Results 91 to 100 of about 90,697 (359)

The Possible Role of Metformin and Fibroblast Growth Factor-21 in Multiple Sclerosis Neuropathology: Birds of a Feather Flock Together. [PDF]

Eur J Neurosci
Predisposing factors of multiple sclerosis and Role of Metformin and Fibroblast Growth Factor‐21: A key predisposing factor for multiple sclerosis (MS) is genetic susceptibility, which is associated with an increased risk of the disease. Environmental factors, such as low vitamin D levels, smoking, and viral infections, also contribute to the ...
Abulaban AA, Al-Kuraishy HM, Al-Gareeb AI, Ahmed EA, Alruwaili M, Alexiou A, Papadakis M, El-Saber Batiha G.   +7 more
europepmc   +2 more sources

Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity‐induced axonal degeneration

The FASEB Journal, 2017
NAD+ depletion is a common phenomenon in neurodegenerative pathologies. Excitotoxicity occurs in multiple neurologic disorders and NAD+ was shown to prevent neuronal degeneration in this process through mechanisms that remained to be determined.
P. Vaur, B. Brugg, M. Mericskay, Zhenlin Li, Mark S. Schmidt, D. Vivien, C. Orset, E. Jacotot, C. Brenner, Eric Duplus   +9 more
semanticscholar   +1 more source

A Proteomics Profiling Reveals the Neuroprotective Effects of Melatonin on Exogenous β‐amyloid‐42 Induced Mitochondrial Impairment, Intracellular β‐amyloid Accumulation and Tau Hyperphosphorylation in Human SH‐SY5Y Cells

Cell Biology International, EarlyView.
ABSTRACT Alzheimer's disease (AD) is prevalent in the elderly population and characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), composed of tau proteins, and extracellular deposition of beta‐amyloid protein (Aβ). The present study aimed to investigate the neuroprotective effects of melatonin on Aβ42‐induced AD‐like ...
Jiraporn Panmanee, Matthew Phanchana, Phorutai Pearngam, Nopphon Petchyam, Kornkanok Promthep, Ponlawit Wisomka, Suchanoot Kutpruek, Supitcha Pannengpetch, Tanya Prasertporn, Sujira Mukda, Piyarat Govitrapong, Chutikorn Nopparat   +11 more
wiley   +1 more source

Methylxanthines, Seizures, and Excitotoxicity [PDF]

, 2010
Clinical evidence, in particular the wide use of theophylline as a bronchodilator, suggests that methylxanthines can cause seizures in patients without known underlying epilepsy. Theophylline is also known to be an added risk factor for seizure exacerbation in patients with epilepsy.
openaire   +3 more sources

Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

Molecular Neurodegeneration, 2017
Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and related signaling pathways.
T. Miyamoto, L. Stein, Reuben Thomas, Biljana Djukic, Praveen Taneja, Joseph A. Knox, Keith A. Vossel, L. Mucke   +7 more
semanticscholar   +1 more source

Selective vulnerability to kainate-induced oxidative damage in different rat brain regions [PDF]

Journal of Applied Toxicology 21(5): 403-407 (2001), 2007
Some markers of oxidative injury were measured in different rat brain areas (hippocampus, cerebral cortex, striatum, hypothalamus, amygdala/piriform cortex and cerebellum) after the systemic administration of an excitotoxic dose of kainic acid (KA, 9 mg kg(-1) i.p.) at two different sampling times (24 and 48 h).
arxiv  

Mechanisms of Neuronal Protection against Excitotoxicity, Endoplasmic Reticulum Stress, and Mitochondrial Dysfunction in Stroke and Neurodegenerative Diseases

Oxidative Medicine and Cellular Longevity, 2015
In stroke and neurodegenerative disease, neuronal excitotoxicity, caused by increased extracellular glutamate levels, is known to result in calcium overload and mitochondrial dysfunction.
H. Prentice, J. Modi, Jang-Yen Wu
semanticscholar   +1 more source

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides

Frontiers in Cellular Neuroscience, 2015
The microtubule-associated axonal specification collapsin response mediator protein 2 (CRMP2) is a novel target for neuroprotection. A CRMP2 peptide (TAT-CBD3) conjugated to the HIV transactivator of transcription (TAT) protein’s cationic cell ...
Aubin eMoutal, Liberty eFrancois-Moutal, Joel M Brittain, May eKhanna, Rajesh eKhanna   +4 more
doaj   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen, Dehghani, Faramarz, Ehrlich, Angela, Geisslinger, Gerd, Hobusch, Constance, Kallendrusch, Sonja, Koch, Marco, Nowicki, Marcin, Ziebell, Simone   +8 more
core   +3 more sources

Exploring biomarkers of neurodegeneration in epilepsy: Critical insights

Epileptic Disorders, EarlyView.
Abstract The advent of biofluid biomarkers for neurodegenerative disorders has precipitated a surge in recent evidence regarding their role in epilepsy. In this literature review, we examine the diagnostic, prognostic, and therapeutic potential of several biomarkers, including amyloid‐beta (Aβ) protein, total (t‐tau), phosphorylated tau (p‐tau) protein,
Rida Farhan, Syeda Amrah Hashmi, Jaideep Kapur, Anelyssa D'Abreu, Vineet Punia, Carol Manning, Vanessa L. Smith, Ifrah Zawar   +7 more
wiley   +1 more source