Results 61 to 70 of about 5,623,526 (302)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Regulatory effects of blood constituents on the function and metabolism of the cat brain in perfusion ezperiments. Brain perfusion with artificial blood containing low molecular dextran and amino acids [PDF]

, 1967
As a link in a series of studies on the effects of blood constituents on the brain function by means of brain perfusion, we used four kinds of artificial blood; namely, the blood containing a low molecular dextran, one containing glutamic acid, one ...
Nakashima, Yoshihiko, Watanabe, Shosuke, Okumura, Nikichi, Edamatsu, Kazuyasu, Otsuki, Saburo, Morimitsu, Junsuke   +5 more
core   +1 more source

Serum Amino Acids in Association with Prevalent and Incident Type 2 Diabetes in A Chinese Population

Metabolites, 2019
We aimed to simultaneously examine the associations of both essential and non-essential amino acids with both prevalent and incident type 2 diabetes in a Chinese population.
Yonghai Lu, Yeli Wang, Xu Liang, Li Zou, Choon Nam Ong, Jian-Min Yuan, Woon-Puay Koh, An Pan   +7 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Appendix C. Principal component analysis of essential amino acids.

, 2016
Principal component analysis of essential amino ...
Thomas Larsen (202163), C. Anela Choy (116362), Karen E. Arthur (163004), Shaleyla Kelez (234005), Brian N. Popp (116374)   +4 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Considerations on amino acid patterns in the natural felid diet: a review

Frontiers in Veterinary Science
Amino acids are essential for the growth, development, and reproduction of carnivores. This literature review summarizes the amino acid patterns of different raw diets including whole prey, body tissue and muscle for felids under human care.
Mengmeng Sun, Annelies De Cuyper, Ellen S. Dierenfeld, Geert P. J. Janssens   +3 more
doaj   +1 more source

Amino and fatty acids composition of olive stones for the discrimination of 'Olea europaea' subsp. 'europaea' varieties

Mediterranean Botany, 2020
Few studies have reported the relationship between wild (Olea europaea L. subsp. europaea var. sylvestris) and cultivated (Olea europaea L. subsp. europaea var. europaea) olive trees by using diverse markers.
Hédia Hannachi, Mohamed Ali Benabderrahim, Walid Elfalleh, Rongchun Wang, Ma Ying   +4 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source