Results 21 to 30 of about 46,919 (266)
Tau exacerbates excitotoxic brain damage in an animal model of stroke
Nature Communications, 2017 Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Mian Bi +18 more
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Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity
Molecules, 2014 The accumulation of glutamate can excessively activate the N-methyl-d-aspartate (NMDA) receptors and cause excitotoxicity. Daphnetin (Dap), a coumarin derivative, is a protein kinase inhibitor that exhibits antioxidant and neuroprotective properties ...
Le Yang +7 more
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Cellular and Molecular Pathophysiology of Traumatic Brain Injury: What Have We Learned So Far?
Biology, 2023 Traumatic brain injury (TBI) is one of the leading causes of long-lasting morbidity and mortality worldwide, being a devastating condition related to the impairment of the nervous system after an external traumatic event resulting in transitory or ...
Marco Aurelio M. Freire +5 more
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Parkinson's Disease, 2016 A serendipitous pharmacogenetic finding links the vulnerability to developing levodopa-induced dyskinesia to the age of onset of Huntington’s disease. Huntington’s disease is caused by a polyglutamate expansion of the protein huntingtin.
Svetlana A. Ivanova, Anton J. M. Loonen
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Antioxidants, 2020 This study aimed to compare the antioxidant activities of extracts obtained from three plant families and evaluate their therapeutic effect on strokes.
Narayana Pineda-Ramírez +8 more
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Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration
Cell Reports, 2019 Summary: Syntaphilin (SNPH) is a major mitochondrial anchoring protein targeted to axons and excluded from dendrites. In this study, we provide in vivo evidence that this spatial specificity is lost in Shiverer (Shi) mice, a model for progressive ...
Dinesh C. Joshi +8 more
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Bioenergetics and glutamate excitotoxicity
Progress in Neurobiology, 1996 Bioenergetic defects and abnormalities in glutamate neurotransmission have both been proposed to play important roles in neurological diseases of varying chronology, etiology and pathology. Recent experimental evidence suggests an intimate relationship between these two systems.
Greenamyre Jt, Greene Jg
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Excitotoxicity and Neuroprotection
The Journal of Clinical Psychiatry, 1997 Issue: Excitatory neurotransmission is a normal physiologic process mediated by the neurotransmitter glutamate. Too much glutamate release can be destructive and literally excite a neuron to death in a process called excitotoxicity. Blocking this process may be neuroprotective and prevent brain disorders mediated by excitotoxicity.
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FTY720 attenuates excitotoxicity and neuroinflammation [PDF]
Journal of Neuroinflammation, 2015 FTY720 (fingolimod, Gilenya™), a structural analog of sphingosine-1-phosphate (S1P), is the first oral drug approved for treatment the relapsing-remitting form of multiple sclerosis (MS), and its efficacy has been related to induced lymphopenia and consequent immunosuppression via modulation of S1P1 receptors (S1P1R).
Cipriani, Raffaela +3 more
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Frontiers in Cellular Neuroscience, 2022 Hepatic encephalopathy (HE)–a major complication of liver disease–has been found to increase the risk of olfactory dysfunction, which may be attributed to elevated levels of ammonia/ammonium in the blood and cerebrospinal fluid.
Mingxian Li +8 more
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