Results 11 to 20 of about 511,445 (325)

Aufschwung des Klausenburger Musiklebens in der ersten Hälfte des 19. Jahrhunderts

Studia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica, 2019
Cluj's music culture, emerging during the first half of the 19ᵗʰ century. The article focuses on the developing music culture of Cluj, one of the important cities in Transylvania, the easternmost province of Austria-Hungary.
Erich TÜRK
doaj   +1 more source

SLAMF8 promotes the proliferation and migration of synovial fibroblasts by regulating the ERK/MMPs signalling pathway

Autoimmunity, 2022
Rheumatoid arthritis is troublesome to treat effectively and often requires concomitant long-term treatment. Meanwhile, synovial fibroblasts could induce inflammation response and lead to joint erosion, finally causing progressive joint destruction ...
Jun Liu, Ying Huang, Jiashun Zeng, Changming Chen, Peiting Li, Qiaoyi Ning, Xianyue Guan, Long Li   +7 more
doaj   +1 more source

Sorafenib combined with ophiopogonin D' inhibits ERK and AKT pathways to promote apoptosis in androgen-independent prostate cancer PC3 cells

Di-san junyi daxue xuebao, 2021
Objective To investigate the anti-tumor effect of sorafenib (Sor) combined with Ophiopogonin D'(OPD') on androgen-independent prostate cancer (PC3) cells and its mechanism.
ZHANG Yaowen, LU Zongliang, LI Long, XU Hongxia   +3 more
doaj   +1 more source

IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation [PDF]

The EMBO Journal, 2002
IEX-1 is an early response and NF-kappaB target gene implicated in the regulation of cellular viability. We show here that IEX-1 is a substrate for ERKs and that IEX-1 and ERK regulate each other's activities. IEX-1 was isolated by phosphorylation screening with active ERK2 and found subsequently phosphorylated in vivo upon ERK activation.
Josefina, Garcia, Yunbin, Ye, Valérie, Arranz, Claire, Letourneux, Guillaume, Pezeron, Françoise, Porteu   +5 more
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Pulsatile Hormonal Signaling to Extracellular Signal-Regulated Kinase: Exploring System Sensitivity to Gonadotropin-Releasing Hormone Pulse Frequency and Width [PDF]

, 2014
Gonadotropin-releasing hormone (GnRH) is secreted in brief pulses that stimulate synthesis and secretion of pituitary gonadotropin hormones and thereby mediate control of reproduction.
Armstrong, Armstrong, Armstrong, Armstrong, Barrell, Belchetz, Bliss, Bliss, Burger, Bédécarrats, Cardenas, Caunt, Caunt, Caunt, Chuderland, Ciccone, Clayton, Crowley, Cullen, Durham, Ferris, Haisenleder, Haisenleder, Kanasaki, Lawson, Markevich, Marshall, Marshall, Millar, Moenter, Naor, O'Byrne, Padmanabhan, Purvis, Reiss, Savoy-Moore, Shupnik, Sisk, Tomida, Tsaneva-Atanasova, Tsutsumi, Williams   +41 more
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Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
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Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP [PDF]

, 1999
Raf-1 phosphorylates and activates MEK-1, a kinase that activates the extracellular signal regulated kinases (ERK). This kinase cascade controls the proliferation and differentiation of different cell types.
A Minden, A Sewing, AD Catling, B Hallberg, CJ Marshall, D Woods, DK Grandy, DK Morrison, DW Rose, F Schoentgen, Ferrell, J. E. Jr, Ferrell, J. E. Jr, H Mischak, HJ Schaeffer, JT Bruder, KL Guan, M Kortenjann, OV Gjorup, RM Lavbinsky, RM Tombes, S Häfner, S Li, SA Moodie, UR Rapp, W Kolch, W Kolch   +25 more
core   +1 more source

Nitric oxide production by Biomphalaria glabrata haemocytes: effects of Schistosoma mansoni ESPs and regulation through the extracellular signal-regulated kinase pathway [PDF]

, 2009
BACKGROUND: Schistosoma mansoni uses Biomphalaria glabrata as an intermediate host during its complex life cycle. In the snail, the parasite initially transforms from a miracidium into a mother sporocyst and during this process excretory-secretory ...
Davies, Angela J, Kirk, Ruth S, Rollinson, David, Walker, Anthony J, Zahoor, Zahida   +4 more
core   +3 more sources

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

MAPK-ERK Pathway

International Journal of Molecular Sciences, 2023
The name extracellular signal-regulated kinase (ERK) was first used for a cell cycle regulating Ser/Thr protein kinase cloned in mammalian cells [...]
openaire   +2 more sources