Results 131 to 140 of about 46,919 (266)
Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications
Experimental Physiology, EarlyView.Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó +1 more
wiley +1 more source
Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells [PDF]
, 2000 Manus W. Ward +3 more
openalex +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Experimentally induced status epilepticus induces microglial TNFα release, which binds to astrocytic TNFR1 and triggers activation of RIPK1/RIPK3/MLKL signalling, initiating necroptotic astrocytic death that contributes to the development of hippocampal sclerosis. Created with Biorender.com.
Zhou Wu +3 more
wiley +1 more source
Correlation of CGS 19755 Neuroprotection against in vitro Excitotoxicity and Focal Cerebral Ischemia
, 1995 Miguel A. Pérez‐Pinzón +5 more
openalex +1 more source
NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase [PDF]
, 2000 Allen S. Mandir +9 more
openalex +1 more source
Adaptations to hypoxia in the vertebrate retina
The Journal of Physiology, EarlyView.Abstract figure legend Most animals, including mammals, are susceptible to the damaging effects of hypoxia or ischaemia, where the result is neuronal cell death in the brain. By contrast, some neurons of the mammalian retina are less sensitive to hypoxia. In both brain and retina, neurons may survive if first preconditioned with ischaemia.
Michael G. Jonz
wiley +1 more source
ω-Agatoxin IVA and excitotoxicity in cortical neuronal cultures
, 1996 Heather S. Lustig +2 more
openalex +1 more source
STAT3 and NFκB Activation Precedes Glial Reactivity in the Excitotoxically Injured Young Cortex but not in the Corresponding Distal Thalamic Nuclei [PDF]
, 2000 Laia Acarín +2 more
openalex +1 more source
Astrocytes: Orchestrators of brain gas exchange and oxygen homeostasis
The Journal of Physiology, EarlyView.Abstract figure legend Oxygen and carbon dioxide enter the body via breathing; in the brain astrocytes play a key role balancing oxygen delivery with carbon dioxide removal. Abstract If we consider neurons like muscles during exercise, the demand for oxygen (O2) and carbon dioxide (CO2) elimination is constantly changing.
Isabel N. Christie
wiley +1 more source