Results 121 to 130 of about 95,867 (358)
Frontiers in Cellular Neuroscience, 2016 Glutamate-induced excitotoxicity is a major contributor to motor neuron degeneration in the pathogenesis of amyotrophic lateral sclerosis (ALS). The spinal cord × Neuroblastoma hybrid cell line (NSC-34) is often used as a bona fide cellular model to ...
B. Madji Hounoum +11 more
semanticscholar +1 more source
Glia, EarlyView.Spatial transcriptomic analysis unravels the mechanisms by which HDACi ameliorates neuroinflammation and enhances neuroprotection by modulating the expression of microglial transcriptomes in the ischemic mouse brain. ABSTRACT Ischemic stroke significantly contributes to global morbidity and disability through a cascade of neurological responses ...
Kevin Jayaraj +5 more
wiley +1 more source
Frontiers in Neurology, 2018 Overexposure of the glutamatergic N-methyl-d-aspartate (NMDA) receptor to the excitatory neurotransmitter l-glutamic acid leads to neuronal cell death by excitotoxicity as a result of increased intracellular Ca2+, mitochondrial dysfunction, and apoptosis.
Ibram Amin Fouad +3 more
doaj +1 more source
Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley +1 more source
Neural Regeneration Research, 2016 Excitotoxicity is a process observed in many disease states by which an excessive synaptic excitation causes neuronal death, and is thought to be triggered by the extracellular accumulation of the excitatory neurotransmitter glutamate, which binds and ...
V. Li, Y. T. Wang
semanticscholar +1 more source
Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration
Cell Reports, 2019 Summary: Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. In this study, we provide in vivo evidence that this spatial specificity is lost in Shiverer (Shi) mice, a model for progressive ...
Dinesh C. Joshi +8 more
doaj
Frontiers in Neuroscience, 2018 Glutamate-induced excitotoxicity is one of the main causes of neuronal cell death in stroke. Compound 22a has been previously reported as a promising neuroprotective compound derived from tetramethylpyrazine, which is a widely used active ingredient of ...
Haiyun Chen +9 more
doaj +1 more source
Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]
, 2015 The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core +1 more source
Research progress of neurovascular units involved in ischemic stroke
Ibrain, EarlyView.The brain receives less blood when an ischemic stroke develops, which damages neurons and leads to an increased release of Pro‐inflammatory mediators that activate neurovascular unit (NVU). When the tight junctions are broken and the basement membrane is disrupted by matrix metalloproteinases produced by active endothelial and pericellular cells ...
Yu Yang +4 more
wiley +1 more source