Supplementary Figure 6 from Oncogene <i>AEG-1</i> Promotes Glioma-Induced Neurodegeneration by Increasing Glutamate Excitotoxicity [PDF]
, 2023 Seok‐Geun Lee +14 more
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APP Induces AICD‐Mediated Autophagy‐Dependent Axon Degeneration
Aging Cell, EarlyView.In the adult Drosophila wing, amyloid precursor protein (APP) promotes axon degeneration through its intracellular domain (AICD) via an autophagy‐dependent pathway. The transcription factor dFoxO is essential for APP/AICD‐induced autophagy and plays a critical role in mediating the resulting neurodegeneration.
Jingjing Luo +12 more
wiley +1 more source
The NMDA Receptor Antagonist Memantine Modulates Aging and Stress Resilience
Aging Cell, EarlyView.Memantine, an NMDA receptor antagonist, extends lifespan and enhances stress resilience in C. elegans through caloric restriction–like metabolic adaptations, including reduced oxidative stress and increased fatty acid β‐oxidation, revealing a conserved mechanism linking glutamatergic signaling to healthy aging.
Vaida Juozaityte +8 more
wiley +1 more source
GENE EXPRESSION FOLLOWING TRAUMATIC BRAIN INJURY [PDF]
, 1998 The pathology which results from traumatic brain injury (TBI) have long been believed to be immediate and irreversible. However, recently it has been shown that, although the primary effects are virtually unavoidable, the secondary effects manifest ...
Malhotra, Rajiv
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Transglutaminase is a Therapeutic Target for Oxidative Stress, Excitotoxicity and Stroke: A new Epigenetic Kid on the Cns Block [PDF]
, 2013 Manuela Basso, Rajiv R. Ratan
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Anaesthesia, EarlyView.Summary Introduction The certainty of the effectiveness of interventions to manage postoperative neurocognitive complications remains unclear. The objective of this umbrella review was to synthesise and evaluate the evidence for interventions aimed at reducing the incidence of peri‐operative neurocognitive complications.
Filippo D'Amico +7 more
wiley +1 more source
Chronic Nicotine Selectively Enhances α4β2* Nicotinic Acetylcholine Receptors in the Nigrostriatal Dopamine Pathway [PDF]
, 2009 These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional α4β2* nAChRs in the nigrostriatal dopaminergic (DA) pathway.
Cai, Haijiang +5 more
core
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
Excitotoxic Lesions of the Amygdala Fail to Produce Impairment in Visual Learning for Auditory Secondary Reinforcement But Interfere with Reinforcer Devaluation Effects in Rhesus Monkeys [PDF]
, 1997 Ludiše Málková +2 more
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A complex network perspective on brain disease
Biological Reviews, EarlyView.ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley +1 more source