Results 111 to 120 of about 82,251 (326)
Metabolic dysfunction in the brain: implications of astrocyte activation
Frontiers in Cellular Neuroscience, 2015 Astrocytes are the most abundant cells in the central nervous system (CNS). They participate in different processes such as maintaining the blood–brain barrier and ion homeostasis, uptake and turnover of neurotransmitters, and formation of synapses.
Sonia Luz Albarracin
doaj +1 more source
Neuroprotection, EarlyView.Abstract Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential, but its role in POD pathogenesis remains unclear.
Zhiming Dai +3 more
wiley +1 more source
Phospho-dependent Accumulation of GABABRs at Presynaptic Terminals after NMDAR Activation
Cell Reports, 2016 Here, we uncover a mechanism for regulating the number of active presynaptic GABAB receptors (GABABRs) at nerve terminals, an important determinant of neurotransmitter release.
Saad Hannan +3 more
doaj +1 more source
Exploiting glial cell functions for neurodegeneration therapy
Neuroprotection, EarlyView.The figure illustrates the potential of targeting glial cell functions and their interactions with neurons as a therapeutic strategy for neurodegeneration. Abstract Glial cells, alongside neurons, are the major cells of the central nervous system.
Tobiloba S. Olajide
wiley +1 more source
Huntington's Disease and Striatal Signaling
Frontiers in Neuroanatomy, 2011 Huntington’s Disease (HD) is the most frequent neurodegenerative disease caused by an expansion of polyglutamines (CAG). The main clinical manifestations of HD are chorea, cognitive impairment and psychiatric disorders.
Emmanuel eRoze +7 more
doaj +1 more source
Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery +43 more
wiley +1 more source
The Role of Canonical Transient Receptor Potential Channels in Seizure and Excitotoxicity
Cells, 2014 Canonical transient receptor potential (TRPC) channels are a family of polymodal cation channels with some degree of Ca2+ permeability. Although initially thought to be channels mediating store-operated Ca2+ influx, TRPC channels can be activated by ...
Fang Zheng, Kevin D. Phelan
doaj +1 more source
Mechanism of Ammonia‐Induced Brain Damage in Chinese Striped‐Necked Turtle (Mauremys sinensis)
Integrative Zoology, EarlyView.High levels of ammonia disrupt the integrity of the brain barrier in Mauremys sinensis, leading to tissue edema. This, in turn, triggers a series of cascade reactions, including disturbances in neurotransmitter levels, particularly glutamate, which might further exacerbate the neurotoxic effects.
Yunjuan Xiao +6 more
wiley +1 more source
Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity [PDF]
, 2012 Shamsudheen Moidunny +8 more
openalex +1 more source
Integrative Zoology, EarlyView.Prenatal hypoxia enhances adult hypoxia tolerance in Brandt's voles, preserving cognitive and memory functions. Transcriptomic analysis reveals adaptive changes in energy metabolism, oxygen transport, and neuroprotective mechanisms, highlighting developmental plasticity.
Mengyang Li +5 more
wiley +1 more source