Results 91 to 100 of about 2,350,327 (205)

A Retrospective Study on the Clinicopathological Characteristics and Prognostic Analysis of Gynecologic Neuroendocrine Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Gynecologic neuroendocrine carcinomas (NECs) are rare, highly aggressive malignancies with early metastatic potential and limited evidence to guide optimal management across different primary sites. Aims To characterize the clinicopathological features, treatment patterns, survival outcomes, and prognostic factors of gynecologic ...
Yedan Ren, Sen Li, Simin Xiang, Junfen Xu   +3 more
wiley   +1 more source

Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma. [PDF]

Front Oncol, 2023
Breitenecker K, Hedrich V, Pupp F, Chen D, Řezníčková E, Ortmayr G, Huber H, Weber G, Balcar L, Pinter M, Mikulits W.   +10 more
europepmc   +1 more source

Feedback regulation between histone H3 lysine 18 lactylation and TROP2‐mediated glycolysis drives metastatic progression of colorectal cancer

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
TROP2 is upregulated in CRC metastasis and promotes lactate overproduction via YBX1‐HIF‐1α signalling. TROP2 signalling induces H3K18la at metastasis genes promoters in CRC and promotes their expression. AccLactate sustains TROP2 expression in CRC cells via H3K18la Acriflavine suppresses TROP2‐driven CRLM by targeting the H3K18la/TROP2 feedback loop ...
Weifeng Wang, Yuxiang Deng, Weihao Li, Ruowei Wang, Chi Zhou, Yanbo Xu, Jiahua He, Le' en Liao, Jin Lan, Long Yu, Da Kang, Weili Zhang, Qingjian Ou, Zhizhong Pan, Yujing Fang, Peirong Ding, Junzhong Lin, Jianhong Peng   +17 more
wiley   +1 more source

The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease

Biomarker Insights, 2015
Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function.
Cassady E. Rupert, Kareen L.K. Coulombe
doaj   +1 more source

ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author. [PDF]

J Mammary Gland Biol Neoplasia, 2023
Morato A, Accornero P, Hovey RC.
europepmc   +1 more source

ON-III inhibits erbB-2 tyrosine kinase receptor signal pathway and triggers apoptosis through induction of Bim in breast cancer cells [PDF]

, 2009
Dan-Dan Li, Xiao-Qi Wu, Jun Tang, Xiao-Yi Wei, Xiao‐Feng Zhu   +4 more
openalex   +1 more source

The efficacy of Herceptin therapies is influenced by the expression of other erbB receptors, their ligands and the activation of downstream signalling proteins

British Journal of Cancer, 2004
ErbB2 and EGFR are attractive oncology therapeutic targets as their overexpression in tumors predicts a poorer clinical outcome in a variety of epithelial malignancies.
BL Smith, D. Chin, W. Maltzman, K. Crosby, G. Hortobagyi, SS Bacus   +5 more
semanticscholar   +1 more source

Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

Food Frontiers, Volume 7, Issue 1, January 2026.
Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli, Anna Maria Posadino, Roberta Giordo, Antonio Barberis, Ylenia Spissu, Redouane Lemoui, William N. Setzer, Javad Sharifi‐Rad, Gianfranco Pintus   +8 more
wiley   +1 more source

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Molecular Systems Biology, 2009
The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis.
William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger, Peter K Sorger   +6 more
doaj   +1 more source

Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization. [PDF]

Mol Biol Res Commun, 2023
Mashayekh-Poul R, Azimzadeh-Irani M, Masoomi-Nomandan SZ.   +2 more
europepmc   +1 more source