Results 11 to 20 of about 90,697 (359)

The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation

Frontiers in Molecular Neuroscience, 2023
Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine ...
Genhao Fan, Menglin Liu, Jia Liu, Yuhong Huang   +3 more
doaj   +1 more source

Restoration of Sarco/Endoplasmic Reticulum Ca2+-ATPase Activity Functions as a Pivotal Therapeutic Target of Anti-Glutamate-Induced Excitotoxicity to Attenuate Endoplasmic Reticulum Ca2+ Depletion

Frontiers in Pharmacology, 2022
Glutamate-induced excitotoxicity is a pathological basis of many acute/chronic neurodegenerative diseases. Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2b) is a membrane-embedded P-type ATPase pump that manages the translocation of calcium ions (Ca2 ...
Wen Zhang, Wen Zhang, Wen Zhang, Fanghua Ye, Nan Pang, Nan Pang, Nan Pang, Miriam Kessi, Miriam Kessi, Miriam Kessi, Miriam Kessi, Juan Xiong, Juan Xiong, Juan Xiong, Shimeng Chen, Shimeng Chen, Shimeng Chen, Jing Peng, Jing Peng, Jing Peng, Li Yang, Li Yang, Li Yang, Fei Yin, Fei Yin, Fei Yin   +25 more
doaj   +1 more source

A Small Natural Molecule S3 Protects Retinal Ganglion Cells and Promotes Parkin-Mediated Mitophagy against Excitotoxicity

Molecules, 2022
Glutamate excitotoxicity may contribute to retinal ganglion cell (RGC) degeneration in glaucoma and other optic neuropathies, leading to irreversible blindness.
Dongli Zhuang, Rong Zhang, Haiyang Liu, Yi Dai   +3 more
doaj   +1 more source

Various facets of excitotoxicity

Exploration of Neuroprotective Therapy, 2022
Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the central nervous system, it is also the most common ...
Talita Glaser, Jean Bezerra Silva, Guilherme A. Juvenal, Pedro Negrão Maiolini, Natalia Turrini, Lyvia Lintzmaier Petiz, Lucas Bonfim Marques, Deidiane Elisa Ribeiro, Qing Ye, Yong Tang, Henning Ulrich   +10 more
doaj   +1 more source

Molecular mechanisms of NMDA excitotoxicity in the retina

Scientific Reports, 2023
NMDA excitotoxicity, as a part of glutamate excitotoxicity, has been proposed to contribute significantly to many retinal diseases. Therefore, understanding mechanisms of NMDA excitotoxicity will provide further insight into the mechanisms of many ...
Galina Dvoriantchikova, Michelle Fleishaker, Dmitry Ivanov   +2 more
doaj   +1 more source

Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells

Frontiers in Cellular Neuroscience, 2020
A plethora of neurological disorders shares a final common deadly pathway known as excitotoxicity. Among these disorders, ischemic injury is a prominent cause of death and disability worldwide.
Denisa Belov Kirdajova, J. Kriska, J. Tureckova, M. Anděrová   +3 more
semanticscholar   +1 more source

Loss of tumor necrosis factor (TNF)‐receptor 1 and TNF‐receptor 2 partially replicate effects of TNF deficiency on dendritic spines of granule cells in mouse dentate gyrus

Journal of Comparative Neurology, Volume 531, Issue 2, Page 281-293, February 2023., 2023
Hippocampal granule cells of adult mice lacking canonical TNF‐Rs were filled with Alexa568 and immunolabeled for Synaptopodin. Morphometric analysis of their spines revealed that TNF‐R mutants partially replicate changes previously reported for TNF‐deficient mice.
Dinko Smilovic, Michael Rietsche, Meike Fellenz, Alexander Drakew, Mario Vuksic, Thomas Deller   +5 more
wiley   +1 more source

Functional consequences of brain exposure to saturated fatty acids: From energy metabolism and insulin resistance to neuronal damage

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Saturated fatty acids induce insulin resistance in neurons. Neuronal metabolism of palmitic acid alters mitochondrial function. Abstract Introduction Saturated fatty acids (FAs) are the main component of high‐fat diets (HFDs), and high consumption has been associated with the development of insulin resistance, endoplasmic reticulum stress and ...
Karina Sánchez‐Alegría, Clorinda Arias   +1 more
wiley   +1 more source

Synaptic NMDA receptors mediate hypoxic excitotoxic death [PDF]

, 2012
Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia.
Wroge, Christine M, Hogins, Joshua, Eisenman, Larry, Mennerick, Steven   +3 more
core   +3 more sources

Excitotoxicity: Still Hammering the Ischemic Brain in 2020

Frontiers in Neuroscience, 2020
Interest in excitotoxicity expanded following its implication in the pathogenesis of ischemic brain injury in the 1980s, but waned subsequent to the failure of N-methyl-D-aspartate (NMDA) antagonists in high profile clinical stroke trials.
D. Choi
semanticscholar   +1 more source