Results 81 to 90 of about 1,604 (142)

Advancing prostate cancer therapies through integrative multi-omics:It’s about time [PDF]

, 2023
Linder, Simon
core   +2 more sources

IRE1α Determines Ferroptosis Sensitivity Through Regulation of Glutathione Synthesis [PDF]

Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein ...
Bam, Rakesh, Gan, Boyi, Guo, Youming, Iwawaki, Takao, Jiang, Dadi, Koong, Albert C, Lee, Hyemin, Wang, Liang, Wang, Tianyu, Xia, Ling, Yan, Yuelong, Yang, Zhifen   +11 more
core   +1 more source

Dimethyl sulfoxide reduces hepatocellular lipid accumulation through autophagy induction [PDF]

, 2012
Induction of autophagy is known not only to regulate cellular homeostasis but also to decrease triglyceride accumulation in hepatocytes. The aim of this study is to investigate whether DMSO (dimethyl sulfoxide) has a beneficial role in free fatty acid ...
강은석, 송선옥, 송영미, 이병완, 이현철, 차봉수   +5 more
core  

A multimodal screening platform for endogenous dipeptide repeat proteins in C9orf72 patient iPSC neurons [PDF]

Repeat expansions in C9orf72 are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Repeat-associated non-AUG (RAN) translation generates neurotoxic dipeptide repeat proteins (DPRs).
Armstrong, E, Atilano, ML, Awan, AR, Carcolé, M, Chandran, S, Dobbs, HK, Fisher-Ward, CL, Flower, M, Fratta, P, Giblin, A, Gittings, LM, Goulden, RA, Gupta, Y, Hölbling, BV, Isaacs, AM, Katona, E, Kempthorne, L, Marchi, PM, Mikheenko, A, Mizielinska, S, O'Brien, N, Partridge, L, Ruepp, MD, Selvaraj, BT, Tabrizi, SJ, Ureña, E, Vaizoglu, D, Whiting, P, Wilson, KM   +28 more
core  

Understanding the Role of Fatty Acid Metabolism in Hematological Malignancies Through the Lens of the Acyl-COA Synthetase Long Chain Isozyme Family [PDF]

Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5-year survival rate of 60%. Obesity correlates with increased incidence of MM and high body mass index correlates with a poor treatment response.
Murphy, Connor
core   +1 more source

The MicroRNA390/TAS3 Pathway Mediates Symbiotic Nodulation and Lateral Root Growth [PDF]

, 2019
Legume roots form two types of postembryonic organs, lateral roots and symbiotic nodules. Nodule formation is the result of the interaction of legumes with rhizobia and requires the mitotic activation and differentiation of root cells as well as an ...
Blanco, Flavio Antonio, Bustos-Sanmamed, Pilar, Crespi, Martín, Hobecker, Karen Vanesa, Kirankuma,r S. Mysore,, Reynoso, Mauricio Alberto, Wen, J., Zanetti, María Eugenia   +7 more
core  

IRE1α protects against osteoarthritis by regulating progranulin-dependent XBP1 splicing and collagen homeostasis. [PDF]

Exp Mol Med, 2023
Liang L, Zhang F, Feng N, Kuang B, Fan M, Chen C, Pan Y, Zhou P, Geng N, Li X, Xian M, Deng L, Li X, Kuang L, Luo F, Tan Q, Xie Y, Guo F.   +17 more
europepmc   +1 more source

DDX3X promotes endoplasmic reticulum protein reprogramming via interaction with ERN1 to amplify cerebral ischemia/reperfusion injury. [PDF]

Eur J Med Res
Du Q, Liu Y, Guo J.
europepmc   +1 more source

IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models. [PDF]

Int J Mol Sci, 2023
Ferraro F, Steinle A, Narasimhan H, Bleilevens A, Stolzenberg PM, Braunschweig T, Stickeler E, Maurer J.   +7 more
europepmc   +1 more source

SPLiCR-seq: A CRISPR-Based Screening Platform for RNA splicing Identifies Novel Regulators of IRE1α-XBP1 Signaling Under ER Stress. [PDF]

Nat Commun
Ying Q, Chen Y, Shen L, Xu Y, Tian R.
europepmc   +1 more source