Results 151 to 160 of about 82,251 (326)

Full‐Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open‐Label Study

Journal of Paediatrics and Child Health, EarlyView.
ABSTRACT Aim The aim of this Phase I/II open‐label study was to assess the safety and efficacy of NTI164, a novel full‐spectrum medicinal cannabis plant extract 0.08% Δ‐9‐tetrahydrocannabinol (THC), in Rett syndrome (RTT). Methods Eleven female participants (5–16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving
B. A. Keating, Y. Ogru, T. G. Duthy, L. Douglas, K. Lichkus, E. Isikgel, M. C. Fahey, C. Ellaway   +7 more
wiley   +1 more source

Ceftriaxone Preserves Glutamate Transporters and Prevents Intermittent Hypoxia-Induced Vulnerability to Brain Excitotoxic Injury

, 2014
Rekha Jagadapillai, Nicholas Mellen, Leroy R. Sachleben, Evelyne Gozal   +3 more
openalex   +2 more sources

Improving Kv7 targeting anticonvulsants ‐ will repurposing save the day?

British Journal of Pharmacology, EarlyView.
Nikita Gamper
wiley   +1 more source

Wallerian-like axonal degeneration in the optic nerve after excitotoxic retinal insult: an ultrastructural study [PDF]

, 2010
Sarabjit Kaur Saggu, Hiren P Chotaliya, Peter Blumbergs, Robert J. Casson   +3 more
openalex   +1 more source

Targeting pain and inflammation: A comparative study of photobiomodulation with 532 and 660 nm lasers in rats

Photochemistry and Photobiology, EarlyView.
This study evaluated the analgesic and inflammatory modulation effect of PBM using 660 nm (red) and 532 nm (green) lasers in a rat model of postoperative pain. Wistar rats underwent paw incision and received laser irradiation according to their groups.
Andréa Ribeiro Mattoso‐Câmara, Juliana Zampoli Boava Papini, Marcos Aurélio Teixeira, Denise Nami Fujii, Giovana Radomille Tofoli, Aguinaldo Silva Garcez   +5 more
wiley   +1 more source

Excitotoxicity as a molecular mechanism in Epilepsy [PDF]

, 2018
Gizem Dönmez, Abdullah Yalçın
openalex   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

Photochemistry and Photobiology, EarlyView.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew, Alan R. Harvey, Vincent P. Wallace, Stuart I. Hodgetts   +3 more
wiley   +1 more source

The role of glutamate excitotoxicity and neuroinflammation in depression and suicidal behavior: focus on microglia cells

, 2015
Gianluca Serafini, Mario Amore, Zoltán Rihmer   +2 more
openalex   +1 more source

The role of orexin A in the pathogenesis of ischaemic stroke at high altitude

Experimental Physiology, EarlyView.
Schematic illustration of the experimental design. This study investigated the role of Orexin A in the pathogenesis of ischemic stroke at high altitude. Abstract Orexin offers protection against cerebral ischaemia–reperfusion injury, with high altitude playing a key role in modulating its expression.
Minxia Zhu, Xu Guo, Jing Guo, Zhaojun Zhang, Kexin Zhang, Yaqi Lei, Yuhe Wang, Haoshuang Zhan   +7 more
wiley   +1 more source

Ouabain‐induced hypertension in rats: Mechanisms, variability and translational implications

Experimental Physiology, EarlyView.
Abstract Ouabain‐induced hypertension is a multifactorial and condition‐dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺‐ATPase, particularly the α2‐isoform, leading to elevated intracellular Ca2⁺, enhanced vasoconstriction and structural ...
Priscilla Rodrigues O. Feijó, Luis Eduardo M. Quintas   +1 more
wiley   +1 more source