Results 71 to 80 of about 1,982 (172)

Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis [PDF]

, 2017
Aberrant silencing of genes by DNA methylation contributes to cancer, yet how this process is initiated remains unclear. Using a murine model of inflammation-induced tumorigenesis, we tested the hypothesis that inflammation promotes recruitment of ...
Ashley R. Maiuri, Caitlin M. Kamplain, Christina E. DeStefano Shields, Cynthia L. Sears, Douglas B. Rusch, Heather M. O'Hagan, Michael Peng, Ram Podicheti, Shruthi Sriramkumar   +8 more
core   +1 more source

Photodynamic therapy of cancer‐associated infections

Photochemistry and Photobiology, Volume 101, Issue 4, Page 833-845, July/August 2025.
Pathogens can be involved in tumor initiation, promotion and progression through different mechanisms, and their treatment can prevent new cancer cases, improve outcomes, and revert poor‐prognostic phenotypes. Photodynamic therapy (PDT) successfully treats different types of cancers and infections, and, therefore, has a unique potential to address ...
Giulia Kassab, Juan Chen, Gang Zheng
wiley   +1 more source

The tempered spectrum of a real spherical space [PDF]

, 2017
Let G/H be a unimodular real spherical space which is either absolutely spherical or wave-front. It is shown that every tempered representation of G/H embeds into a relative discrete series of a boundary degeneration of G/H. If in addition G/H is of wave-
Knop, Friedrich, Krötz, Bernhard, Schlichtkrull, Henrik   +2 more
core   +2 more sources

The Roles of Dietary Bioactive Compounds in Alleviating Inflammatory Bowel Disease‐Associated Colorectal Cancer

Food Science &Nutrition, Volume 13, Issue 6, June 2025.
This article summarizes the molecular characteristics and mechanisms of the AOM/DSS‐induced CAC animal model, and reports on the preventive and therapeutic effects and mechanisms of phenolic compounds, flavonoids, terpenoids, polysaccharides, basic alkaloids, and other food extracts in preclinical trials for AOM/DSS‐induced CAC.
Jin‐Wei Zhao, Wei‐Yi Zhao, Zhong‐Yang Yu   +2 more
wiley   +1 more source

A Major Asymmetric Dust Trap in a Transition Disk

, 2013
The statistics of discovered exoplanets suggest that planets form efficiently. However, there are fundamental unsolved problems, such as excessive inward drift of particles in protoplanetary disks during planet formation.
Birnstiel, Til, Brown, Joanna M., Bruderer, Simon, Dullemond, Cornelis P., Geers, Vincent, Herczeg, Gregory J., Mathews, Geoffrey S., Pinilla, Paola, Schmalzl, Markus, van der Marel, Nienke, van Dishoeck, Ewine F., van Kempen, Tim A.   +11 more
core   +1 more source

Colorectal carcinogenesis: an archetype of gut microbiota-host interaction [PDF]

, 2018
Sporadic colorectal cancer (CRC) remains a major cause of worldwide mortality. Epidemiological evidence of markedly increased risk in populations that migrate to Western countries, or adopt their lifestyle, suggests that CRC is a disease whose aetiology ...
Alexander, James L, Kinross, James, Marchesi, Julian, Pouncey, Anna L, Scott, Alasdair J, Teare, Julian   +5 more
core   +2 more sources

Modeling cancer–microbiome interactions in vitro: A guide to co‐culture platforms

International Journal of Cancer, Volume 156, Issue 11, Page 2053-2067, 1 June 2025.
Abstract The biology of cancer is characterized by an intricate interplay of cells originating not only from the tumor mass, but also its surrounding environment. Different microbial species have been suggested to be enriched in tumors and the impacts of these on tumor phenotypes is subject to intensive investigation.
Kamil Moskal, Nimisha Khurana, Luisa Siegert, Ye Seul Lee, Hans Clevers, Eran Elinav, Jens Puschhof   +6 more
wiley   +1 more source

Heterogeneity of Intratumoral Microbiota Within the Tumor Microenvironment and Relationship to Tumor Development

Med Research, Volume 1, Issue 1, Page 32-61, June 2025.
Mutual shaping of tumor microbiota and TME. Intratumoral microbiota—comprising diverse bacteria, fungi, viruses, and intracellular organisms—play critical and dynamic roles in shaping the tumor microenvironment (TME). Their spatial and compositional diversity contributes to both intratumoral and intertumoral heterogeneity, influencing immune modulation
Zhifei Gao, Aimin Jiang, Zizhuo Li, Lingxuan Zhu, Weiming Mou, Weitao Shen, Peng Luo, Bufu Tang, Jian Zhang, Anqi Lin   +9 more
wiley   +1 more source

The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review

Advanced Science, Volume 12, Issue 18, May 15, 2025.
This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong, Jin Jiang, Muhammad Hussain, Haoxuan Zhang, Ling Chen, Rongfa Guan   +5 more
wiley   +1 more source

A review of the role of enterotoxigenic Bacteroides fragilis in the development of colorectal cancer

Basic & Clinical Cancer Research
Enterotoxigenic Bacteroides fragilis (ETBF) plays a significant role in the development and progression of colorectal cancer (CRC) through the production of Bacteroides fragilis toxin (BFT). This toxin activates Wnt, NF-κB, and STAT3 signaling pathways,
Abolfazl Jafari-Sales, Maryam Farahnaki-Sadabadi, Elham Nozohour-Leilabadi, Negin Yagoubi Azar, Maryam Safari, Mehrdad Pashazadeh   +5 more
doaj   +1 more source