Results 101 to 110 of about 95,867 (358)

Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity

Mediators of Inflammation, 2014
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system.
G. Olmos, J. Lladó
semanticscholar   +1 more source

TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

Frontiers in Molecular Neuroscience, 2019
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzheimer’s disease (AD), which may compromise the function of BDNF upon neuronal activity and survival.
João Fonseca-Gomes, João Fonseca-Gomes, André Jerónimo-Santos, André Jerónimo-Santos, Angelina Lesnikova, Plinio Casarotto, Eero Castrén, Ana M. Sebastião, Ana M. Sebastião, Maria J. Diógenes, Maria J. Diógenes   +10 more
doaj   +1 more source

Molecular mechanisms of ischemia and glutamate excitotoxicity.

Life Science, 2023
Diogo Neves, Ivan L. Salazar, Ramiro D. Almeida, Raquel M. Silva   +3 more
semanticscholar   +1 more source

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

Journal of Neuroscience, 1992
In Alzheimer's disease (AD), abnormal accumulations of beta-amyloid are present in the brain and degenerating neurons exhibit cytoskeletal aberrations (neurofibrillary tangles).
M. Mattson, B. Cheng, D. Davis, K. Bryant, I. Lieberburg, R. Rydel   +5 more
semanticscholar   +1 more source

Preterm Hypoxic Ischemic Encephalopathy

Frontiers in Pediatrics, 2016
Hypoxic ischemic encephalopathy (HIE) is a recognizable and defined clinical syndrome in term infants that results from a severe or prolonged hypoxic ischemic episode before or during birth.
Krishna G Gopagondanahalli, Jingang Li, Michael Fahey, Rod W Hunt, Graham Jenkin, Suzanne Lee Miller, Atul Malhotra   +6 more
doaj   +1 more source

Proteomic analysis of cortical neuronal cultures treated with poly-arginine peptide-18 (R18) and exposed to glutamic acid excitotoxicity [PDF]

, 2019
Poly-arginine peptide-18 (R18) has recently emerged as a highly effective neuroprotective agent in experimental stroke models, and is particularly efficacious in protecting cortical neurons against glutamic acid excitotoxicity.
Anderton, Ryan S, Knuckey, Neville W, MacDougall, Gabriella, Mastaglia, Frank L, Meloni, Bruno P   +4 more
core   +1 more source

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio, Reilly, James, Shu, Xinhua, Tiano, Luca, Tohari, Ali Mohammad, Zhang, Xun, Zhou, Xinzhi   +6 more
core   +1 more source

Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022
Zihuan Shen, M. Xiang, Chen Chen, Fan Ding, Yuling Wang, Chang Shang, Laiyun Xin, Yang Zhang, Xiangning Cui   +8 more
semanticscholar   +1 more source

Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation

PLoS ONE, 2017
Prolactin (PRL) is a peptidic hormone that displays pleiotropic functions in the organism including different actions in the brain. PRL exerts a neuroprotective effect against excitotoxicity produced by glutamate (Glu) or kainic acid in both in vitro and
N. A. Rivero-Segura, E. Flores-Soto, Selene García de la Cadena, I. Coronado-Mares, J. C. Gómez-Verjan, Diana G. Ferreira, E. A. Cabrera-Reyes, Luísa V. Lopes, L. Massieu, M. Cerbón   +9 more
semanticscholar   +1 more source

Efficacy and tolerability of perampanel as add‐on therapy in Dravet syndrome: A prospective real‐world study

Epilepsia Open, EarlyView.
Abstract Objective To investigate the efficacy and tolerability of perampanel (PER) on Dravet syndrome in China by a prospective real‐world study. Methods We prospectively enrolled children with Dravet syndrome from the neurology clinic of Shenzhen Children's Hospital from September 2020 to October 2021.
Han Wang, Hong Chen, Xin Ding, Xueyan Cao, Jiahui Mai, Huafang Zou, Dongfang Zou, Yanwei Zhu, Jianxiang Liao, Dezhi Cao   +9 more
wiley   +1 more source