Results 61 to 70 of about 2,825 (159)

ERAP2 as a potential biomarker for predicting gemcitabine response in patients with pancreatic cancer

Aging, 2022
Abstract Background Pancreatic cancer is one of the most malignant tumors, with rapid metastasis, high mortality rate, and difficult early screening. Currently, gemcitabine is a first-line drug for pancreatic cancer patients, but its clinical effect is limited due to drug resistance.
Yu, Pian, Luo, Shifu, Cai, Jiaxin, Li, Jie, Peng, Cong   +4 more
openaire   +2 more sources

Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis

Frontiers in Cell and Developmental Biology, 2022
The clinical management of patients with COVID-19 and cancer is a Gordian knot that has been discussed widely but has not reached a consensus. We introduced two-sample Mendelian randomization to investigate the causal association between a genetic ...
Yiyin Zhang, Qijiang Mao, Yirun Li, Jiaxi Cheng, Qiming Xia, Guoqiao Chen, Peng Chen, Shengxi Jin, Duguang Li, Cheng Zhong, Jing Yang, Xiaoxiao Fan, Xiaoxiao Fan, Yuelong Liang, Hui Lin, Hui Lin   +15 more
doaj   +1 more source

TAPBPR: a new player in the MHC class I presentation pathway. [PDF]

, 2015
In order to provide specificity for T cell responses against pathogens and tumours, major histocompatibility complex (MHC) class I molecules present high-affinity peptides at the cell surface to T cells.
Abe, Apcher, Apcher, Bakke, Basha, Bevan, Boyle, Boyle, Brewerton, Brocke, Burton, Chen, Chen, Cho, D'Alessio, Dalchau, Degen, Del Val, Denzin, Denzin, Deverson, Dick, Dong, Du Pasquier, Eisenlohr, Ellgaard, Elliott, Evans, Evnouchidou, Frickel, Gao, Garbi, Garstka, Garstka, Goulder, Grandea, Grandea, Greenwood, Hall, Ham, Hateren, Hermann, Howarth, Joffre, Kanaseki, Kienast, Kleijmeer, Korfali, Kozik, Kunte, Ladasky, Lampen, Landis, Leach, Lehner, Lewis, Lotteau, Marguet, Maric, Neisig, Oliveira, Ortmann, Paquet, Park, Park, Park, Paulsson, Peaper, Peaper, Peh, Petersen, Porter, Purcell, Reeves, Riberdy, Rizvi, Roche, Roche, Romagnoli, Rufer, Sadasivan, Salter, Saric, Saunders, Schlosstein, Serwold, Spies, Spies, Spies, Spiliotis, Starck, Sugita, Suh, Teng, Trowsdale, Turnquist, Turnquist, Vigna, Wearsch, Wearsch, Wei, Williams, Yewdell, York, Zernich, Zhang, Zhang   +106 more
core   +2 more sources

Computational Insights on the Impact of Allotypic Variation and Dimerization on Erap1 and Erap2 Structures Running Title: Structural Analysis of Erap1 and Erap2 Allotype Dimers

, 2023
Abstract Ankylosing Spondylitis is an autoimmune disease leading to inflammation in the joints and ligaments of the spine. ERAP1 is a major risk factor for AS and ERAP1 mutations may result in structural changes that alter the trimming efficiency, thereby altering the immune response. The underlying structural mechanisms of AS pathogenesis have
Yunus Emre Dilek, İrem Kara, Sena Kıvrak, Şeyma Çolakoğlu Özkaya, Can Erzik, Kerem Yiğit Abacar, Mehmet Pamir Atagündüz, Gunseli Bayram Akcapinar   +7 more
openaire   +1 more source

Studies of stem cell and adhesion proteins in breast cancer [PDF]

, 2014
Breast cancer is the commonest cancer and second leading cause of cancer death in women. It has been shown that breast cancer tumorigenic/stem cell like cells are CD24-/low CD44+EpCAM+.
Gadalla, Salah-Eldin
core   +1 more source

Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis [PDF]

Human Molecular Genetics, 2018
AbstractBirdshot Uveitis (Birdshot) is a rare eye condition that affects HLA-A29-positive individuals and could be considered a prototypic member of the recently proposed “MHC-I-opathy” family. Genetic studies have pinpointed the ERAP1 and ERAP2 genes as shared associations across MHC-I-opathies, which suggests ERAP dysfunction may be a root cause for ...
Kuiper, Jonas J.W., van Setten, Jessica, Devall, Matthew, Cretu-Stancu, Mircea, Hiddingh, Sanne, Ophoff, Roel A., Missotten, Tom O.A.R., van Velthoven, Mirjam, Den Hollander, Anneke I, Hoyng, Carel B, James, Edward, Reeves, Emma, Cordero-Coma, Miguel, Fonollosa, Alejandro, Adán, Alfredo, Martín, Javier, Koeleman, Bobby P.C., de Boer, Joke H., Pulit, Sara L., Márquez, Ana, Radstake, Timothy R. D. J.   +20 more
openaire   +8 more sources

The potential impact of the fetal genotype on maternal blood pressure during pregnancy. [PDF]

, 2014
The heritability of pregnancy-induced hypertension (encompassing both gestational hypertension and preeclampsia) is around 0.47, suggesting that there is a genetic component to its development.
Beardsall, Kathryn, Dunger, David B, Petry, Clive J   +2 more
core   +1 more source

The value of cuproptosis-related differential genes in guiding prognosis and immune status in patients with skin cutaneous melanoma

Frontiers in Pharmacology, 2023
Background: Skin cutaneous melanoma (SKCM) is one of the most common cutaneous malignancies, which incidence is increasing. Cuproptosis is a new type of programming cell death recently reported, which may affect the progression of SKCM.Method: The mRNA ...
Yuming Sun, Shaorong Lei, Xiangyue Luo, Chufeng Jiang, Zhexuan Li   +4 more
doaj   +1 more source

Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design [PDF]

, 2014
The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells.
Boucau, Julie, Dinter, Jens, Kourjian, Georgio, Le Gall, Sylvie, Rucevic, Marijana   +4 more
core   +2 more sources

Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease [PDF]

, 2015
BACKGROUND: Machado-Joseph disease (or spinocerebellar ataxia type 3) is a late-onset polyglutamine neurodegenerative disorder caused by a mutation in the ATXN3 gene, which encodes for the ubiquitously expressed protein ataxin-3.
Bettencourt, Bruno, Bettencourt, Conceição, Bruges-Armas, Jácome, Coppola, Giovanni, Gao, Fuying, Geschwind, Daniel, Kay, Teresa, Kazachkova, Nadiya, Lima, Manuela, Maciel, P., Ramos, Amanda, Raposo, Mafalda, Rodrigues, Ana João, Vasconcelos, João   +13 more
core   +2 more sources