Results 61 to 70 of about 46,919 (266)

TrkB-ICD Fragment, Originating From BDNF Receptor Cleavage, Is Translocated to Cell Nucleus and Phosphorylates Nuclear and Axonal Proteins

Frontiers in Molecular Neuroscience, 2019
The signaling of brain-derived neurotrophic factor (BDNF) has been suggested to be impaired in Alzheimer’s disease (AD), which may compromise the function of BDNF upon neuronal activity and survival.
João Fonseca-Gomes, João Fonseca-Gomes, André Jerónimo-Santos, André Jerónimo-Santos, Angelina Lesnikova, Plinio Casarotto, Eero Castrén, Ana M. Sebastião, Ana M. Sebastião, Maria J. Diógenes, Maria J. Diógenes   +10 more
doaj   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

AAV‐Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone‐Induced Demyelination

Glia, EarlyView.
AAV‐BDNF improves cognitive performance after cuprizone‐induced de‐myelination. BDNF promotes OPC maturation and enhances remyelination in the corpus callosum. Mitochondrial integrity is preserved through reduced swelling and improved morphology. ABSTRACT Multiple sclerosis (MS) is a chronic neurological disorder involving immune‐mediated demyelination
Yousra El Ouaamari, Leonardo Ricciardi, Sanne van der Heijden, Antonia Peter, Jorrit De Waele, Jasper Van den Bos, Debby Van Dam, Elke Calus, Sarah Kuhn, Waleed Marei, Yvonne Dombrowski, Marleen Verhoye, Peter Ponsaerts, Inez Wens, Nathalie Cools   +14 more
wiley   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, EarlyView.
Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons during rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic lipids and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production of ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

Neuromodulatory Effect of Thymoquinone in Attenuating Glutamate-Mediated Neurotoxicity Targeting the Amyloidogenic and Apoptotic Pathways

Frontiers in Neurology, 2018
Overexposure of the glutamatergic N-methyl-d-aspartate (NMDA) receptor to the excitatory neurotransmitter l-glutamic acid leads to neuronal cell death by excitotoxicity as a result of increased intracellular Ca2+, mitochondrial dysfunction, and apoptosis.
Ibram Amin Fouad, Nadia Mohamed Sharaf, Ragwa Mansour Abdelghany, Nesrine Salah El Dine El Sayed   +3 more
doaj   +1 more source

Selective Deletion of NBCe1 in Reactive Astrocytes Attenuates Ischemic Stroke Brain Damage

Glia, EarlyView.
NBCe1 is upregulated in reactive astrocytes following ischemic stroke. Deletion of astrocytic Nbce1 reduces stroke volume, preserves AQP4 polarization, reduces BBB permeability, and improves neurological function after ischemic stroke. ABSTRACT The electrogenic sodium bicarbonate transporter 1 (NBCe1/Slc4a4), predominantly expressed in astrocytes, is ...
Okan Capuk, Elise Berthold, Kathiravan Kaliyappan, Mansi Avunoori, Rajesh Muduganti, Sanjana Krishna, Shamseldin Metwally, Mary McFarland, Shanshan Song, Victoria Fiesler, Sydney Fischer, Lesley M. Foley, T. Kevin Hitchens, Susannah Waxman, Ian A. Sigal, Shefeeq M. Theparambil, Gulnaz Begum   +16 more
wiley   +1 more source

Mitochondria and neuronal glutamate excitotoxicity

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1998
The role of mitochondria in the control of glutamate excitotoxicity is investigated. The response of cultured cerebellar granule cells to continuous glutamate exposure is characterised by a transient elevation in cytoplasmic free calcium concentration followed by decay to a plateau as NMDA receptors partially inactivate. After a variable latent period,
David G. Nicholls, Samantha L. Budd
openaire   +2 more sources

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, EarlyView.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source

Neuroprotective Mechanisms of Lycium barbarum Polysaccharides Against Ischemic Insults by Regulating NR2B and NR2A Containing NMDA Receptor Signaling Pathways

Frontiers in Cellular Neuroscience, 2017
Glutamate excitotoxicity plays an important role in neuronal death after ischemia. However, all clinical trials using glutamate receptor inhibitors have failed.
Zhongshan Shi, Zhongshan Shi, Zhongshan Shi, Zhongshan Shi, Lihui Zhu, Lihui Zhu, Lihui Zhu, Lihui Zhu, Tingting Li, Xiaoya Tang, Yonghui Xiang, Xinjia Han, Luoxing Xia, Ling Zeng, Junhua Nie, Yongxia Huang, Yongxia Huang, Chi Kwan Tsang, Ying Wang, Zhigang Lei, Zaocheng Xu, Kwok-fai So, Kwok-fai So, Kwok-fai So, Kwok-fai So, Yiwen Ruan, Yiwen Ruan, Yiwen Ruan, Yiwen Ruan   +28 more
doaj   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source