Primary CA1 and conditionally immortal MHP36 cell grafts restore conditional discrimination learning and recall in marmosets after excitotoxic lesions of the hippocampal CA1 field [PDF]
, 1999 David Virley +10 more
openalex +1 more source
Distinct peripheral pro‐inflammatory profile associated with tuberous sclerosis complex and epilepsy
Epilepsia, EarlyView.Abstract Objective Tuberous sclerosis complex (TSC) is a monogenetic disorder associated with sustained mechanistic target of rapamycin (mTOR) activation, leading to heterogeneous clinical manifestations. Epilepsy and renal angiomyolipoma are the most important causes of morbidity in adult people with TSC (pwTSC).
Renaud Balthazard +16 more
wiley +1 more source
Age dependent sensitivity of the rat retina to the excitotoxic action ofN-methyl-D-aspartate
Neurobiology of Disease, 1995 We have found that the rat retina can be isolated atraumatically and incubatedex vivofor up to 24 h without showing signs of histological deterioration, and that retinas from adult or aged rats can be isolated as successfully as those from immature rats.
Yukitoshi Izumi +7 more
doaj
Neuronal Death and Blood–Brain Barrier Breakdown after Excitotoxic Injury Are Independent Processes [PDF]
, 1999 Zu‐Lin Chen +5 more
openalex +1 more source
Spinal Cord Trauma: An Overview of Normal Structure and Function, Primary and Secondary Mechanisms of Injury, and Emerging Treatment Modalities [PDF]
, 2018 The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within.
Morin, Daniel
core +1 more source
A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat
Epilepsia, EarlyView.Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo +6 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Degeneration of hilar mossy cells in the dentate gyrus is an important hallmark of hippocampal sclerosis and is often observed in patients with temporal lobe epilepsy. To understand the pathogenesis of hippocampal sclerosis and develop novel neuroprotective treatments, it is critical to determine the mechanistic processes of mossy ...
Carolin Christina Koretz +5 more
wiley +1 more source
Excitotoxicity in Perinatal Brain Injury
Brain Pathology, 2005 Excitotoxicity is an important mechanism involved in perinatal brain injuries. Glutamate is the major excitatory neurotransmitter, and most neurons as well as many oligodendrocytes and astrocytes possess receptors for glutamate. Perinatal insults such as hypoxia‐ischemia, stroke, hypoglycemia, kernicterus, and trauma can disrupt synaptic function ...
openaire +3 more sources