Results 151 to 160 of about 1,847 (171)

Eryptosis in Haemochromatosis: Implications for rheology

Clinical Hemorheology and Microcirculation, 2018
BACKGROUND: Haemochromatosis is an iron-storage disease with different genetic mutations, characterized by an increased intestinal absorption of iron, resulting in a deposition of excessive amounts of iron in parenchymal cells. When the iron is released in the blood, it is left in an unliganded form, where it can participate in Haber-Weiss and Fenton ...
Jeanette N, du Plooy, Janette, Bester, Etheresia, Pretorius   +2 more
openaire   +2 more sources

Eryptosis in autoimmune haemolytic anaemia

European Journal of Haematology, 2017
AbstractObjectiveHaemolysis and anaemia related to autoimmune haemolytic anaemia (AIHA) of warm type (wAIHA) and of cold type (cAIHA) are believed to be solely due to antibody and/or complement‐mediated destruction and clearance of red blood cells (RBCs). There is evidence that RBCs of affected patients may also undergo eryptosis, the suicidal death of
Thilo Bartolmäs, Beate Mayer, Abdelwahab H. Balola, Abdulgabar Salama   +3 more
openaire   +2 more sources

Enhanced Eryptosis Following Juglone Exposure

Basic & Clinical Pharmacology & Toxicology, 2014
AbstractJuglone, a quinone isolated from Juglans mandshurica Maxim, has previously been shown to be effective against malignancy. The effect is at least partially due to stimulation of suicidal death or apoptosis of tumour cells. On the other hand, juglone has been shown to counteract apoptosis, for example, of neurons.
CALABRÒ S., ALZOUBI K., BISSINGER R., JILANI K., FAGGIO, Caterina, LANG F.   +5 more
openaire   +3 more sources

Eryptosis Is Altered in Peritoneal Dialysis Patients

Blood Purification, 2019
<b><i>Background:</i></b> Red blood cells (RBCs) undergo programmed cell death known as eryptosis. Triggers of eryptosis include increased cytosolic Ca(2+) concentration, oxidative stress, osmotic shock, energy depletion and several uremic toxins.
Virzì GM, Milan Manani S, Clementi A, Castegnaro S, Brocca A3, Riello C, de Cal M, Giuliani A, Battaglia G, Crepaldi C, Ronco C   +10 more
openaire   +3 more sources

Casein kinase 1α mediates eryptosis: a review

Apoptosis, 2022
Eryptosis is a coordinated non-lytic cell death of erythrocytes characterized by cell shrinkage, cell membrane scrambling, Ca2+ influx, ceramide accumulation, oxidative stress, activation of calpain and caspases. Physiologically, it aims at removing damaged or aged erythrocytes from circulation.
Anton Tkachenko, Anatolii Onishchenko
openaire   +2 more sources

The emerging roles of eryptosis in liver diseases

Transfusion Clinique et Biologique, 2019
Erythrocytes undergo programmed cell death, similar to apoptosis, known as eryptosis. This process is a result of several factors including hyperosmolarity, oxidative stress, and exposure to xenobiotics, and is characterized by the breakdown of membrane phospholipid asymmetry, the clustering of band 3, and the generation of red blood cell-derived ...
Wei, Xu, Fang, Peng, Ying, Deng, Xuegong, Fan, Ning, Li   +4 more
openaire   +2 more sources

Triggering of eryptosis, the suicidal erythrocyte death, by phenoxodiol

Naunyn-Schmiedeberg's Archives of Pharmacology, 2019
Phenoxodiol is used for the treatment of malignancy. The substance is effective by triggering suicidal tumor cell death or apoptosis. At least in theory, phenoxodiol could similarly stimulate suicidal erythrocyte death or eryptosis. Eryptosis is characterized by cell shrinkage and breakdown of cell membrane asymmetry with phosphatidylserine ...
Fink M., Bhuyan A. A. M., Nurnberg B., Faggio C., Lang F.   +4 more
openaire   +3 more sources

Ceramide in the regulation of eryptosis, the suicidal erythrocyte death

Apoptosis, 2015
Similar to apoptosis of nucleated cells, erythrocytes may undergo eryptosis, a suicidal death characterized by cell shrinkage and phospholipid scrambling of the cell membrane leading to phosphatidylserine exposure at the cell surface. As eryptotic erythrocytes are rapidly cleared from circulating blood, excessive eryptosis may lead to anemia. Moreover,
Lang, Elisabeth, Bissinger, Rosi, Gulbins, Erich, Lang, Florian   +3 more
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Eryptosis in Health and Disease

Eryptosis is a tightly regulated form of programmed cell death, crucial for maintaining erythrocyte count in body circulation. Eryptosis is a physiological phenomenon however, when dysregulated or excessively activated, eryptosis can become pathogenic.
openaire   +1 more source

[Signal pathways of eryptosis-review].

Zhongguo shi yan xue ye xue za zhi, 2011
Erythrocytes are devoid of nuclei and mitochondria which are the crucial elements of apoptosis, so their programmed suicidal death is called eryptosis. Eryptosis is characterized by cell shrinkage, membrane blebbing, activation of proteases, and phosphatidylserine exposure.
Guo-Qiang, Bao, Ai-Zhong, Ju
openaire   +1 more source