Results 41 to 50 of about 511,445 (325)
Animal Cells and Systems, 2020 Activin, a member of the transforming growth factor (TGF-β) superfamily, induces mesoderm, endoderm and neuro-ectoderm formation in Xenopus embryos. Despite several previous studies, the complicated gene regulatory network and genes involved in this ...
Zobia Umair +9 more
doaj +1 more source
Acta Pharmaceutica, 2021 Renal cell carcinoma (RCC) is generally acknowledged as the most resistant primary malignancy unresponsive to conventional radiotherapy and chemotherapy treatments.
Huang Shuaishuai +5 more
doaj +1 more source
Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]
, 2009 We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon +54 more
core +3 more sources
p38 Mitogen-activated Protein Kinase Regulates Oscillation of Chick Pineal Circadian Clock [PDF]
, 2003 Extracellular signal-regulated kinase (ERK) and p38 are members of the mitogen-activated protein kinase (MAPK) family, and in some cases these kinases serve for closely related cellular functions within a cell. In a wide range of animal clock structures,
Fukada, Yoshitaka +4 more
core +1 more source
Radiology and Oncology, 2019 Endometrial adenocarcinoma (EAC) is one of the most commonly diagnosed gynaecological malignancies among female population of the developed countries. DUSP6 is a negative regulator of ERK signaling, which is a molecular switch involved in MAPK signaling ...
Fan Ming-Jun +5 more
doaj +1 more source
Cancer Biology & Therapy, 2022 The tumor recurrence and drug resistance of hepatocellular carcinoma (HCC) threatened patients a lot. The mechanism should be further explored. The information of expression status and survival were available in public databases.
Hanpu Zhang +7 more
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Cancer Biology & Medicine, 2022 Objective: PD-L1 and PD-L2 expression levels determine immune evasion and the therapeutic efficacy of immune checkpoint blockade. The factors that drive inducible PD-L1 expression have been extensively studied, but mechanisms that result in constitutive ...
Panpan Ma +12 more
doaj +1 more source
Joint interpretation of AER/FGF and ZPA/SHH over time and space underlies hairy2 expression in the chick limb [PDF]
, 2012 Embryo development requires precise orchestration of cell proliferation and differentiation in both time and space. A molecular clock operating through gene expression oscillations was first described in the presomitic mesoderm (PSM) underlying periodic ...
Andrade, Raquel P. +2 more
core +3 more sources
Modeling Semantic Plausibility by Injecting World Knowledge
, 2018 Distributional data tells us that a man can swallow candy, but not that a man can swallow a paintball, since this is never attested. However both are physically plausible events.
Durrett, Greg, Erk, Katrin, Wang, Su
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Dinkum Sands — a recently foundered Arctic island [PDF]
, 2005 Dinkum Sands was mapped in 1949 as a small island, one link in a 95-km-long chain of barrier islands near Prudhoe Bay, Alaska. Questions about its status as an Arctic island and the submerged land ownership led to a Federal/State joint monitoring program
Reimnitz, Erk
core +1 more source