Results 141 to 150 of about 90,697 (359)

l-Lactate-Mediated Neuroprotection against Glutamate-Induced Excitotoxicity Requires ARALAR/AGC1

Journal of Neuroscience, 2016
ARALAR/AGC1/Slc25a12, the aspartate-glutamate carrier from brain mitochondria, is the regulatory step in the malate-aspartate NADH shuttle, MAS. MAS is used to oxidize cytosolic NADH in mitochondria, a process required to maintain oxidative glucose ...
Irene Llorente‐Folch, C. Rueda, Irene Pérez-Liébana, J. Satrústegui, B. Pardo   +4 more
semanticscholar   +1 more source

NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders

Pharmaceuticals
Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by progressive neuronal loss, leading to cognitive, motor, and behavioral impairments.
Ayodeji Olatunde Egunlusi, Jacques Joubert   +1 more
doaj   +1 more source

Preterm Hypoxic Ischemic Encephalopathy

Frontiers in Pediatrics, 2016
Hypoxic ischemic encephalopathy (HIE) is a recognizable and defined clinical syndrome in term infants that results from a severe or prolonged hypoxic ischemic episode before or during birth.
Krishna G Gopagondanahalli, Jingang Li, Michael Fahey, Rod W Hunt, Graham Jenkin, Suzanne Lee Miller, Atul Malhotra   +6 more
doaj   +1 more source

Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity

Molecular Pain, 2017
N-methyl-D-aspartate (NMDA) receptor overactivation is involved in neuronal damage after stroke. However, the mechanism underlying NMDA receptor-mediated excitotoxicity remains unclear.
Yu Wu, Changwan Chen, Qian Yang, Mingfei Jiao, Shuang Qiu   +4 more
semanticscholar   +1 more source

Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity [PDF]

, 2015
Background: Excitotoxicity (the toxic overstimulation of neurons by the excitatory transmitter Glutamate) is a central process in widespread neurodegenerative conditions such as brain ischemia and chronic neurological diseases.
Ahmed, Towfiq, Amjad, Uzair, An, JunHyung, Asemota, Daniel, Del Rosario, John S, Feldmann, Katherine Genevieve, Ko, BakKeung, Mahmud, Tauhid, Mano, Itzhak, Mei, Shirley, Salama, Maha   +10 more
core   +2 more sources

Optimized Long‐TE 1H sLASER MR Spectroscopic Imaging at 3T for Separate Quantification of Glutamate and Glutamine in Glioma

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Glutamate and glutamine are critical metabolites in gliomas, each serving distinct roles in tumor biology. Separate quantification of these metabolites using in vivo MR spectroscopy (MRS) at clinical field strengths (≤ 3T) is hindered by their molecular similarity, resulting in overlapping, hence indistinguishable, spectral peaks ...
Seyma Alcicek, Michael W. Ronellenfitsch, Joachim P. Steinbach, Andrei Manzhurtsev, Dennis C. Thomas, Katharina J. Weber, Vincent Prinz, Marie‐Thérèse Forster, Elke Hattingen, Ulrich Pilatus, Katharina J. Wenger   +10 more
wiley   +1 more source

Glaucoma: Current and New Therapeutic Approaches

Biomedicines
Glaucoma is identified by the loss of retinal ganglion cells (RGCs). The primary approach to managing glaucoma is to control intraocular pressure (IOP).
Hsin-Pei Lee, Ta-Hsin Tsung, Yu-Chien Tsai, Yi-Hao Chen, Da-Wen Lu   +4 more
doaj   +1 more source

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Molecular Neurodegeneration, 2011
Background Tissue plasminogen activator (tPA) exerts multiple functions in the central nervous system, depending on the partner with which it interacts. In particular, tPA acts as a positive neuromodulator of N-methyl-D-aspartate glutamatergic receptors (
Maubert Eric, Monaghan Daniel T, Jane David E, Lesept Flavie, Orset Cyrille, Montagne Axel, Jullienne Amandine, Vivien Denis, Ali Carine   +8 more
doaj   +1 more source

Changes in intracellular pH associated with glutamate excitotoxicity [PDF]

, 1993
Zachary Hartley, JM Dubinsky
openalex   +1 more source

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio, Reilly, James, Shu, Xinhua, Tiano, Luca, Tohari, Ali Mohammad, Zhang, Xun, Zhou, Xinzhi   +6 more
core   +1 more source