Small Structures, EarlyView.Herein, the reinforcement of bioactive hydrogels with frog‐derived neuroregenerative peptide (FRNP) is presented to create multifunctional materials with injectability, thermosensitivity, and neurorepair capabilities. The formation of a porous, dual‐network hydrogel structure, combined with the action of FRNP, promotes the proliferation, migration, and
Zhengang Sun +9 more
wiley +1 more source
Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field [PDF]
, 1999 David Virley +10 more
openalex +1 more source
Chinese Clinical Practice Guidelines for Auditory Neuropathy (gCAN)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Auditory neuropathy (AN) is an auditory disorder that affects the function of the auditory pathway. An increasing number of AN cases have been identified with the revelation of the underlying mechanisms, the advancements of diagnostic and detecting techniques.
Chinese Multi‐Center Research Collaborative Group on Clinical Diagnosis and Intervention of Auditory Neuropathy; Editorial Board of Chinese Journal of Otorhinolaryngology Head and Neck Surgery; Society of Otorhinolaryngology Head and Neck Surgery +43 more
wiley +1 more source
Neuronal Death and Blood–Brain Barrier Breakdown after Excitotoxic Injury Are Independent Processes [PDF]
, 1999 Zu‐Lin Chen +5 more
openalex +1 more source
Role of NRP1/HDAC4/CREB/RIPK1 Axis in SARS‐CoV2 S1 Spike Subunit‐Induced Neuronal Toxicity
FASEB BioAdvances, EarlyView.Extracellular SARS‐CoV2 Spike‐S1 protein via NRP1 internalizes in the cytosol of SH‐SY5Y cells. Once inside, it upregulates the epigenetic eraser HDAC4, which binds transcriptional factor CREB, causes RIPK1 up‐regulation, and therefore necroptotic cell death.
Luca Sanguigno +8 more
wiley +1 more source
Regulation of System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e-\u3c/sup\u3e by Pharmacological Manipulation of Cellular Thiols [PDF]
, 2015 The cystine/glutamate exchanger (system xc-) mediates the transport of cystine into the cell in exchange for glutamate. By releasing glutamate, system xc- can potentially cause excitotoxicity.
Albano, Rebecca +4 more
core +1 more source
Mechanism of Ammonia‐Induced Brain Damage in Chinese Striped‐Necked Turtle (Mauremys sinensis)
Integrative Zoology, EarlyView.High levels of ammonia disrupt the integrity of the brain barrier in Mauremys sinensis, leading to tissue edema. This, in turn, triggers a series of cascade reactions, including disturbances in neurotransmitter levels, particularly glutamate, which might further exacerbate the neurotoxic effects.
Yunjuan Xiao +6 more
wiley +1 more source
Does Lithium Lower the Risk of Glaucoma—A Danish Nationwide Study
Acta Psychiatrica Scandinavica, EarlyView.ABSTRACT Background Glaucoma is an optic neuropathy caused by neurodegenerative loss of retinal ganglion cells (RGC). Mechanisms that contribute to RGC death include some of the same mechanisms involved in bipolar disorders (BD) and are the same mechanisms which are targeted by lithium (Li).
Tomas Hajek +5 more
wiley +1 more source
Excitotoxicity, Synaptic Repair, and Functional Recovery in the Mammalian Cochlea: A Review of Recent Findings [PDF]
, 1999 Rémy Pujol, Jean‐Luc Puel
openalex +1 more source
Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?
Acta Ophthalmologica, EarlyView.Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs +12 more
wiley +1 more source