Wiśniewski, Michał Radwan, Michał Radwan, Jacek R. Wilczyński, Andrzej Malinowski, Andrzej Malinowski, Izabela Nowak   +9 more
doaj   +1 more source

A Short ERAP2 That Binds IRAP Is Expressed in Macrophages Independently of Gene Variation [PDF]

International Journal of Molecular Sciences, 2022
The M1 zinc metalloproteases ERAP1, ERAP2, and IRAP play a role in HLA-I antigen presentation by refining the peptidome either in the ER (ERAP1 and ERAP2) or in the endosomes (IRAP). They have also been entrusted with other, although less defined, functions such as the regulation of the angiotensin system and blood pressure.
Benedetta Mattorre, Silvana Caristi, Simona Donato, Emilia Volpe, Marika Faiella, Alessandro Paiardini, Rosa Sorrentino, Fabiana Paladini   +7 more
openaire   +2 more sources

Ankylosing Spondylitis: a trade Off of HLA-B27, ERAP, and pathogen interconnections? Focus on Sardinia [PDF]

, 2019
The frequency of HLA-B27 in patients with Ankylosing Spondylitis (AS) is over 85%. There are more than 170 recognized HLA-B27 alleles but the majority of them is not sufficiently represented for genetic association studies.
Cauli, A, Fiorillo, Mt, Mathieu, A, Paladini, F, Sorrentino, R., Tedeschi, V   +5 more
core   +2 more sources

Phenylsulfamoyl Benzoic Acid Inhibitor of ERAP2 with a Novel Mode of Inhibition

ACS Chemical Biology, 2022
ERAP1 and ERAP2 are endoplasmic reticulum zinc-binding aminopeptidases that play crucial roles in processing peptides for loading onto class I major histocompatibility complex proteins. These enzymes are therapeutic targets in cancer and autoimmune disorders.
Richa Arya, Zachary Maben, Digamber Rane, Akbar Ali, Lawrence J. Stern   +4 more
openaire   +2 more sources