Results 141 to 150 of about 1,947 (173)
Molecular Mechanisms and Pathophysiological Significance of Eryptosis
International Journal of Molecular Sciences, 2023 Despite lacking the central apoptotic machinery, senescent or damaged RBCs can undergo an unusual apoptosis-like cell death, termed eryptosis. This premature death can be caused by, or a symptom of, a wide range of diseases. However, various adverse conditions, xenobiotics, and endogenous mediators have also been recognized as triggers and inhibitors ...
Sabiha Fatima, Mohammad Alfhili
exaly +4 more sources
Journal of Clinical Medicine, 2022 Background: Peritonitis and exit site infections are the main complications of patients treated with peritoneal dialysis (PD). Erythrocytes (red blood cells—RBCs) are very sensitive cells, and they are characterized by eryptosis (programmed cell death).
Grazia Maria, Mónica Zanella
exaly +4 more sources
Enhanced Eryptosis Following Gramicidin Exposure [PDF]
Toxins, 2015 The peptide antibiotic and ionophore gramicidin has previously been shown to trigger apoptosis of nucleated cells. In analogy to apoptosis, the suicidal death of erythrocytes or eryptosis involves cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface. Triggers of eryptosis include oxidative stress,
Florian Lang +2 more
exaly +5 more sources
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Current Medicinal Chemistry, 2017
Prior to senescence, erythrocytes may experience injury, which compromises their integrity and thus triggers suicidal erythrocyte death or eryptosis. This mechanism is characterised by cell shrinkage, cell membrane blebbing, and cell membrane phospholipid scrambling after phosphatidylserine exposure on the cell surface that is identified by macrophages,
Caterina Faggio, Marilena Briglia
exaly +4 more sources
Prior to senescence, erythrocytes may experience injury, which compromises their integrity and thus triggers suicidal erythrocyte death or eryptosis. This mechanism is characterised by cell shrinkage, cell membrane blebbing, and cell membrane phospholipid scrambling after phosphatidylserine exposure on the cell surface that is identified by macrophages,
Caterina Faggio, Marilena Briglia
exaly +4 more sources
Mechanisms and Significance of Eryptosis
Antioxidants & Redox Signaling, 2006Suicidal death of erythrocytes (eryptosis) is characterized by cell shrinkage, membrane blebbing, activation of proteases, and phosphatidylserine exposure at the outer membrane leaflet. Exposed phosphatidylserine is recognized by macrophages that engulf and degrade the affected cells. Eryptosis is triggered by erythrocyte injury after several stressors,
Florian, Lang +4 more
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Stimulation of Hemolysis and Eryptosis by β-Caryophyllene Oxide
Life, 2023 Background: Eryptosis stimulated by anticancer drugs can lead to anemia in patients. β-caryophyllene oxide (CPO) is an anticancer sesquiterpene present in various plants; however, its effect on the structure and function of human red blood cells (RBCs) remains unexplored.
Mohammad Alfhili, Jawaher Alsughayyir
exaly +4 more sources
Eryptosis triggered by bismuth
BioMetals, 2008Bismuth is used for multiple industrial purposes and in the treatment of several gastrointestinal diseases. Untoward effects of bismuth include anemia, which could, in theory, result from suicidal erythrocyte death or eryptosis. Hallmarks of eryptosis are cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the cell surface ...
Manuel, Braun +3 more
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Apoptosis and eryptosis: similarities and differences
Apoptosis, 2023Eryptosis is a regulated cell death (RCD) of mature erythrocytes initially described as a counterpart of apoptosis for enucleated cells. However, over the recent years, a growing number of studies have emphasized certain differences between both cell death modalities.
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Eryptosis: a driver of anemia in chronic kidney disease
Current Opinion in Nephrology & Hypertension, 2023Purpose of review Anemia, characterized by a reduction in red blood cell (RBC) count or hemoglobin concentration, commonly accompanies chronic kidney disease (CKD), significantly impacting patients’ quality of life. This review delves into the multifaceted nature of anemia in CKD, with a focus on novel mechanisms, particularly ...
Bissinger, R., Qadri, S.M., Artunc, F.
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