Results 91 to 100 of about 46,919 (266)

The Olivocerebellar Projection Mediates Ibogaine-Induced Degeneration of Purkinje Cells: A Model of Indirect, Trans-Synaptic Excitotoxicity [PDF]

, 1997
Elizabeth O’Hearn, Mark E. Molliver
openalex   +1 more source

Does Lithium Lower the Risk of Glaucoma—A Danish Nationwide Study

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background Glaucoma is an optic neuropathy caused by neurodegenerative loss of retinal ganglion cells (RGC). Mechanisms that contribute to RGC death include some of the same mechanisms involved in bipolar disorders (BD) and are the same mechanisms which are targeted by lithium (Li).
Tomas Hajek, Orestes Forlenza, Marcelo Nicolela, Ann‐Eva Christensen, Henrik Vorum, René Ernst Nielsen   +5 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity [PDF]

, 1995
JR Brorson, PA Manzolillo, Simon J. Gibbons, RJ Miller   +3 more
openalex   +1 more source

CCR5 predicts neurotoxicity in CAR‐T‐cell therapy

British Journal of Haematology, EarlyView.
Patients undergoing chimeric antigen receptor T (CAR T)‐cell therapy are at risk of developing immune effector cell‐associated neurotoxicity syndrome (ICANS). We observed an upregulation of CCR5 and CCR2 expression in CD4+ T cells among patients who developed ICANS.
Ayal Rozenberg, Shahar Shelly, Raz Winer, Riva Fineman, Shani Haller, Shimrit Ringelstein‐Harlev, Israel Henig, Dana Yehudai‐Ofir, Tsila Zuckerman, Tamar Tadmor, Reut Harel, Esther Ganelin‐Cohen, Ofrat Beyar‐Katz   +12 more
wiley   +1 more source

Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field [PDF]

, 1999
David Virley, R.M. Ridley, J.D. Sinden, T. R. Kershaw, Spencer P. Harland, Tahira Rashid, Sarah French, Peter Sowinski, Jeffrey A. Gray, P. L. Lantos, Helen Hodges   +10 more
openalex   +1 more source

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Neuronal Death and Blood–Brain Barrier Breakdown after Excitotoxic Injury Are Independent Processes [PDF]

, 1999
Zu‐Lin Chen, Justin A. Indyk, Thomas Bugge, Keith W. Kombrinck, Jay L. Degen, Sidney Strickland   +5 more
openalex   +1 more source

Associations of glycaemia‐related risk factors with dementia and cognitive decline in individuals with type 2 diabetes: A systematic review and meta‐analysis

Diabetic Medicine, EarlyView.
Abstract Aims To quantify prospective associations of glycaemia‐related factors with cognitive decline and all‐cause dementia and its subtypes in people with type 2 diabetes. Methods We systematically searched Embase and MEDLINE (January 2000–October 2024) for studies in people with diabetes reporting longitudinal associations of a relevant exposure (i.
Mahtab Tabesh, Julian W. Sacre, Kanika Mehta, Lei Chen, Seyedeh Forough Sajjadi, Dianna J. Magliano, Jonathan E. Shaw   +6 more
wiley   +1 more source

The bile acid chenodeoxycholic acid associates with reduced stroke in humans and mice

Journal of Lipid Research
Bile acids are liver-derived signaling molecules that can be found in the brain, but their role there remains largely unknown. We found increased brain chenodeoxycholic acid (CDCA) in mice with absent 12α-hydroxylase (Cyp8b1), a bile acid synthesis ...
Vera F. Monteiro-Cardoso, Xin Yi Yeo, Han-Gyu Bae, David Castano Mayan, Mariam Wehbe, Sejin Lee, Kumar Krishna-K, Seung Hyun Baek, Leon F. Palomera, Lik Hang Wu, Leroy S. Pakkiri, Sangeetha Shanmugam, Kai Ping Sem, Mun Geok Yew, Matthew P. Parsons, Michael R. Hayden, Leonard L.L. Yeo, Vijay K. Sharma, Chester Drum, Elisa A. Liehn, Sreedharan Sajikumar, Svend Davanger, Dong-Gyu Jo, Mark Y.Y. Chan, Benjamin Y.Q. Tan, Sangyong Jung, Roshni R. Singaraja   +26 more
doaj   +1 more source