Results 151 to 160 of about 95,867 (358)
The Olivocerebellar Projection Mediates Ibogaine-Induced Degeneration of Purkinje Cells: A Model of Indirect, Trans-Synaptic Excitotoxicity [PDF]
, 1997 Elizabeth O’Hearn, Mark E. Molliver
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Obesity, EarlyView.Abstract Objective Fat taste sensitivity has been implicated in long‐term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients. Methods Obesity‐induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform ...
Arnaud Bernard +5 more
wiley +1 more source
PsyCh Journal, EarlyView.ABSTRACT Deficits in schizophrenia are linked to abnormalities in the glutamate (Glu) system, which are believed to result in neurological soft signs (NSS) and negative symptoms. This study investigated the relationship between Glu levels of the anterior cingulate cortex (ACC) and NSS, particularly sensory integration, in individuals with high and low ...
Yun‐Ru Wang +12 more
wiley +1 more source
Excitotoxicity: An Organized Crime at The Cellular Level
, 2017 Excitotoxicity is a form of neuronal death induced by increased Glutamate (Glu) signaling which has been implicated in the pathophysiology of a myriad of neuropsychiatric conditions, such as dementia, motor disorders and epilepsy, among many others.
M. Velasco +8 more
semanticscholar +1 more source
Astrocyte Lipid Droplet Dynamics Orchestrate Neurological Disorders and Therapeutic Horizons
Small Science, EarlyView.This review examines astrocyte lipid droplet (LD) metabolism in neurological disorders, including Alzheimer's disease, stroke, epilepsy, and glioma. It analyzes regulatory mechanisms governing LD formation, transport, and degradation in astrocytes, highlighting their potential as biomarkers and therapeutic targets through integrative multiomics ...
Jiani Zhong +4 more
wiley +1 more source
Narrow temporal therapeutic window for NMDA antagonist protection against focal cerebral ischaemia
Neurobiology of Disease, 1995 N-methyl-d-aspartate (NMDA) receptor antagonists have been shown to protect against focal cerebral ischaemia when administered either before or soon after the onset of ischaemia.
Gary K. Steinberg +5 more
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Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells.
Journal of Pharmacological Sciences, 2020 L. Iovino +2 more
semanticscholar +1 more source
Small Methods, EarlyView.A highly innovative and implementable diagnostic tool for profiling microenvironmental perturbations in TBI patients by analyzing sEVs derived from glial cells circulating in the blood. This device provides a window into the injured brain and identifies neuroinflammatory signals, potentially serving as a platform for detecting highly specific brain ...
Zhen Zhang +10 more
wiley +1 more source
AMPA receptor desensitization predicts the selective vulnerability of cerebellar Purkinje cells to excitotoxicity [PDF]
, 1995 JR Brorson +3 more
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Age dependent sensitivity of the rat retina to the excitotoxic action ofN-methyl-D-aspartate
Neurobiology of Disease, 1995 We have found that the rat retina can be isolated atraumatically and incubatedex vivofor up to 24 h without showing signs of histological deterioration, and that retinas from adult or aged rats can be isolated as successfully as those from immature rats.
Yukitoshi Izumi +7 more
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