Results 41 to 50 of about 42,465 (246)

Benefits of Therapeutic Drug Monitoring of First Line Antituberculosis Drugs

Acta Medica Martiniana, 2020
Tuberculosis is an airborne infectious disease that remains a huge global health-related issue nowadays. Despite constant approvals of newly developed drugs, the use of first-line antituberculosis medicines seems reasonable in drug-susceptible ...
Prso K, Zidekova N, Dohal M, Porvaznik I, Prso M, Kertys M, Mokry J   +6 more
doaj   +1 more source

A Female Patient with Down Syndrome and Low-Penetrance Leber's Hereditary Optic Neuropathy. [PDF]

, 2014
We present the case of a 19-year-old female with a history of Down syndrome (DS) who was referred to our neuro-ophthalmology clinic for evaluation of Leber's hereditary optic neuropathy (LHON).
Frousiakis, Starleen E, Karanjia, Rustum, Pouw, Andrew E, Sadun, Alfredo A   +3 more
core   +3 more sources

Four-month moxifloxacin-based regimens for drug-sensitive tuberculosis [PDF]

, 2015
Supported by the Global Alliance for TB Drug Development with support from the Bill and Melinda Gates Foundation, the European and Developing Countries Clinical Trials Partnership, U.S. Agency for International Development, U.K.
Crook, Angela M., for the REMoxTB Consortium, Gillespie, Stephen H., McHugh, Timothy D., Mendel, Carl M., Meredith, Sarah K., Murray, Stephen R., Nunn, Andrew J., Pappas, Frances, Phillips, Patrick P.J.   +9 more
core   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2

Protein & Cell, 2020
Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its ...
Lu Zhang, Yao Zhao, Ruogu Gao, Jun Li, Xiuna Yang, Yan Gao, Wei Zhao, Sudagar S. Gurcha, Natacha Veerapen, Sarah M. Batt, Kajelle Kaur Besra, Wenqing Xu, Lijun Bi, Xian’en Zhang, Luke W. Guddat, Haitao Yang, Quan Wang, Gurdyal S. Besra, Zihe Rao   +18 more
doaj   +1 more source

Frequency of Codon 306 Mutations in embB Gene of Mycobacterium tuberculosis Resistant to Ethambutol: A Systematic Review and Meta-Analysis

International Journal of Preventive Medicine, 2020
Background: Ethambutol (EMB) resistance is a major concern in patients with tuberculosis (TB). The aim of this study was to determine the frequency rate of mutations in the embB 306 gene of Mycobacterium tuberculosis (M.
Bahman Mohammadi, Rashid Ramazanzadeh, Bijan Nouri, Samaneh Rouhi   +3 more
doaj   +1 more source

Mitochondrial Mutations in Ethambutol-Induced Optic Neuropathy

Frontiers in Cell and Developmental Biology, 2021
Background: Ethambutol-induced optic neuropathy (EON) is a well-recognized ocular complication in patients who take ethambutol as a tuberculosis treatment. The aim of the current study was to investigate the presence of mitochondrial mutations, including
Xiao-Hui Zhang, Xiao-Hui Zhang, Yue Xie, Quan-Gang Xu, Kai Cao, Ke Xu, Zi-Bing Jin, Yang Li, Shi-Hui Wei   +8 more
doaj   +1 more source

Drug-Resistant Tuberculosis--Current Dilemmas, Unanswered Questions, Challenges and Priority Needs [PDF]

, 2012
Tuberculosis was declared a global emergency by the World Health Organization (WHO) in 1993. Following the declaration and the promotion in 1995 of directly observed treatment short course (DOTS), a cost-effective strategy to contain the tuberculosis ...
Abubakar, Ibrahim, Atun, Rifat, Chakaya, Jeremiah, Cox, Helen, Ditiu, Lucica, Ford, Nathan, Grobusch, Martin, Hoelscher, Michael, Lawn, Stephen D., Maeurer, Markus, Marais, Ben, Mchugh, Timothy D., McNerney, Ruth, Memish, Ziad, Migliori, Giovanni-Battista, Mwaba, Peter, O'Grady, Justin, Pletschette, Michel, Ramsay, Andrew, Raviglione, Mario, Schito, Marco, Squire, S. Bertel, Swaminathan, Soumya, Zumla, Alimuddin   +23 more
core   +1 more source

Treatment outcome in children with nontuberculous mycobacterial lymphadenitis: A retrospective follow-up study

International Journal of Mycobacteriology, 2017
Introduction: Information on the long-term treatment outcome following nontuberculous mycobacterial (NTM) lymphadenitis is very limited. We performed a study to (a) compare cure rates following different initial treatment courses, (b) describe subsequent
Annicka Reuss, Sarah Drzymala, Barbara Hauer, Rüdiger von Kries, Walter Haas   +4 more
doaj   +1 more source

Isolated anal tuberculosis presenting as an anal fistula in an immunocompetent child

JPGN Reports, EarlyView.
Abstract Extra‐pulmonary tuberculosis accounts for less than 15% of all tuberculosis cases, while intestinal tuberculosis accounts for less than 1% of extra‐pulmonary forms of the disease. Abdominal organ involvement is more common, but extension to the ano‐perineal region is extremely rare.
Mariam Lagrine, Rabiy Elqadiry, Houda Nassih, Aicha Bourrahouat, Imane Ait Sab   +4 more
wiley   +1 more source