Results 61 to 70 of about 95,867 (358)

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides

Frontiers in Cellular Neuroscience, 2015
The microtubule-associated axonal specification collapsin response mediator protein 2 (CRMP2) is a novel target for neuroprotection. A CRMP2 peptide (TAT-CBD3) conjugated to the HIV transactivator of transcription (TAT) protein’s cationic cell ...
Aubin eMoutal, Liberty eFrancois-Moutal, Joel M Brittain, May eKhanna, Rajesh eKhanna   +4 more
doaj   +1 more source

CXCL12-induced neurotoxicity critically depends on NMDA receptor-gated and L-type Ca2+ channels upstream of p38 MAPK. [PDF]

, 2016
BackgroundThe chemokine receptor CXCR4 (CD184) and its natural ligand CXCL12 contribute to many physiological processes, including decisions about cell death and survival in the central nervous system.
Kaul, Marcus, Maung, Ricky, Medders, Kathryn E, Ojeda-Juárez, Daniel, Sanchez, Ana B, Sánchez-Pavón, Paloma   +5 more
core   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Apolipoprotein E expression is elevated by interleukin 1 and other interleukin 1-induced factors

Journal of Neuroinflammation, 2011
Background We have previously outlined functional interactions, including feedback cycles, between several of the gene products implicated in the pathogenesis of Alzheimer's disease.
Liu Ling, Aboud Orwa, Jones Richard A, Mrak Robert E, Griffin W Sue T, Barger Steven W   +5 more
doaj   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Bechmann, Ingo Jürgen, Dehghani, Faramarz, Ehrlich, Angela, Geisslinger, Gerd, Hobusch, Constance, Kallendrusch, Sonja, Koch, Marco, Nowicki, Marcin, Ziebell, Simone   +8 more
core   +3 more sources

Rational Design of Inner Ear Drug Delivery Systems

Advanced Science, EarlyView.
Hearing loss is a common disease affecting many people, and inner ear lesions are one of the most important causes. This review focuses on the treatment of inner ear hearing loss by drug delivery systems. It includes the current methods and technologies developed, and it predicts possible directions.
Xiayidan Maimaitikelimu, Zhiyan Xuan, Haoyu Ren, Keng Chen, Hui Zhang, Huan Wang   +5 more
wiley   +1 more source

Targeting Polyamine Oxidase to Prevent Excitotoxicity-Induced Retinal Neurodegeneration

Frontiers in Neuroscience, 2019
Dysfunction of retinal neurons is a major cause of vision impairment in blinding diseases that affect children and adults worldwide. Cellular damage resulting from polyamine catabolism has been demonstrated to be a major player in many neurodegenerative ...
Prahalathan Pichavaram, Prahalathan Pichavaram, Chithra Devi Palani, Chithra Devi Palani, Chithra Devi Palani, Chintan Patel, Chintan Patel, Zhimin Xu, Zhimin Xu, Esraa Shosha, Esraa Shosha, Abdelrahman Y. Fouda, Abdelrahman Y. Fouda, Ruth B. Caldwell, Ruth B. Caldwell, Ruth B. Caldwell, Subhadra Priya Narayanan, Subhadra Priya Narayanan, Subhadra Priya Narayanan, Subhadra Priya Narayanan, Subhadra Priya Narayanan   +20 more
doaj   +1 more source

The spectrum of Ischemia-induced white matter injury varies with age [PDF]

, 2013
Stroke is a neurological condition that targets the whole range of the human population, from the pre-term infant to the elderly and is a major cause of death worldwide (Ingall 2004).
Muscat, Richard, Valentino, Mario, Zammit, Christian   +2 more
core   +1 more source

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity

Molecular Neurobiology, 2018
Neuronal excitotoxicity which is induced by exposure to excessive extracellular glutamate is shown to be involved in neuronal cell death in acute brain injury and a number of neurological diseases.
Plamena R. Angelova, D. Vinogradova, M. Neganova, T. Serkova, Vladimir V. Sokolov, S. Bachurin, E. Shevtsova, A. Abramov   +7 more
semanticscholar   +1 more source