Results 151 to 160 of about 46,919 (266)

Regulation of L-Lactate in Glutamate Excitotoxicity Under Cerebral Ischemia: Pathophysiology and Preventive Strategy. [PDF]

Pharmaceuticals (Basel)
Zhang M, Wang Y, Gong Z, Jiang W, Ge G, Guo H.   +5 more
europepmc   +1 more source

Minocycline, a Tetracycline Derivative, Is Neuroprotective against Excitotoxicity by Inhibiting Activation and Proliferation of Microglia [PDF]

, 2001
Tiina Tikka, Bernd L. Fiebich, Gundars Goldsteins, Riitta Keinänen, Jari Koıstınaho   +4 more
openalex   +1 more source

Bioequivalence of a Donepezil/Memantine 10/20 mg Fixed‐Dose Combination Versus Single‐Component Tablets in Healthy Korean Males

Clinical Pharmacology in Drug Development, Volume 14, Issue 9, Page 710-716, September 2025.
Abstract A fixed‐dose combination (FDC) tablet formulation of donepezil/memantine (10/20 mg) was developed to improve medication compliance in patients with Alzheimer's disease (AD). This study compared the pharmacokinetic (PK) characteristics and safety profiles of an FDC formulation (donepezil/memantine [10/20 mg]) and single components (SCs) of ...
Minkyu Choi, Byung Hak Jin, Do Hoon Keum, Kyoung Hoon Mo, Min Soo Park, Juhwan Lee, Sungjin Park, Choon Ok Kim   +7 more
wiley   +1 more source

Neuroprotective Effect of Mixed Mushroom Mycelia Extract on Neurotoxicity and Neuroinflammation via Regulation of ROS-Induced Oxidative Stress in PC12 and BV2 Cells. [PDF]

Cells
Lee SS, Ko DH, Lee GY, Kim SY, Han SY, Park JY, Park M, Kim HM, Kim YE, Yoo YC.   +9 more
europepmc   +1 more source

Excitotoxicity is Required for Induction of Oxidative Stress and Apoptosis in Mouse Striatum by the Mitochondrial Toxin, 3-Nitropropionic Acid

, 2000
Gyung Whan Kim, Jean‐Christophe Copin, Makoto Kawase, Sylvia F. Chen, Shuzo Sato, Glenn T. Gobbel, Pak H. Chan   +6 more
openalex   +1 more source

Oxidative Glutamate Toxicity Can Be a Component of the Excitotoxicity Cascade [PDF]

, 2001
D Schubert, Dana Piasecki
openalex   +1 more source

Excitotoxicity and Glaucoma

, 2014
Yukitoshi Izumi, Takeshi Yoshitomi, Makoto Ishikawa   +2 more
openaire   +3 more sources

Polyphenols and Alzheimer's Disease: A Review on Molecular and Therapeutic Insights With In Silico Support

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
Polyphenols, known for their antioxidant and anti‐inflammatory properties, show strong potential in mitigating Alzheimer's disease by targeting oxidative stress, neuroinflammation, amyloid‐beta aggregation, and tau hyperphosphorylation. Preclinical and in silico studies highlight compounds like resveratrol, curcumin, and epigallocatechin gallate for ...
Guifei Chen, Yan Su, Siyu Chen, Tiandong Lin, Xueying Lin   +4 more
wiley   +1 more source

Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain [PDF]

, 2001
Vincent Laudenbach, Girolamo Calò, Remo Guerrini, G Lamboley, Jean‐François Benoist, Philippe Evrard, Pierre Gressèns   +6 more
openalex   +1 more source

Glial Versus Neuronal Na+ /K+ ‐ATPase in Activity‐Evoked K+ Clearance and Their Sensitivity to Elevated Extracellular K+

Glia, Volume 73, Issue 9, Page 1805-1816, September 2025.
Main Points The glial Na+ pump regulates [K+]o during neuronal activity and the neuronal version restores [K+]o to baseline. Spreading depression‐related rise of K+ does not cause SD propagation via suppression of Na+/K+‐ATPase or glutamate transport. ABSTRACT Neuronal activity in the central nervous system is associated with a [K+]o transient that is ...
Brian Skriver Nielsen, Brian Roland Larsen, Afnan Bilal Ghazal, Adriana Katz, K. C. Brennan, Steven J. D. Karlish, Nanna MacAulay   +6 more
wiley   +1 more source