Results 181 to 190 of about 82,251 (326)

Astrocytic Expression of CTMP Following an Excitotoxic Lesion in the Mouse Hippocampus [PDF]

, 2017
Nara Shin, Min‐Hee Yi, Sena Kim, Hyunjung Baek, Ursula L. Triantafillu, Jongsun Park, Dong Woon Kim   +6 more
openalex   +1 more source

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice

Glia, Volume 74, Issue 2, February 2026.
Lrp4+ astrocytes, uniquely vessel‐associated and GFAP−, are enriched in the pia. They support laminin‐α5+ basement membrane assembly and regulate vessel diameter and blood flow. They are reduced in 5xFAD brains, and their ablation worsens both vascular and Aβ pathology.
Emily Arzola, Gefei Yu, Lei Xiong, Daehoon Lee, Anika Wu, Shriya Paruchuri, Jasmine Skinner, Minghui Wang, Bin Zhang, Lin Mei, Wen‐Cheng Xiong   +10 more
wiley   +1 more source

Extracellular Vesicles from iPSC-Derived Glial Progenitor Cells Prevent Glutamate-Induced Excitotoxicity by Stabilising Calcium Oscillations and Mitochondrial Depolarisation. [PDF]

Cells
Shedenkova M, Gurianova A, Krasilnikova I, Sudina A, Karpulevich E, Maksimov Y, Samburova M, Guguchkin E, Nefedova Z, Babenko V, Frolov D, Savostyanov K, Fatkhudinov T, Goldshtein D, Bakaeva Z, Salikhova D.   +15 more
europepmc   +1 more source

Hippocampal slice preparation in rats acutely suppresses immunoreactivity of microtubule-associated protein (Map2) and glycogen levels without affecting numbers of glia or levels of the glutamate transporter VGlut1 [PDF]

, 2017
Aarts, Barry, Bortolotto, Buddle, Chang, Dienel, Farley, Fiala, Folkerts, Garthwaite, Hoskison, Hutchins, Izumi, Kirov, Kitagawa, Kuhn, Kwei, Lein, Leonard, Lipton, Lobo, Lynch, Matesic, McIlwain, Melo, Nikonenko, Pettigrew, Sajikumar, Sanchez, Sanchez-Mendoza, Santos, Schurr, Schwartzkroin, Stein, Suzuki, Villers, Wang, Watson, Wender, Whittingham   +39 more
core   +2 more sources

TNF-α triggers rapid membrane insertion of Ca2+ permeable AMPA receptors into adult motor neurons and enhances their susceptibility to slow excitotoxic injury

, 2012
Hong Yin, Cheng-I Hsu, Stephen Yu, Shyam Rao, Linda S. Sorkin, John H. Weiss   +5 more
openalex   +2 more sources

Neuroprotection with Melatonin and the Caspase-2 Inhibitor TRP601: Novel Aspects by Analysis of the Metabolome in Excitotoxic Brain Injury [PDF]

, 2011
Matthias Keller, David Enot, Mark P. Hodson, Leslie Schwendimann, Pierre Gressèns   +4 more
openalex   +1 more source

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, Volume 74, Issue 1, January 2026.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source

Altered Inflammatory Signature in a C9ORF72 ‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, Volume 74, Issue 1, January 2026.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Metabolic toxicity and neurological dysfunction in methylmalonic acidemia: from mechanisms to therapeutics. [PDF]

Mol Med
Du M, Li M, Wu S, Wu X, Chen Y, Zhu C.
europepmc   +1 more source

Room E, 10/16/2000 2: 00 PM - 4: 00 PM (PS) Dexmedetomidine Protects Against Neonatal Excitotoxic Brain Injury  [PDF]

, 2000
Vincent Laudenbach, Jean Mantz, Philippe Eurard, Pierre Gressèns   +3 more
openalex   +1 more source