Results 31 to 40 of about 90,697 (359)
International Journal of Cancer, Volume 152, Issue 5, Page 998-1012, 1 March 2023., 2023 What's new? The spatial distribution of glioma is nonrandom. However, whether pathological grade influences glioma distribution across the brain remains unclear. Here, the authors built a population‐based frequency map for 396 patients with glioblastoma multiforme and 190 patients with lower‐grade glioma, revealing their distinct topographic ...
Hongbo Bao +10 more
wiley +1 more source
Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity
Frontiers in Neuroscience, 2020 Excitotoxicity is classically attributed to Ca2+ influx through NMDA receptors (NMDAr), leading to production of nitric oxide by neuronal nitric oxide synthase and superoxide by mitochondria, which react to form highly cytotoxic peroxynitrite.
Jie-jie Wang, R. Swanson
semanticscholar +1 more source
Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. [PDF]
, 2017 Glutamate is the dominant excitatory neurotransmitter in the brain, but under conditions of metabolic stress it can accumulate to excitotoxic levels.
Andreyev, Alexander Y +12 more
core +1 more source
JCPP Advances, Volume 2, Issue 4, December 2022., 2022 Sex differences in ADHD have not been adequately considered, particularly for studies of fractional anisotropy (FA), a measure of white matter microstructural development. Results here demonstrate that ADHD symptom domains are differentially related to FA, highlighting the multi‐componential nature of the disorder.
Scott A. Jones +3 more
wiley +1 more source
Exploration of the glutamate-mediated retinal excitotoxic damage: a rat model of retinal neurodegeneration [PDF]
International Journal of Ophthalmology, 2018 AIM: To explore the more suitable concentration of glutamate or N-methyl-D-aspartic acid (NMDA) for intravitreal injection to establish a rat model of retinal neurodegeneration.
Ling Gao +6 more
doaj +1 more source
Mechanism of Zinc Excitotoxicity: A Focus on AMPK
Frontiers in Neuroscience, 2020 Over the last 20 years, it has been shown that complex signaling cascades are involved in zinc excitotoxicity. Free zinc rapidly induces PKC activation, which causes reactive oxygen species (ROS) production at least in part through NADPH oxidase. It also
Yang-Hee Kim, Jae-Won Eom, J. Koh
semanticscholar +1 more source
Lithium from mood stabilizer to putative cognitive enhancer [PDF]
, 2016 This study is the first to have demonstrated, by means of a highly sensitive test of visual memory, a potential hippocampus neuroprotective effect of lithium in patients with BD. Undoubtedly, other studies are needed to finally recognize lithium as a
Bersani, Giuseppe +2 more
core +2 more sources
Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity
Molecules, 2014 The accumulation of glutamate can excessively activate the N-methyl-d-aspartate (NMDA) receptors and cause excitotoxicity. Daphnetin (Dap), a coumarin derivative, is a protein kinase inhibitor that exhibits antioxidant and neuroprotective properties ...
Le Yang +7 more
doaj +1 more source
Nature Communications, 2018 Mutations in C9ORF72 are the most common cause of familial amyotrophic lateral sclerosis (ALS). Here, through a combination of RNA-Seq and electrophysiological studies on induced pluripotent stem cell (iPSC)-derived motor neurons (MNs), we show that ...
B. Selvaraj +33 more
semanticscholar +1 more source
Absence of system xc⁻ on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis [PDF]
, 2017 Background: Multiple sclerosis (MS) is an autoimmune demyelinating disease that affects the central nervous system (CNS), leading to neurodegeneration and chronic disability.
A Banjac +110 more
core +2 more sources