Results 121 to 130 of about 90,697 (359)
Targeting cholesterol homeostasis to fight hearing loss: a new perspective
Frontiers in Aging Neuroscience, 2015 Sensorineural hearing loss (SNHL) is a major pathology of the inner ear that affects nearly 600 million people worldwide. Despite intensive researches, this major health problem remains without satisfactory solutions.
Brigitte eMalgrange +3 more
doaj +1 more source
Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022 Zihuan Shen +8 more
semanticscholar +1 more source
Disruption of nNOS-NOS1AP protein-protein interactions suppresses neuropathic pain in mice [PDF]
, 2018 Elevated N-methyl-D-aspartate receptor (NMDAR) activity is linked to central sensitization and chronic pain. However, NMDAR antagonists display limited therapeutic potential because of their adverse side effects. Novel approaches targeting the NR2B-PSD95-
Chawla, Aarti +6 more
core +1 more source
Exploration, EarlyView.Targeting mitochondrial dysfunction presents a potential therapeutic approach for treating spinal cord injury. We have successfully designed and synthesized a functional Se@NADH nanodrug system. This system offers neuroprotective and neuroregenerative benefits by modulating mitochondrial function and neutralizing reactive oxygen species, thereby ...
Guibin Gao +12 more
wiley +1 more source
Molecular Neurodegeneration, 2011 Astrocytes are fundamental for brain homeostasis and the progression and outcome of many neuropathologies including Alzheimer's disease (AD). In the triple transgenic mouse model of AD (3xTg-AD) generalised hippocampal astroglia atrophy precedes a ...
Verkhratsky Alexei +3 more
doaj +1 more source
Mitochondria and neuronal glutamate excitotoxicity
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998 The role of mitochondria in the control of glutamate excitotoxicity is investigated. The response of cultured cerebellar granule cells to continuous glutamate exposure is characterised by a transient elevation in cytoplasmic free calcium concentration followed by decay to a plateau as NMDA receptors partially inactivate. After a variable latent period,
David G. Nicholls, Samantha L. Budd
openaire +2 more sources
Ketamine: A Neuroanesthesiologist's Friend or Foe?
Journal of Neuroanaesthesiology and Critical Care, 2018 Ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, introduced into clinical practice six decades ago, has often been the worst fear of a neuroanesthesiologist due to its concerns of causing a rise in intracranial pressure and increasing ...
Ankur Luthra, Girija Prasad Rath
doaj +1 more source
Frontiers in Cellular Neuroscience, 2016 Glutamate-induced excitotoxicity is a major contributor to motor neuron degeneration in the pathogenesis of amyotrophic lateral sclerosis (ALS). The spinal cord × Neuroblastoma hybrid cell line (NSC-34) is often used as a bona fide cellular model to ...
B. Madji Hounoum +11 more
semanticscholar +1 more source
Omega-3 Fatty Acids Improve Recovery, whereas Omega-6 Fatty Acids Worsen Outcome, after Spinal Cord Injury in the Adult Rat [PDF]
, 2006 Spinal cord injury (SCI) is a cause of major neurological disability, and no satisfactory treatment is currently available. Evidence suggests that polyunsaturated fatty acids (PUFAs) could target some of the pathological mechanisms that underlie damage ...
Curran, O. E. +5 more
core +1 more source
Journal of Neurochemistry, 2016 In multiple sclerosis (MS), a candidate downstream mechanism for neuronal injury is glutamate (Glu)‐induced excitotoxicity, leading to toxic increases in intraneuronal Ca2+.
D. Luchtman +6 more
semanticscholar +1 more source