Results 111 to 120 of about 90,697 (359)
Frontiers in Neuroscience, 2018 Axon degeneration has been implicated as a pathological process in several neurodegenerative diseases and acquired forms of neural injury. We have previously shown that stabilizing microtubules can protect axons against excitotoxin-induced fragmentation,
Kelsey Hanson +3 more
doaj +1 more source
Neuroprotection by MKK7 inhibition in excitotoxicity [PDF]
SpringerPlus, 2015 Excitotoxicity following cerebral ischemia elicits a molecular cascade, which leads neurons to death. One key molecule of this pathway is c-Jun-N-terminal kinase (JNK), a MAP kinase, which plays both physiological and pathological roles in neurons. We have previously shown that JNK blockade by specific cell permeable peptide inhibitors significantly ...
Noemi Tonna +14 more
openaire +2 more sources
Tumor Necrosis Factor Alpha: A Link between Neuroinflammation and Excitotoxicity
Mediators of Inflammation, 2014 Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine that exerts both homeostatic and pathophysiological roles in the central nervous system.
G. Olmos, J. Lladó
semanticscholar +1 more source
Epilepsia Open, EarlyView.Abstract Objective Posttraumatic epilepsy (PTE) and cognitive impairment are severe complications following traumatic brain injury (TBI). Neuroinflammation likely contributes, but the role of specific inflammatory mediators requires clarification. High‐mobility group box 1 (HMGB1) is an inflammatory cytokine released after brain injury that may be ...
Irma Wati Ngadimon +12 more
wiley +1 more source
Phase I and Phase II Therapies for Acute Ischemic Stroke: An Update on Currently Studied Drugs in Clinical Research. [PDF]
, 2017 Acute ischemic stroke is a devastating cause of death and disability, consequences of which depend on the time from ischemia onset to treatment, the affected brain region, and its size.
Akyol, Onat +6 more
core +3 more sources
Intrinsic brain network stability during kainic acid‐induced epileptogenesis
Epilepsia Open, EarlyView.Abstract Objective Altered intrinsic brain networks have been revealed in patients with epilepsy and are strongly associated with network reorganization in the latent period. However, the development and reliability of intrinsic brain networks in the early period of epileptogenesis are not well understood.
Nastaran Jafari +8 more
wiley +1 more source
Molecular mechanisms of ischemia and glutamate excitotoxicity.
Life Science, 2023 Diogo Neves +3 more
semanticscholar +1 more source
PLoS ONE, 2017 Prolactin (PRL) is a peptidic hormone that displays pleiotropic functions in the organism including different actions in the brain. PRL exerts a neuroprotective effect against excitotoxicity produced by glutamate (Glu) or kainic acid in both in vitro and
N. A. Rivero-Segura +9 more
semanticscholar +1 more source
Vesicular glutamatergic transmission in noise-induced loss and repair of cochlear ribbon synapses [PDF]
, 2019 Noise-induced excitotoxicity is thought to depend on glutamate. However, the excitotoxic mechanisms are unknown, and the necessity of glutamate for synapse loss or regeneration is unclear. Despite absence of glutamatergic transmission from cochlear inner
Carlquist, Jason +12 more
core +1 more source
Statins' protective effects on focal epilepsy are independent of LDL‐C
Epilepsia Open, EarlyView.Abstract Objective This study evaluates the potential protective effects of statins against epilepsy, focusing on their differential impacts on focal and generalized epilepsy. It investigates the role of statins through the HMGCR gene and associated low‐density lipoprotein (LDL) cholesterol levels.
Zhen Sun +6 more
wiley +1 more source