Results 131 to 140 of about 95,867 (358)
White Matter Loss in a Mouse Model of Periventricular Leukomalacia Is Rescued by Trophic Factors
Brain Sciences, 2013 Periventricular leukomalacia (PVL) is the most frequent cause of cerebral palsy and other intellectual disabilities, and currently there is no treatment.
Pierre Gressens +13 more
doaj +1 more source
Ibrain, EarlyView.Polysaccharide‐based nanoparticles offer versatile platforms for drug delivery and immune modulation in neurodegenerative diseases. This review highlights their potential in treating Alzheimer's, Parkinson's, and multiple sclerosis, focusing on targeted delivery and neuroinflammation.
Leto‐Aikaterini Tziveleka +5 more
wiley +1 more source
Journal of Pharmacological Sciences, 2009 .: We have previously demonstrated an important role of influx of Cl− rather than Ca2+ in acute excitotoxicity in adult rat retina. As p53 has been implicated in delayed apoptotic cell death, here we examined the appearance of p53 immunoreactivity in a ...
Yasuhiro Hama +4 more
doaj
Targeting cholesterol homeostasis to fight hearing loss: a new perspective
Frontiers in Aging Neuroscience, 2015 Sensorineural hearing loss (SNHL) is a major pathology of the inner ear that affects nearly 600 million people worldwide. Despite intensive researches, this major health problem remains without satisfactory solutions.
Brigitte eMalgrange +3 more
doaj +1 more source
l-Lactate-Mediated Neuroprotection against Glutamate-Induced Excitotoxicity Requires ARALAR/AGC1
Journal of Neuroscience, 2016 ARALAR/AGC1/Slc25a12, the aspartate-glutamate carrier from brain mitochondria, is the regulatory step in the malate-aspartate NADH shuttle, MAS. MAS is used to oxidize cytosolic NADH in mitochondria, a process required to maintain oxidative glucose ...
Irene Llorente‐Folch +4 more
semanticscholar +1 more source
iMetaOmics, EarlyView.This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu +8 more
wiley +1 more source
Changes in intracellular pH associated with glutamate excitotoxicity [PDF]
, 1993 Zachary Hartley, JM Dubinsky
openalex +1 more source
Obesity as a Risk Factor for Alzheimer’s Disease: Implication of Leptin and Glutamate
Frontiers in Neuroscience, 2019 Obesity is known to induce leptin and insulin resistance. Leptin is a peptide hormone synthesized in adipose tissue that mainly regulates food intake.
Ana Lloret +4 more
doaj +1 more source
Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity
Molecular Pain, 2017 N-methyl-D-aspartate (NMDA) receptor overactivation is involved in neuronal damage after stroke. However, the mechanism underlying NMDA receptor-mediated excitotoxicity remains unclear.
Yu Wu +4 more
semanticscholar +1 more source
Pregabalin Attenuates Excitotoxicity in Diabetes
PLoS ONE, 2013 Diabetes can exacerbate seizures and worsen seizure-related brain damage. In the present study, we aimed to determine whether the standard antiepileptic drug pregabalin (PGB) protects against pilocarpine-induced seizures and excitotoxicity in diabetes. Adult male Sprague-Dawley rats were divided into either a streptozotocin (STZ)-induced diabetes group
Sheng Nan Wu +5 more
openaire +5 more sources