Results 71 to 80 of about 2,825 (159)

From expression pattern to genetic association in asthma and asthma-related phenotypes [PDF]

, 2012
Background : Asthma is a complex disease characterized by hyperresponsiveness, obstruction and inflammation of the airways. To date, several studies using different approaches as candidate genes approach, genome wide association studies, linkage ...
Bordeleau, Martine, Laprise, Catherine, Laviolette, Michel, Vaillancourt, Vanessa T   +3 more
core   +2 more sources

Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women

International Journal of Genomics, 2018
Recent studies have demonstrated the importance of endoplasmic reticulum aminopeptidase (ERAP) in blood pressure (BP) homeostasis. To date, no large prospective, genetic–epidemiological data are available on genetic variation within ERAP and hypertension
Robert Y. L. Zee, Alicia Rivera, Yaritza Inostroza, Paul M. Ridker, Daniel I. Chasman, Jose R. Romero   +5 more
doaj   +1 more source

Maternal Pre-Pregnancy Obesity Is Associated with Altered Placental Transcriptome [PDF]

, 2018
Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence that maternal obesity has a negative influence on placental development and function, thereby adversely influencing offspring programming and health outcomes.
Altmäe, Signe, Bartel, S., Beckers, J., Brandi, P., Campoy Folgoso, Cristina, Demmelmair, H., Esteban, F. J., Irmler, M., Koletzko, B. (Berthold), Krauss-Etschmann, S., López Sabater, María del Carmen, Segura, Mª Teresa   +11 more
core   +1 more source

Contribution of Antigen-Processing Machinery Genetic Polymorphisms to Atopic Dermatitis

Life, 2021
Atopic dermatitis (AD) is a chronic and recurrent inflammatory dermatosis. We recently described an association of the C allele of the single nucleotide polymorphism (SNP) rs26618 in the ERAP1 gene and a synergism of ERAP1 and ERAP2 effects on AD risk ...
Wanda Niepiekło-Miniewska, Łukasz Matusiak, Joanna Narbutt, Alekandra Lesiak, Piotr Kuna, Andrzej Wiśniewski, Piotr Kuśnierczyk   +6 more
doaj   +1 more source

A role for naturally occurring alleles of Endoplasmic Reticulum Aminopeptidases in tumor immunity and cancer predisposition

Frontiers in Oncology, 2014
Endoplasmic Reticulum aminopeptidase 1 and 2 (ERAP1 and ERAP2) are key components on the pathway that generates antigenic epitopes for presentation to cytotoxic T-lymphocytes (CTLs).
Efstratios eStratikos, Athanasios eStamogiannos, Efthalia eZervoudi, Doriana eFruci   +3 more
doaj   +1 more source

Apprêtement des antigènes présentés par les molécules de classe I du CMH [PDF]

, 2006
Les défenses immunitaires de l’organisme vis-à-vis des agents pathogènes et des cellules malignes reposent en grande partie sur la surveillance par les lymphocytes T cytotoxiques.
Endert, Peter van
core  

Correction to: The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response [PDF]

Journal of Translational Medicine
Siri Sæterstad, Ann Elisabeth Østvik, Marianne Doré Hansen, Torunn Bruland, Atle van Beelen Granlund   +4 more
doaj   +2 more sources

The global effect of follicle-stimulating hormone and tumour necrosis factor α on gene expression in cultured bovine ovarian granulosa cells [PDF]

, 2014
Background Oocytes mature in ovarian follicles surrounded by granulosa cells. During follicle growth, granulosa cells replicate and secrete hormones, particularly steroids close to ovulation.
Glister, Claire, Hatzirodos, Nicholas, Hummitzsch, Katja, Knight, Philip G, Rodgers, Raymond J   +4 more
core   +2 more sources

DISSECTING ERAP2 ROLE IN HIV-1 INFECTION

, 2019
Background: Immune response during HIV-1 infection and replication is quite complex because many viral and host factors, beyond individual variables, are involved at different levels. Many efforts have been made to evaluate the influence of these factors on HIV-1 infection and disease progression mainly focusing on the identification of genetic ...
openaire   +1 more source

The interplay between HLA-B27 and ERAP1/ERAP2 aminopeptidases: from anti-viral protection to spondyloarthritis [PDF]

Clinical and Experimental Immunology, 2017
SummaryThe human leukocyte antigen class I gene HLA-B27 is the strongest risk factor for ankylosing spondylitis (AS), a chronic inflammatory arthritic disorder. More recently, the Endoplasmic Reticulum Aminopeptidase (ERAP) 1 and 2 genes have been identified by genome wide association studies (GWAS) as additional susceptibility factors.
VITULANO, CAROLINA, TEDESCHI, VALENTINA, PALADINI, Fabiana, SORRENTINO, Rosa, FIORILLO, Maria Teresa   +4 more
openaire   +2 more sources