Results 101 to 110 of about 33,348 (245)

Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag

Virology Journal, 2008
Background The ESCRT (endosomal sorting complex required for transport) machinery functions to sort cellular receptors into the lumen of the multivesicular body (MVB) prior to lysosomal degradation.
Valiathan Rajeshwari R, Resh Marilyn D
doaj   +1 more source

ESCRT recruitment to damaged lysosomes is dependent on the ATG8 E3-like ligases

bioRxiv
The endosomal sorting complex required for transport (ESCRT) machinery plays an essential role in the sealing of endolysosomal membranes damaged by pathogenic, chemical or physical stress.
Dale P. Corkery, Shuang Li, Deerada Wijayatunga, Laura K. Herzog, A. Knyazeva, Yao-Wen Wu   +5 more
semanticscholar   +1 more source

Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology [PDF]

, 2016
With advances in DNA sequencing technology, it is increasingly common and tractable to informatically look for genes of interest in the genomic databases of parasitic organisms and infer cellular states.
Aaron P. Turkewitz, Agop-Nersesian, Agop-Nersesian, Asaoka, Asaoka, Barlowe, Barth, Bashline, Baum, Bañuelos, Beck, Bennett, Biller, Blanc, Bonifacino, Bonifacino, Bradley, Braun, Bright, Briguglio, Briguglio, Buczynski, Cai, Cai, Cardona-López, Castillo-Romero, Charette, Chavrier, Chen, Chen, Choi, Chow, Christen M. Klinger, Chung, Cui, Dacks, Dacks, Dettmer, Di Rubbo, Dieckmann, Diekmann, Dutta, Ebine, Ebine, Elde, Elias, Elias, Elliott, Emily K. Herman, Essid, Ezougou, Fan, Faso, Feraru, Field, Field, Field, Fitch, Francia, Fuji, Gabernet-Castello, Gadeyne, Gao, Gao, Giansanti, Gillingham, Gotthardt, Gotthardt, Haas, Hall, Harding, Harper, Harris, Hashiguchi, Henne, Herman, Hirst, Hirst, Hirst, Huotari, Il Kwon, Il Kwon, Inmaculada Ramirez-Macias, Isono, Jackson, Jacobs, Jaillais, Jimenez-Ruiz, Joel B. Dacks, Kang, Katsiarimpa, Kibria, Kim, Kleine-Vehn, Klinger, Knödler, Kolb, Komsic-Buchmann, Komsic-Buchmann, Koonin, Koumandou, Koumandou, Krai, Kremer, Kumar, Lee, Lefkir, Lefkir, Leung, Lunn, López-Reyes, Macro, Manil-Segalén, Manna, Manna, Marion, Mark C. Field, Mattei, McGugan, Mercanti, Miranda, Miras, Mitra, Morrison, Munch, Müller-Taubenberger, Nakada-Tsukui, Neuhaus, Ngô, Ngô, Niemes, Nishimura, Niyogi, Nodzynski, Nordmann, Okada, Okada, Oliviusson, Ouologuem, Pal, Pal, Park, Parkinson, Parussini, Perez-Linero, Pourcher, Preuss, Preuss, Price, Ralston, Rauch, Reider, Reyes, Rink, Rivero, Rivero, Robibaro, Robinson, Robinson, Rojas, Rupper, Rupper, Saito-Nakano, Sangaré, Scheuring, Schlacht, Schlacht, Seaman, Seaman, Shahriari, Shimada, Silverman, Silverman, Singh, Sloves, Sohn, Song, Sosa, Spitzer, Spitzer, Spitzer, Srinivasan, Stenmark, Szumlanski, Tarnita, Tazeh, Teh, Teixeira, Temesvari, Thole, Tomavo, Touz, Touz, Ueda, Ueda, Ulrich, Viotti, Wampfler, Wang, Wang, Welz, Wen, Winter, Woo, Wurmser, Yamaoka, Yamazaki, Yang, Zelazny, Zelazny, Zoltner   +210 more
core   +2 more sources

Defective axonal transport in motor neuron disease [PDF]

, 2007
Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas, Blair, Boillee, Bommel, Borchelt, Bowling, Brown, Bruijn, Burger, Cao, Cleveland, Cleveland, Duchen, Escurat, Evans, Fichera, Fliegner, Gaudette, Goldstein, Hadano, Hafezparast, Hazan, Hirokawa, Hirokawa, Hirokawa, Jablonka, Joshi, Kanai, Kaplan, Kieran, King, Kong, LaMonte, Levy, Ligon, Liu, Lo Giudice, Lu, Martin, Miki, Miki, Mitsumoto, Mitsumoto, Muglia, Munch, Nicholson, Nishimura, Okabe, Otomo, Parkinson, Parysek, Pasinelli, Patel, Proukakis, Puls, Puls, Quenneville, Rao, Reid, Reid, Reid, Rosen, Ross, Rowland, Sanderson, Schmitt-John, Shaw, Shibata, Siegel, Song, Teuchert, Troy, Vallee, Weber, Williamson, Wood, Xia, Zhao   +77 more
core   +1 more source

Molecular crosstalk via exosomes in lung cancer progression

Interdisciplinary Medicine, EarlyView.
“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan   +3 more
wiley   +1 more source

A unique role for the host ESCRT proteins in replication of Tomato bushy stunt virus. [PDF]

PLoS Pathogens, 2009
Plus-stranded RNA viruses replicate in infected cells by assembling viral replicase complexes consisting of viral- and host-coded proteins. Previous genome-wide screens with Tomato bushy stunt tombusvirus (TBSV) in a yeast model host revealed the ...
Daniel Barajas, Yi Jiang, Peter D Nagy
doaj   +1 more source

ESCRT disruption provides evidence against trans-synaptic signaling via extracellular vesicles

Journal of Cell Biology
ESCRT depletion disrupts synaptic extracellular vesicle (EV) release without affecting signaling by several EV cargoes. EVs are phagocytosed by adjacent cells, and ESCRT disruption causes compensatory autophagy.
Erica C. Dresselhaus, Kathryn P Harris, Cassandra R Blanchette, Kate Koles, Steven J. Del Signore, Matthew F Pescosolido, Biljana Ermanoska, Mark Rozencwaig, Rebecca C Soslowsky, Michael J. Parisi, Bryan A Stewart, Timothy J. Mosca, A. Rodal   +12 more
semanticscholar   +1 more source

The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility. [PDF]

, 2016
BackgroundThe p6 region of the HIV-1 structural precursor polyprotein, Gag, contains two motifs, P7TAP11 and L35YPLXSL41, designated as late (L) domain-1 and -2, respectively.
Anastos, Kathryn, Burger, Harold, Carter, Carol A, Chen, Benjamin K, Chen, Chaoping, Durham, Natasha D, Foley, Brian, Kemal, Kimdar Sherefa, Kemp, Brittney R, Li, Hongru, Machihara, Satoshi, Shi, Binshan, Simon, Viviana, Watanabe, Susan M, Weiser, Barbara   +14 more
core   +1 more source

Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition

PROTEOMICS, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs) to the EMT process, a proteome analysis of MBRs released from Madin–Darby canine kidney (MDCK) cells and
Adnan Shafiq, Alin Rai, Rong Xu, Maoshan Chen, Wittaya Suwakulsiri, David W. Greening, Richard J. Simpson   +6 more
wiley   +1 more source

CHMP4C: A novel regulator of the mitotic spindle checkpoint

Molecular & Cellular Oncology, 2018
The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for transport
Eleni Petsalaki, George Zachos
doaj   +1 more source