The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific
Frontiers in Neuroscience, 2019 Retinal ganglion cells (RGCs) are the only output neurons that conduct visual signals from the eyes to the brain. RGC degeneration occurs in many retinal diseases leading to blindness and increasing evidence suggests that RGCs are susceptible to various ...
Ian Christensen +10 more
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Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis [PDF]
, 2017 Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability.
A Banjac +110 more
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Mechanism of Zinc Excitotoxicity: A Focus on AMPK
Frontiers in Neuroscience, 2020 Over the last 20 years, it has been shown that complex signaling cascades are involved in zinc excitotoxicity. Free zinc rapidly induces PKC activation, which causes reactive oxygen species (ROS) production at least in part through NADPH oxidase. It also
Yang-Hee Kim, Jae-Won Eom, Jae-Young Koh
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Targeting CDK5 in Astrocytes Promotes Calcium Homeostasis Under Excitotoxic Conditions
Frontiers in Cellular Neuroscience, 2021 Glutamate excitotoxicity triggers overactivation of CDK5 and increases calcium influx in neural cells, which promotes dendritic retraction, spine loss, increased mitochondrial calcium from the endoplasmic reticulum, and neuronal death.
Luisa Fernanda Toro-Fernández +8 more
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Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]
, 2003 Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic ...
Alvarez, Dalia +3 more
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Tau exacerbates excitotoxic brain damage in an animal model of stroke
Nature Communications, 2017 Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Mian Bi +18 more
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Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration
Cell Reports, 2019 Summary: Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. In this study, we provide in vivo evidence that this spatial specificity is lost in Shiverer (Shi) mice, a model for progressive ...
Dinesh C. Joshi +8 more
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Hyperacute Excitotoxic Mechanisms and Synaptic Dysfunction Involved in Traumatic Brain Injury
Frontiers in Molecular Neuroscience, 2022 The biological response of brain tissue to biomechanical strain are of fundamental importance in understanding sequela of a brain injury. The time after impact can be broken into four main phases: hyperacute, acute, subacute and chronic. It is crucial to
Brendan Hoffe, Matthew R. Holahan
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Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons [PDF]
, 2016 Perinatal Asphyxia (PA) represents an important cause of severe neurological deficits including delayed mental and motor development, epilepsy, major cognitive deficits and blindness.
Barreto, George E. +5 more
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Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity
Molecules, 2014 The accumulation of glutamate can excessively activate the N-methyl-d-aspartate (NMDA) receptors and cause excitotoxicity. Daphnetin (Dap), a coumarin derivative, is a protein kinase inhibitor that exhibits antioxidant and neuroprotective properties ...
Le Yang +7 more
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