Results 61 to 70 of about 1,604 (142)

RNA therapy for oncogenic NRAS-driven naevi induces apoptosis [PDF]

RAS proteins regulate cell division, differentiation and apoptosis via multiple downstream effector pathways. Oncogenic RAS variants are the commonest drivers in cancers, however they also drive many benign lesions predisposing to malignancy, such as ...
Baird, William, Barberan-Martin, Sara, Bennett, Dorothy C, Bryant, Dale, Demetriou, Charalambos, Hart, Stephen, Jones, Phoebe, Kinsler, Veronica A, Knöpfel, Nicole, Maeshima, Ruhina, Michailidis, Fanourios, Pittman, Alan, Polubothu, Satyamaanasa, Rabii, Mohammad, Riachi, Melissa, Sauvadet, Aimie, Torres, Ignacio Del Valle, Zecchin, Davide   +17 more
core   +4 more sources

14‐3‐3σ restricts YY1 to the cytoplasm, promoting therapy resistance, and tumor progression in colorectal cancer

International Journal of Cancer, Volume 156, Issue 3, Page 623-637, 1 February 2025.
What's new? 14‐3‐3σ functions as an oncogene in colorectal cancer and is associated with therapy resistance. However, the underlying mechanisms remain unclear. Here, the authors show that 14‐3‐3σ restricts the localization of the transcription factor YY1 to the cytoplasm, preventing it from repressing genes of the unfolded protein response pathway ...
Amol Lonare, Kumarkrishna Raychaudhuri, Sanket Shah, Gifty Madhu, Anoushka Sachdeva, Sneha Basu, Rahul Thorat, Sanjay Gupta, Sorab N. Dalal   +8 more
wiley   +1 more source

Emerging role of IRE1α in vascular diseases

Journal of Cell Communication and Signaling, Volume 18, Issue 4, December 2024.
The IRE1α signaling pathway plays a critical role in the pathology of various vascular diseases. Abstract A mounting body of evidence suggests that the endoplasmic reticulum stress and the unfolded protein response are involved in the underlying mechanisms responsible for vascular diseases. Inositol‐requiring protein 1α (IRE1α), the most ancient branch
Jia Shi, Fan He, Xiaogang Du
wiley   +1 more source

CCR1 as a therapeutic target in multiple myeloma: preventing tumour dissemination and therapeutic resistance [PDF]

, 2020
Multiple myeloma (MM) is a haematological malignancy characterised by the clonal proliferation of plasma cells (PC) within the bone marrow (BM). While the introduction of novel therapies, such as the proteasome inhibitor bortezomib, has greatly improved ...
Zeissig, Mara Natasha
core  

Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

Medicinal Research Reviews, Volume 44, Issue 6, Page 2472-2509, November 2024.
Abstract Previously, lysosomes were primarily referred to as the digestive organelles and recycling centers within cells. Recent discoveries have expanded the lysosomal functional scope and revealed their critical roles in nutrient sensing, epigenetic regulation, plasma membrane repair, lipid transport, ion homeostasis, and cellular stress response ...
Yuchen He, Yishu Fan, Xenab Ahmadpoor, Yumin Wang, Zhong Alan Li, Weihong Zhu, Hang Lin   +6 more
wiley   +1 more source

Myeloid ectopic viral integration site 2 accelerates the progression of Alzheimer's disease

Aging Cell, Volume 23, Issue 10, October 2024.
MEIS2 promotes amyloid cleavage of β amyloid precursor protein through transcriptional regulation of BACE1. Abstract Amyloid plaques, a major pathological hallmark of Alzheimer's disease (AD), are caused by an imbalance between the amyloidogenic and non‐amyloidogenic pathways of amyloid precursor protein (APP).
Yuting Cui, Xiaomin Zhang, Jing Liu, Yuli Hou, Qiao Song, Min Cao, Jingjing Zhang, Xiaoling Wang, Congcong Liu, Peichang Wang, Yaqi Wang   +10 more
wiley   +1 more source

Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus [PDF]

金沢大学博士(医学）博士論文　要旨Abstract/本文Full 以下に掲載：Cellular and Molecular Gastroenterology and Hepatology 16(2) pp.263-286 2023. Elsevier. 共著者：Masashi Nishikawa, Hikari Okada, Kazunori Kawaguchi, Tetsuro Shimakami, Kouki Nio, Kuniaki Arai, Tatsuya Yamashita, Motoko ...
NISHIKAWA MASASHI, 西川 昌志
core   +1 more source

IRE1α pathway: A potential bone metabolism mediator

Cell Proliferation, Volume 57, Issue 10, October 2024.
Numerous prospective avenues exist for research on the IRE1α pathway. The IRE1α pathway can regulate osteogenesis, chondrogenesis, and osteoclatogenesis. IREI α is implicated in development of osteoblast, osteoclast, and chondrocyte and bone‐immune interaction.
Chengbo Yu, Zhixiang Zhang, Li Xiao, Mi Ai, Ying Qing, Zhixing Zhang, Lianyi Xu, Ollie Yiru Yu, Yingguang Cao, Yong Liu, Ke Song   +10 more
wiley   +1 more source

Effect of hypoxia and ischemia on the expression of phosphofructokinase-1 and lactate dehydrogenase genes in glioma U87 cells with ERN1 knockdown

Физика живого, 2011
Клітини злоякісних пухлин переважно використовують гліколіз для задоволення своїх підвищених енергетичних та біосинтетичних потреб. Ми досліджували вплив гіпоксії та ішемії, що є важливими факторами неоваскуляризації та росту пухлин, на експресію генів таких ензимів гліколізу як фосфофруктокіназа-1 (PFKL, PFKM і PFKP) та лактатдегідрогеназа (LDHA і ...
Marunych, R., Minchenko, D., Kubaichuk, K., Bakalets, T., Minchenko, O.   +4 more
openaire   +1 more source

The emerging roles of UFMylation in the modulation of immune responses

Clinical and Translational Medicine, Volume 14, Issue 9, September 2024.
UFMylation regulates cGAS‐STING and RIG‐I pathways to defend pathogens. UFMylation regulates the PD‐1/PD‐L1 checkpoint. UFMylation component UFBP1 regulates the function of B cells. UFMylation regulates inflammation‐related pathways (e.g., TLRs and NF‐κB).
Zhengyan Liang, Rongxuan Ning, Zhaoxiang Wang, Xia Kong, Yubin Yan, Yafei Cai, Zhiwei He, Xin‐guang Liu, Yongkang Zou, Junzhi Zhou   +9 more
wiley   +1 more source