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Going the Extra (Synaptic) Mile: Excitotoxicity as the Road Toward Neurodegenerative Diseases
Frontiers in Cellular Neuroscience, 2020 Excitotoxicity is a phenomenon that describes the toxic actions of excitatory neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of glutamate receptors starts a cascade of neurotoxicity that ultimately leads to the loss
Adam Armada-Moreira +24 more
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Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders
Frontiers in Neural Circuits, 2021 Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the central and peripheral nervous systems. Other than the previously established signaling pathways of excitotoxicity, which depend on the excessive release of ...
Changyong Guo, Yao-Ying Ma, Yao-Ying Ma
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Frontiers in Neuroscience, 2021 Excitotoxicity has been implicated in many neurological disorders and is a leading cause of oxidative stress and neuroinflammation in the nervous system.
Kathleen F. Holton
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Neuroprotection by Mitochondrial NAD Against Glutamate-Induced Excitotoxicity [PDF]
CellsExcitotoxicity is a pathological process that occurs in many neurological diseases, such as stroke or epilepsy, and is characterized by the extracellular accumulation of high concentrations of glutamate or other excitatory amino acids (EAAs ...
Bruna S. Paiva +7 more
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Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
Frontiers in Neuroscience, 2019 Glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be ...
Irina Krasil’nikova +10 more
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Mechanism of Zinc Excitotoxicity: A Focus on AMPK
Frontiers in Neuroscience, 2020 Over the last 20 years, it has been shown that complex signaling cascades are involved in zinc excitotoxicity. Free zinc rapidly induces PKC activation, which causes reactive oxygen species (ROS) production at least in part through NADPH oxidase. It also
Yang-Hee Kim, Jae-Won Eom, Jae-Young Koh
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eLife, 2019 Overproduction of reactive oxygen species (ROS) is known to mediate glutamate excitotoxicity in neurological diseases. However, how ROS burdens can influence neural circuit integrity remains unclear.
Jhan-Jie Peng +5 more
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The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific
Frontiers in Neuroscience, 2019 Retinal ganglion cells (RGCs) are the only output neurons that conduct visual signals from the eyes to the brain. RGC degeneration occurs in many retinal diseases leading to blindness and increasing evidence suggests that RGCs are susceptible to various ...
Ian Christensen +10 more
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Does umbelliferone protect primary cortical neuron cells against glutamate excitotoxicity [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Glutamate is the major excitatory neurotransmitter in the central nervous system. Excessive glutamate is known to cause excitotoxicity. Umbelliferone is a coumarin derivative compound and has anti-oxidant, anti-infl ammatory, and neuroprotective eff ects.
Alper Kürşat DEMİRKAYA +5 more
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Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
Translational Neurodegeneration, 2022 Glutamate is the most commonly engaged neurotransmitter in the mammalian central nervous system, acting to mediate excitatory neurotransmission. However, high levels of glutamatergic input elicit excitotoxicity, contributing to neuronal cell death ...
M. Verma, Britney N. Lizama, C. Chu
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