Results 141 to 150 of about 95,867 (358)

Optimized Long‐TE 1H sLASER MR Spectroscopic Imaging at 3T for Separate Quantification of Glutamate and Glutamine in Glioma

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Glutamate and glutamine are critical metabolites in gliomas, each serving distinct roles in tumor biology. Separate quantification of these metabolites using in vivo MR spectroscopy (MRS) at clinical field strengths (≤ 3T) is hindered by their molecular similarity, resulting in overlapping, hence indistinguishable, spectral peaks ...
Seyma Alcicek, Michael W. Ronellenfitsch, Joachim P. Steinbach, Andrei Manzhurtsev, Dennis C. Thomas, Katharina J. Weber, Vincent Prinz, Marie‐Thérèse Forster, Elke Hattingen, Ulrich Pilatus, Katharina J. Wenger   +10 more
wiley   +1 more source

Apoptosis in substantia nigra following developmental striatal excitotoxic injury. [PDF]

, 1994
Alfons Macaya, Francina Munell, Ruth M. Gubits, Robert E. Burke   +3 more
openalex   +1 more source

IMPACTS OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (TPA) ON NEURONAL SURVIVAL

Frontiers in Cellular Neuroscience, 2015
Tissue-type plasminogen activator (tPA) a serine protease is constituted of five functional domains through which it interacts with different substrates, binding proteins and receptors.
Arnaud eChevilley, Flavie eLesept, Sophie eLenoir, Carine eAli, Jérôme eParcq, Denis eVivien   +5 more
doaj   +1 more source

Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity

Aging Cell, 2016
Caloric restriction (CR) protects against many cerebral pathological conditions that are associated with excitotoxic damage and calcium overload, although the mechanisms are still poorly understood.
Ignácio Amigo, S. L. Menezes‐Filho, L. Luévano‐Martínez, B. Chausse, A. Kowaltowski   +4 more
semanticscholar   +1 more source

Molecular‐Informed Network Analysis Unveils Fatigue‐Related Functional Connectivity in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Fatigue in Parkinson's disease (PD) is a prevalent and debilitating non‐motor symptom. Despite its significant impact on quality of life, the underlying neurochemical and network‐based mechanisms remain poorly understood. Objectives This observational study applied a multimodal imaging approach to explore potential links between the
Ilaria Antonella Di Vico, Manuela Moretto, Agnese Tamanti, Giovanni Tomelleri, Giulia Burati, Daniel Martins, Ottavia Dipasquale, Mattia Veronese, Alessandra Bertoldo, Elisa Menini, Angela Sandri, Sarah Ottaviani, Francesca Benedetta Pizzini, Michele Tinazzi, Marco Castellaro   +14 more
wiley   +1 more source

Neural Mechanisms of Object Location Memory in Huntington's Disease

Movement Disorders, EarlyView.
ABSTRACT Background Object‐location memory impairment in Huntington's disease (HD) occurs from premanifest period and declines as HD progresses, however, pathogenesis of object‐location memory is unknown. The striatum and hippocampus are affected in HD, functionally interacting allowing intact object‐location memory.
Yifat Glikmann‐Johnston, Garance Delagneau, Tamrin Barta, Julie C. Stout, Adeel Razi   +4 more
wiley   +1 more source

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid [PDF]

, 1993
M. F. Beal, Emmanuel Brouillet, BG Jenkins, RJ Ferrante, N. W. Kowall, JM Miller, Elsdon Storey, Rachana Srivastava, BR Rosen, B. T. Hyman   +9 more
openalex   +1 more source

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

INCREASED CSF-LEVELS OF EXCITOTOXIC AMINO-ACIDS AFTER FULL-TERM PERINATAL ASPHYXIA [PDF]

, 1992
Mais Blennow, Henrik Hagberg, Eva Thomberg, Klara Thiringer, I Kjellmer, Hugo Lagercrantz   +5 more
openalex   +1 more source

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source