Results 171 to 180 of about 95,867 (358)

Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo [PDF]

, 1995
Jörg B. Schulz, RT Matthews, BG Jenkins, RJ Ferrante, Donald Siwek, DR Henshaw, P. Ben Cipolloni, Patrizia Mecocci, NW Kowall, BR Rosen   +9 more
openalex   +1 more source

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System x\u3csub\u3ec\u3c/sub\u3e\u3csup\u3e−\u3c/sup\u3e Mediates Aglycemic Neuronal Cell Death [PDF]

, 2015
The astrocyte cystine/glutamate antiporter (system xc−) contributes substantially to the excitotoxic neuronal cell death facilitated by glucose deprivation. The purpose of this study was to determine the mechanism by which this occurred.
He, Yan, Hewett, James A., Hewett, Sandra J., Jackman, Nicole A., Lobner, Doug, Thorn, Trista L.   +5 more
core   +1 more source

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

Neuron, 1996
J. Rothstein, M. Dykes‐Hoberg, C. Pardo, L. Bristol, Lin Jin, R. Kuncl, Y. Kanai, M. Hediger, Yanfeng Wang, Jerry P Schielke, D. Welty   +10 more
semanticscholar   +1 more source

CCR5 predicts neurotoxicity in CAR‐T‐cell therapy

British Journal of Haematology, EarlyView.
Patients undergoing chimeric antigen receptor T (CAR T)‐cell therapy are at risk of developing immune effector cell‐associated neurotoxicity syndrome (ICANS). We observed an upregulation of CCR5 and CCR2 expression in CD4+ T cells among patients who developed ICANS.
Ayal Rozenberg, Shahar Shelly, Raz Winer, Riva Fineman, Shani Haller, Shimrit Ringelstein‐Harlev, Israel Henig, Dana Yehudai‐Ofir, Tsila Zuckerman, Tamar Tadmor, Reut Harel, Esther Ganelin‐Cohen, Ofrat Beyar‐Katz   +12 more
wiley   +1 more source

A Transforming Growth Factor-β Antagonist Unmasks the Neuroprotective Role of This Endogenous Cytokine in Excitotoxic and Ischemic Brain Injury [PDF]

, 1999
Antonio Ruocco, Olivier Nicole, Fabián Docagne, Carine Ali, Laureut Chazalviel, Sylviane Komesli, F. Yablonsky, Simon Roussel, Eric T. MacKenzie, Denis Vivien, Alain Buisson   +10 more
openalex   +1 more source

MPTP-induced degeneration: interference with glutamatergic toxicity [PDF]

, 1994
Parkinson's disease (PD) is characterised by the progressive degeneration of nigrostriatal dopamine (DA) neurons resulting in the major symptoms of akinesia and rigidity.
Lange, Klaus W., Löschmann, P. A., Turski, L., Wachtel, H.   +3 more
core  

Excitotoxicity in Perinatal Brain Injury

Brain Pathology, 2005
Excitotoxicity is an important mechanism involved in perinatal brain injuries. Glutamate is the major excitatory neurotransmitter, and most neurons as well as many oligodendrocytes and astrocytes possess receptors for glutamate. Perinatal insults such as hypoxia‐ischemia, stroke, hypoglycemia, kernicterus, and trauma can disrupt synaptic function ...
openaire   +3 more sources

Tetrahedral Framework Nucleic Acid‐Based Delivery of DJ‐1‐saRNA Prevent Retinal Ischaemia–Reperfusion Injury via Inhibiting Ferroptosis

Cell Proliferation, EarlyView.
Illustration of the preparation of tFNAs‐DJ‐1 saRNAs complex and its inhibitory effects on ferroptosis in R28 and retina. ABSTRACT Retinal ischaemia/reperfusion injury (RI/RI) is the primary pathophysiological mechanism underlying retinal ischaemic diseases, potentially resulting in significant and irreversible visual impairment.
Xianggui Zhang, Zhende Deng, Xiaoxiao Xu, Jingyi Zhu, Zhen Huang, Ya Ye, Jingying Liu, Delun Luo, Jinnan Liu, Ming Yan, Yanping Song   +10 more
wiley   +1 more source

Neonatal hypoxic-ischemic or excitotoxic striatal injury results in a decreased adult number of substantia nigra neurons

, 1992
Robert E. Burke, Alfons Macaya, D. C. DeVivo, Nicholas J. Kenyon, Eileen Janec   +4 more
openalex   +1 more source

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

Lancet Neurology, 2016
Á. Chamorro, U. Dirnagl, X. Urra, A. Planas   +3 more
semanticscholar   +1 more source