Results 161 to 170 of about 76,705 (331)

Prasinezumab: A Bayesian Perspective on Its Efficacy

Movement Disorders, Volume 40, Issue 4, Page 619-624, April 2025.
Mirella Russo, Tommaso Costa, Dario Calisi, Stefano L. Sensi   +3 more
wiley   +1 more source

ω-Agatoxin IVA and excitotoxicity in cortical neuronal cultures

, 1996
Heather S. Lustig, Kristine von B. Ahern, David A. Greenberg   +2 more
openalex   +1 more source

Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells [PDF]

, 2000
Manus W. Ward, A. Cristina Rego, Bruno G. Frenguelli, David G. Nicholls   +3 more
openalex   +1 more source

Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice

British Journal of Pharmacology, Volume 182, Issue 11, Page 2466-2486, June 2025.
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment options. ALS pathogenesis involves intricate processes within motor neurons, characterized by dysregulated Ca2+ influx and buffering in early ALS‐affected motor neurones. This study proposes the modulation of ryanodine receptors (
Laura Moreno‐Martinez, Núria Gaja‐Capdevila, Laura Mosqueira‐Martín, Mireia Herrando‐Grabulosa, Laura Rodriguez‐Gomez, Klaudia Gonzalez‐Imaz, Ana C. Calvo, Maialen Sagartzazu‐Aizpurua, Leticia Moreno‐García, Jose Manuel Fuentes, Abraham Acevedo‐Arozena, Jesús María Aizpurua, José Ignacio Miranda, Adolfo López de Munain, Ainara Vallejo‐Illarramendi, Xavier Navarro, Rosario Osta, Francisco Javier Gil‐Bea   +17 more
wiley   +1 more source

NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase [PDF]

, 2000
Allen S. Mandir, Marc F. Poitras, Adam R. Berliner, W. Joseph Herring, Daniel Guastella, Alicia B. Feldman, Guy G. Poirier, Zhao‐Qi Wang, Ted M. Dawson, Valina L. Dawson   +9 more
openalex   +1 more source

Tetrahedral Framework Nucleic Acid‐Based Delivery of DJ‐1‐saRNA Prevent Retinal Ischaemia–Reperfusion Injury via Inhibiting Ferroptosis

Cell Proliferation, EarlyView.
Illustration of the preparation of tFNAs‐DJ‐1 saRNAs complex and its inhibitory effects on ferroptosis in R28 and retina. ABSTRACT Retinal ischaemia/reperfusion injury (RI/RI) is the primary pathophysiological mechanism underlying retinal ischaemic diseases, potentially resulting in significant and irreversible visual impairment.
Xianggui Zhang, Zhende Deng, Xiaoxiao Xu, Jingyi Zhu, Zhen Huang, Ya Ye, Jingying Liu, Delun Luo, Jinnan Liu, Ming Yan, Yanping Song   +10 more
wiley   +1 more source

STAT3 and NFκB Activation Precedes Glial Reactivity in the Excitotoxically Injured Young Cortex but not in the Corresponding Distal Thalamic Nuclei [PDF]

, 2000
Laia Acarín, Berta Gonzແlez, Bernardo Castellano   +2 more
openalex   +1 more source

Neuroprotection for neonatal hypoxic–ischemic encephalopathy: A review of novel therapies evaluated in clinical studies

Developmental Medicine &Child Neurology, Volume 67, Issue 5, Page 591-599, May 2025.
Hypoxic‐ischemic encephalopathy (HIE) is a neurologic condition that is caused by insufficient oxygen and blood flow to a newborn infant’s brain. Although therapeutic hypothermia can reduce the degree of brain injury in some infants with HIE, many infants with HIE will have significant lifelong disabilities despite receiving this treatment.
Natalie H. Chan, Cheryl C. Hawkins, Benjamin V. Rodrigues, Marie‐Coralie Cornet, Fernando F. Gonzalez, Yvonne W. Wu   +5 more
wiley   +1 more source

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

, 1997
Hideaki Hara, Robert M. Friedlander, Valeria Gagliardini, Cenk Ayata, Klaus Fink, Zhihong Huang, Masao Shimizu‐Sasamata, Junying Yuan, Michael A. Moskowitz   +8 more
openalex   +1 more source

The influence of excitotoxic basal ganglia lesions on motor performance in the common marmoset [PDF]

, 2000
A. L. Kendall
openalex   +1 more source