Mutations and insights into the molecular mechanisms of resistance of Mycobacterium tuberculosis to first-line [PDF]
Genetics and Molecular Biology, 2023 Genetically antimicrobial resistance in Mycobacterium tuberculosis is currently one of the most important aspects of tuberculosis, considering that there are emerging resistant strains for almost every known drug used for its treatment.
Nicolas de Oliveira Rossini +1 more
doaj +1 more source
Quantifying Isoniazid Levels in Small Hair Samples: A Novel Method for Assessing Adherence during the Treatment of Latent and Active Tuberculosis. [PDF]
, 2016 BackgroundTuberculosis (TB) is the leading cause of death from an infectious pathogen worldwide and the most prevalent opportunistic infection in people living with HIV.
Bacchetti, Peter +6 more
core +1 more source
Treatment outcomes for children with multidrug-resistant tuberculosis: a systematic review and meta-analysis [PDF]
, 2012 BACKGROUND: Paediatric multidrug-resistant (MDR) tuberculosis is a public health challenge of growing concern, accounting for an estimated 15% of all global cases of MDR tuberculosis. Clinical management is especially challenging, and recommendations are
Abubakar +42 more
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Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain [PDF]
, 2015 The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a
Balloux, Francois +6 more
core +4 more sources
Ethambutol induced toxic optic neuropathy in HIV positive patients [PDF]
International Journal of Ophthalmology, 2013 AIM:To determine whether HIV and the use of antiretroviral therapy is a risk factor for the development of ethambutol toxic optic neuropathy. To describe the clinical course of ethambutol toxic optic neuropathy in patients with HIV and to identify ...
Hamzah Mustak, Graeme Rogers, Colin Cook
doaj +1 more source
Antimicrobial treatment improves mycobacterial survival in nonpermissive growth conditions [PDF]
, 2014 Antimicrobials targeting cell wall biosynthesis are generally considered inactive against nonreplicating bacteria. Paradoxically, we found that under nonpermissive growth conditions, exposure of Mycobacterium bovis BCG bacilli to such antimicrobials ...
Andrew, Peter W +12 more
core +2 more sources
Risk of acquired drug resistance during short-course directly observed treatment of tuberculosis in an area with high levels of drug resistance. [PDF]
, 2007 BACKGROUND: Data on the performance of standardized short-course directly observed treatment (DOTS) of tuberculosis (TB) in areas with high levels of drug resistance and on the potential impact of DOTS on amplification of resistance are limited ...
Cox +33 more
core +2 more sources
Recurrent Cutaneous Tuberculosis in an Immunocompetent 7-Year-Old Male [PDF]
, 2018 Cutaneous tuberculosis (TB) makes up a small proportion of the 10.4 million cases around the world. Although it is more commonly found in the developing world, cutaneous TB is rarely reported in the developed countries.
Austin, Dena +4 more
core +2 more sources
Туберкулез и болезни лёгких, 2017 Based on real-time allele-specific polymerase chain reaction, the ranges of potential mutations in codons of 306 and 405 of the embBgene in Mycobacterium tuberculosis associated with resistance to ethambutol were investigated.
Yu. S. Аlyapkinа +5 more
doaj +1 more source
Medication Complications in Extracorporeal Membrane Oxygenation. [PDF]
, 2017 The need for extracorporeal membrane oxygenation (ECMO) therapy is a marker of disease severity for which multiple medications are required. The therapy causes physiologic changes that impact drug pharmacokinetics.
Aebi +99 more
core +2 more sources