Results 101 to 110 of about 46,919 (266)

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source

Monosodium Glutamate Treatment Elevates the Immunoreactivity of GFAP and S100β in Caudate Nucleus of the Striatum in Rats

Biomedicines
Background Monosodium glutamate (MSG) in its anionic form, glutamate, is one of the main excitatory amino acids. Excess of this neurotransmitter may lead to excitotoxicity affecting neurons and astrocytes responsible for glutamate metabolism in different
Karol Rycerz, Aleksandra Krawczyk, Jadwiga Jaworska-Adamu, Marcin B. Arciszewski   +3 more
doaj   +1 more source

Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus

Epilepsia, EarlyView.
Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
AnnaLin M. Woo, Erik J. Fleischel, Dipan C. Patel, Harald Sontheimer   +3 more
wiley   +1 more source

Effects of Calcium Ion Dyshomeostasis and Calcium Ion-Induced Excitotoxicity in Parkinson’s Disease

Journal of Molecular Pathology
Calcium ions (Ca2+) are vital intracellular messengers that regulate a multitude of neuronal functions, including synaptic transmission, plasticity, exocytosis, and cell survival.
Daleum Nam, Hyejung Kim, Sun Jung Han, Ilhong Son, Dong Hwan Ho   +4 more
doaj   +1 more source

WONOEP XVII appraisal: Targeting network excitability beyond the synapse ‐Neurotransmitter, ionic, and electro ‐diffusions

Epilepsia, EarlyView.
Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire, Marco de Curtis, Jeffrey Noebels, Gilles Huberfeld, Piotr Suffczynski, Vadym Gnatkovsky, Olga Tyurikova, Dominique Durand, David C. Henshall, Cian McCafferty   +9 more
wiley   +1 more source

Excitotoxicity, Synaptic Repair, and Functional Recovery in the Mammalian Cochlea: A Review of Recent Findings [PDF]

, 1999
Rémy Pujol, Jean‐Luc Puel
openalex   +1 more source

Excitotoxicity in Perinatal Brain Injury

Brain Pathology, 2005
Excitotoxicity is an important mechanism involved in perinatal brain injuries. Glutamate is the major excitatory neurotransmitter, and most neurons as well as many oligodendrocytes and astrocytes possess receptors for glutamate. Perinatal insults such as hypoxia‐ischemia, stroke, hypoglycemia, kernicterus, and trauma can disrupt synaptic function ...
openaire   +3 more sources

Topiramate for the treatment of neonatal seizures and beyond

Epilepsia, EarlyView.
Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley   +1 more source

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo [PDF]

, 1995
Jörg B. Schulz, RT Matthews, BG Jenkins, RJ Ferrante, Donald Siwek, DR Henshaw, P. Ben Cipolloni, Patrizia Mecocci, NW Kowall, BR Rosen   +9 more
openalex   +1 more source

d‐amino acids: new functional insights

The FEBS Journal, EarlyView.
This review explores recent advances in understanding d‐amino acids (d‐AAs) and their pivotal roles across organisms, from plants to humans. d‐AAs have been implicated in key physiological processes, including cancer, inflammation, immune regulation, kidney disease, diabetes, and nervous system function.
Loredano Pollegioni, Natasa Kustrimovic, Luciano Piubelli, Elena Rosini, Valentina Rabattoni, Silvia Sacchi   +5 more
wiley   +1 more source