Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency [PDF]
ACS Medicinal Chemistry Letters, 2017 Endoplasmic reticulum aminopeptidase 2 assists with the generation of antigenic peptides for presentation onto Major Histocompatibility Class I molecules in humans. Recent evidence has suggested that the activity of ERAP2 may contribute to the generation of autoimmunity, thus making ERAP2 a possible pharmacological target for the regulation of adaptive
Anastasia Mpakali +10 more
openaire +3 more sources
A Gene-Based Association Method for Mapping Traits Using Reference Transcriptome Data [PDF]
, 2015 Genome-wide association studies (GWAS) have identified thousands of variants robustly associated with complex traits. However, the biological mechanisms underlying these associations are, in general, not well understood.
Aquino-Michaels, Keston +11 more
core +3 more sources
RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis—Novel Targets for Therapy?
Frontiers in Immunology, 2019 Susceptibility to ankylosing spondylitis (AS) is polygenic with more than 100 genes identified to date. These include HLA-B27 and the aminopeptidases (ERAP1, ERAP2, and LNPEPS), which are involved in antigen processing and presentation to T-cells, and ...
Matteo Vecellio +11 more
doaj +1 more source
Role of endoplasmic reticulum aminopeptidases in health and disease: from infection to cancer [PDF]
, 2012 Endoplasmic reticulum (ER) aminopeptidases ERAP1 and ERAP2 (ERAPs) are essential for the maturation of a wide spectrum of proteins involved in various biological processes. In the ER, these enzymes work in concert to trim peptides for presentation on MHC
Locatelli, Franco (ORCID:0000-0002-7976-3654)
core +1 more source
Charity auctions for the happy few [PDF]
, 2008 Recent literature has shown that all-pay auctions raise more money for charity than winner-pay auctions. We demonstrate that the first and second-price winner-pay auctions generate higher revenue than first-price all-pay auctions when bidders are ...
Bos, Olivier
core
Association Study of Common Genetic Variants and HIV- 1 Acquisition in 6,300 Infected Cases and 7,200 Controls [PDF]
, 2013 Multiple genome-wide association studies (GWAS) have been performed in HIV-1 infected individuals, identifying common genetic influences on viral control and disease course. Similarly, common genetic correlates of acquisition of HIV-1 after exposure have
Bakker, De +46 more
core +7 more sources
Identification of a myometrial molecular profile for dystocic labor
BMC Pregnancy and Childbirth, 2011 Background The most common indication for cesarean section (CS) in nulliparous women is dystocia secondary to ineffective myometrial contractility. The aim of this study was to identify a molecular profile in myometrium associated with dystocic labor ...
O'Connor Darran P +5 more
doaj +1 more source
Transcriptome profiling of IL-17A preactivated mesenchymal stem cells: a comparative study to unmodified and IFN-gamma modified mesenchymal stem cells [PDF]
, 2017 Published 15 February 2017Human mesenchymal stem cells pretreatment with IL-17A (MSC-17) potently enhances T cell immunosuppression but not their immunogenicity, in addition to avidly promoting the induction of suppressive regulatory T cells.
Coates, P.T. +4 more
core +4 more sources
Charity Auctions for the Happy Few [PDF]
Recent literature has shown that all-pay auctions raise more money for charity than winner-pay auctions. We demonstrate that the first-price and second-price winner-pay auctions outperform the first-price and second-price all-pay auction when bidders are
Olivier Bos
core
Genetic adaptation of the antibacterial human innate immunity network [PDF]
, 2011 [Background] Pathogens have represented an important selective force during the adaptation of modern human populations to changing social and other environmental conditions.
Aura Muntasell +9 more
core +3 more sources