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Neuroprotection by Mitochondrial NAD Against Glutamate-Induced Excitotoxicity [PDF]

Cells
Excitotoxicity is a pathological process that occurs in many neurological diseases, such as stroke or epilepsy, and is characterized by the extracellular accumulation of high concentrations of glutamate or other excitatory amino acids (EAAs ...
Bruna S. Paiva, Diogo Neves, Diogo Tomé, Filipa J. Costa, Inês C. Bruno, Diogo Trigo, Raquel M. Silva, Ramiro D. Almeida   +7 more
doaj   +2 more sources

Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection [PDF]

Cell Death and Disease
Excitotoxicity, aberrant function of survival pathways dependent on brain-derived neurotrophic factor (BDNF), and disruption of the Golgi complex are shared pathological hallmarks in relevant neurological diseases, including stroke.
Gema María Esteban-Ortega, Elena Torres-Campos, Margarita Díaz-Guerra   +2 more
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Enriched environment inhibits GLT-1 ubiquitination by downregulating SMURF1 to attenuate ischemic brain injury induced excitotoxicity [PDF]

Cell & Bioscience
Background Excitotoxicity induced by glutamate contributes significantly to ischemic brain injury. The role of enriched environment (EE) in promoting neurological recovery post-stroke is well-established, yet its impact on excitotoxicity remains unclear.
Yi Zhang, Wen Liu, Tao Huang, Lingling Liu, Xiuping Chen   +4 more
doaj   +2 more sources

Does umbelliferone protect primary cortical neuron cells against glutamate excitotoxicity [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021
Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has anti-oxidant, anti-infl ammatory, and neuroprotective eff ects.
Alper Kürşat DEMİRKAYA, Gülşah GÜNDOĞDU, Songül KARAKAYA, Şeymanur YILMAZ TAŞCI, Kemal Alp NALCI, Ahmet HACIMÜFTÜOĞLU   +5 more
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The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation

Frontiers in Molecular Neuroscience, 2023
Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine ...
Genhao Fan, Menglin Liu, Jia Liu, Yuhong Huang   +3 more
doaj   +1 more source

Restoration of Sarco/Endoplasmic Reticulum Ca2+-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca2+ Depletion

Frontiers in Pharmacology, 2022
Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2 ...
Wen Zhang, Wen Zhang, Wen Zhang, Fanghua Ye, Nan Pang, Nan Pang, Nan Pang, Miriam Kessi, Miriam Kessi, Miriam Kessi, Miriam Kessi, Juan Xiong, Juan Xiong, Juan Xiong, Shimeng Chen, Shimeng Chen, Shimeng Chen, Jing Peng, Jing Peng, Jing Peng, Li Yang, Li Yang, Li Yang, Fei Yin, Fei Yin, Fei Yin   +25 more
doaj   +1 more source

A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity

Molecules, 2022
Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness.
Dongli Zhuang, Rong Zhang, Haiyang Liu, Yi Dai   +3 more
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Various facets of excitotoxicity

Exploration of Neuroprotective Therapy, 2022
Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the central nervous system, it is also the most common ...
Talita Glaser, Jean Bezerra Silva, Guilherme A. Juvenal, Pedro Negrão Maiolini, Natalia Turrini, Lyvia Lintzmaier Petiz, Lucas Bonfim Marques, Deidiane Elisa Ribeiro, Qing Ye, Yong Tang, Henning Ulrich   +10 more
doaj   +1 more source

Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, 2020
Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss
Adam Armada-Moreira, Adam Armada-Moreira, Adam Armada-Moreira, Joana I. Gomes, Joana I. Gomes, Carolina Campos Pina, Carolina Campos Pina, Oksana K. Savchak, Oksana K. Savchak, Joana Gonçalves-Ribeiro, Joana Gonçalves-Ribeiro, Nádia Rei, Nádia Rei, Sara Pinto, Sara Pinto, Tatiana P. Morais, Robertta Silva Martins, Filipa F. Ribeiro, Filipa F. Ribeiro, Ana M. Sebastião, Ana M. Sebastião, Vincenzo Crunelli, Vincenzo Crunelli, Sandra H. Vaz, Sandra H. Vaz   +24 more
doaj   +1 more source

Molecular mechanisms of NMDA excitotoxicity in the retina

Scientific Reports, 2023
NMDA excitotoxicity, as a part of glutamate excitotoxicity, has been proposed to contribute significantly to many retinal diseases. Therefore, understanding mechanisms of NMDA excitotoxicity will provide further insight into the mechanisms of many ...
Galina Dvoriantchikova, Michelle Fleishaker, Dmitry Ivanov   +2 more
doaj   +1 more source