Results 11 to 20 of about 46,919 (266)
Calcium Permeable-AMPA Receptors and Excitotoxicity in Neurological Disorders
Frontiers in Neural Circuits, 2021 Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the central and peripheral nervous systems. Other than the previously established signaling pathways of excitotoxicity, which depend on the excessive release of ...
Changyong Guo, Yao-Ying Ma, Yao-Ying Ma
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Insulin Protects Cortical Neurons Against Glutamate Excitotoxicity
Frontiers in Neuroscience, 2019 Glutamate excitotoxicity is implicated in the pathogenesis of numerous diseases, such as stroke, traumatic brain injury, and Alzheimer’s disease, for which insulin resistance is a concomitant condition, and intranasal insulin treatment is believed to be ...
Irina Krasil’nikova +10 more
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Frontiers in Neuroscience, 2021 Excitotoxicity has been implicated in many neurological disorders and is a leading cause of oxidative stress and neuroinflammation in the nervous system.
Kathleen F. Holton
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eLife, 2019 Overproduction of reactive oxygen species (ROS) is known to mediate glutamate excitotoxicity in neurological diseases. However, how ROS burdens can influence neural circuit integrity remains unclear.
Jhan-Jie Peng +5 more
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Glutamate Scavenging as a Neuroreparative Strategy in Ischemic Stroke
Frontiers in Pharmacology, 2022 Stroke is the second highest reason of death in the world and the leading cause of disability. The ischemic stroke makes up the majority of stroke cases that occur due to the blockage of blood vessels. Therapeutic applications for ischemic stroke include
Oykum Kaplan-Arabaci +6 more
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Ibrain, EarlyView., 2023 Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective degeneration of upper and lower motor neurons. Leucine‐rich repeats and sterility α mutations in motif 1 (LRSAM1) has been proven to be involved in the pathogenesis of ALS.
Ji‐Yao Qin +6 more
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Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy
Frontiers in Molecular Neuroscience, 2022 Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal ...
Shuang Chen +5 more
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NMDA receptor antagonists as potential therapy in cerebellar degenerative disorders
Анналы клинической и экспериментальной неврологии, 2022 Cerebellar degeneration remains a poorly studied topic. Excitotoxicity, i.e. neuronal damage and death due to excess activation of postsynaptic N-methyl-D-aspartate receptors (NMDAR) by glutamate, is considered to be a universal mechanism of most ...
Olga S. Belozor +3 more
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The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific
Frontiers in Neuroscience, 2019 Retinal ganglion cells (RGCs) are the only output neurons that conduct visual signals from the eyes to the brain. RGC degeneration occurs in many retinal diseases leading to blindness and increasing evidence suggests that RGCs are susceptible to various ...
Ian Christensen +10 more
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Mechanism of Zinc Excitotoxicity: A Focus on AMPK
Frontiers in Neuroscience, 2020 Over the last 20 years, it has been shown that complex signaling cascades are involved in zinc excitotoxicity. Free zinc rapidly induces PKC activation, which causes reactive oxygen species (ROS) production at least in part through NADPH oxidase. It also
Yang-Hee Kim, Jae-Won Eom, Jae-Young Koh
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