Results 41 to 50 of about 39,846 (186)

Benefits of Therapeutic Drug Monitoring of First Line Antituberculosis Drugs

Acta Medica Martiniana, 2020
Tuberculosis is an airborne infectious disease that remains a huge global health-related issue nowadays. Despite constant approvals of newly developed drugs, the use of first-line antituberculosis medicines seems reasonable in drug-susceptible ...
Prso K, Zidekova N, Dohal M, Porvaznik I, Prso M, Kertys M, Mokry J   +6 more
doaj   +1 more source

Mitochondrial Mutations in Ethambutol-Induced Optic Neuropathy

Frontiers in Cell and Developmental Biology, 2021
Background: Ethambutol-induced optic neuropathy (EON) is a well-recognized ocular complication in patients who take ethambutol as a tuberculosis treatment. The aim of the current study was to investigate the presence of mitochondrial mutations, including
Xiao-Hui Zhang, Xiao-Hui Zhang, Yue Xie, Quan-Gang Xu, Kai Cao, Ke Xu, Zi-Bing Jin, Yang Li, Shi-Hui Wei   +8 more
doaj   +1 more source

Biosynthesis of mycobacterial arabinogalactan: identification of a novel (13)arabinofuranosyltransferase [PDF]

, 2008
The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, such as Mycobacterium tuberculosis and is the target of several anti-tubercular drugs.
Alderwick, Luke J., Bai, Yu, Besra, Gurdyal S, Bhatt, Apoorva, Birch, Helen, Eggeling, Lothar, Krumbach, Karin, Lowary, Todd L., Rittmann, Doris, Singh, Albel   +9 more
core   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2

Protein & Cell, 2020
Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for anti-TB chemotherapy. Arabinosyltransferase EmbB, which catalyzes the transfer of arabinose from the donor decaprenyl-phosphate-arabinose (DPA) to its ...
Lu Zhang, Yao Zhao, Ruogu Gao, Jun Li, Xiuna Yang, Yan Gao, Wei Zhao, Sudagar S. Gurcha, Natacha Veerapen, Sarah M. Batt, Kajelle Kaur Besra, Wenqing Xu, Lijun Bi, Xian’en Zhang, Luke W. Guddat, Haitao Yang, Quan Wang, Gurdyal S. Besra, Zihe Rao   +18 more
doaj   +1 more source

Frequency of Codon 306 Mutations in embB Gene of Mycobacterium tuberculosis Resistant to Ethambutol: A Systematic Review and Meta-Analysis

International Journal of Preventive Medicine, 2020
Background: Ethambutol (EMB) resistance is a major concern in patients with tuberculosis (TB). The aim of this study was to determine the frequency rate of mutations in the embB 306 gene of Mycobacterium tuberculosis (M.
Bahman Mohammadi, Rashid Ramazanzadeh, Bijan Nouri, Samaneh Rouhi   +3 more
doaj   +1 more source

Potentiating the Anti-Tuberculosis Efficacy of Peptide Nucleic Acids through Combinations with Permeabilizing Drugs

Microbiology Spectrum, 2022
The emergence of antimicrobial resistance warrants for the development of improved treatment approaches. In this regard, peptide nucleic acids (PNAs) have shown great promise, exhibiting antibiotic properties through the targeting of cellular nucleic ...
Karishma Berta Cotta, Saptarshi Ghosh, Sarika Mehra   +2 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Treatment outcome in children with nontuberculous mycobacterial lymphadenitis: A retrospective follow-up study

International Journal of Mycobacteriology, 2017
Introduction: Information on the long-term treatment outcome following nontuberculous mycobacterial (NTM) lymphadenitis is very limited. We performed a study to (a) compare cure rates following different initial treatment courses, (b) describe subsequent
Annicka Reuss, Sarah Drzymala, Barbara Hauer, Rüdiger von Kries, Walter Haas   +4 more
doaj   +1 more source

Clinical Pharmacology Quality Assurance Program for Global HIV and Co‐Infection Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
When the acquired immunodeficiency syndrome emerged in the 1980s, the United States National Institutes of Health established research networks to conduct clinical trials with the pharmaceutical industry to identify effective antiretroviral therapeutics.
Robin DiFrancesco, Troy D. Wood, Raymond Cha, Jill S. Hochreiter, Susan L. Rosenkranz, Mona Farhad, Kyle R. Whitson, Connor E. Gould, Lauren E. Hill, Linda L. Hale, Philip H. Lindhorst, Diala Ghazal, Charlene R. Taylor, Madiha Quraishi, Suzanne M. Siminski, Yoninah Cramer, Heather L. Sprenger, Gene D. Morse   +17 more
wiley   +1 more source