Results 151 to 160 of about 90,697 (359)
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Spinal cord injury (SCI) triggers secondary damage, including pain‐induced hypertension, inflammation, and hemorrhage, impairing recovery. This study evaluated the efficacy of general anesthesia with preemptive propofol administration in mitigating secondary damage in SCI rats. SCI was induced in rats using a contusion model.
Qun Cheng +2 more
wiley +1 more source
Obesity as a Risk Factor for Alzheimer’s Disease: Implication of Leptin and Glutamate
Frontiers in Neuroscience, 2019 Obesity is known to induce leptin and insulin resistance. Leptin is a peptide hormone synthesized in adipose tissue that mainly regulates food intake.
Ana Lloret +4 more
doaj +1 more source
Aging Cell, 2016 Caloric restriction (CR) protects against many cerebral pathological conditions that are associated with excitotoxic damage and calcium overload, although the mechanisms are still poorly understood.
Ignácio Amigo +4 more
semanticscholar +1 more source
Apoptosis in substantia nigra following developmental striatal excitotoxic injury. [PDF]
, 1994 Alfons Macaya +3 more
openalex +1 more source
Relevance of Gap Junctions and Large Pore Channels in Traumatic Brain Injury
Frontiers in Physiology, 2014 In case of traumatic brain injury (TBI), occurrence of central nervous tissue damage is frequently aligned with local modulations of neuronal and glial gap junction channel expression levels.
Nora eProchnow
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is essential in treating pediatric acute lymphoblastic leukemia (ALL) but is limited by hypersensitivity reactions in up to 70% of patients, leading to severe, dose‐limiting complications and compromised event‐free survival. Procedure This study conducted a genome‐wide association study (GWAS) in a discovery cohort of
Spencer J. Anderson +10 more
wiley +1 more source
IMPACTS OF TISSUE-TYPE PLASMINOGEN ACTIVATOR (TPA) ON NEURONAL SURVIVAL
Frontiers in Cellular Neuroscience, 2015 Tissue-type plasminogen activator (tPA) a serine protease is constituted of five functional domains through which it interacts with different substrates, binding proteins and receptors.
Arnaud eChevilley +5 more
doaj +1 more source
Alcohol, Excitotoxicity and Adult Brain Damage: An Experimentally Unproven Chain-of-Events
Frontiers in Molecular Neuroscience, 2016 It has been claimed over the years—most recently in this journal and several others—that neuronal degeneration in adult brain arising during chronic alcohol exposure is, or is likely to be, via “excitotoxicity” (Chandrasekar, 2013; Mehta et al., 2013 ...
M. Collins, E. Neafsey
semanticscholar +1 more source
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid [PDF]
, 1993 M. F. Beal +9 more
openalex +1 more source
Small Structures, EarlyView.Herein, the reinforcement of bioactive hydrogels with frog‐derived neuroregenerative peptide (FRNP) is presented to create multifunctional materials with injectability, thermosensitivity, and neurorepair capabilities. The formation of a porous, dual‐network hydrogel structure, combined with the action of FRNP, promotes the proliferation, migration, and
Zhengang Sun +9 more
wiley +1 more source