Results 161 to 170 of about 21,092 (247)

Targeted liquid chromatography–tandem mass spectrometry profiling of arginine and histidine derivatives in chronic migraine: Discriminatory performance and changes after onabotulinumtoxinA therapy

Headache: The Journal of Head and Face Pain, EarlyView.
Plain Language Summary People with chronic migraine may have changes in amino‐acid metabolism, but it remains unclear which metabolic pathways are associated with the disease and early response to onabotulinumtoxinA treatment. We measured plasma amino‐acid levels in patients with chronic migraine and healthy controls and assessed changes after 1 month ...
Seyma Dumur, Kadidiatou Diarra, Joudy Sewidan, Julie Jalila Kalmoni, Demet Aygun, Dildar Konukoglu, Hafize Uzun   +6 more
wiley   +1 more source

Compound exocytosis of granules in human neutrophils.

, 2002
Human neutrophils are of prime importance for the immune defense. Recent data from eosinophils and pancreatic beta cells have indicated that granules, upon exocytosis, occasionally fuse with each other in the cytosol prior to their subsequent fusion with
Lollike, K., Lindau, M., Calafat, J., Borregaard, N.   +3 more
core  

The Role of Neuropeptide Y in Dental Pulp: Balancing Neurogenic Inflammation and Pain Modulation

International Endodontic Journal, EarlyView.
ABSTRACT Background Dental pulp is a densely innervated, low‐compliance tissue in which neurogenic inflammation can rapidly escalate into oedema, raised intrapulpal pressure, microvascular compromise, and pain. While Substance P (SP) and Calcitonin gene‐related peptide (CGRP) are well‐established drivers of pulp vasodilation, the Neuroopeptide Y (NPY ...
Javier Caviedes‐Bucheli, Esteban Ulate, Hugo‐Roberto Munoz, Nestor Ríos‐Osorio   +3 more
wiley   +1 more source

The Psoriasis–Eczema Interface: Clinical Classification and Therapeutic Implications From a Bicentric Experience

International Journal of Dermatology, EarlyView.
The psoriasis–atopic dermatitis interface: four clinical phenotypes (coexisting, overlapping, biologic‐induced eczema, dupilumab‐induced psoriasis) across 105 patients from two Italian tertiary centers. JAK inhibitors achieved the highest response rates across all phenotypes, reflecting their mechanistic rationale targeting shared JAK‐STAT downstream ...
Michela D'Agostino, Gennaro Marco Falco, Eleonora De Luca, Clara De Simone, Alessandro Di Stefani, Maddalena Napolitano, Ketty Peris, Matteo Megna, Giacomo Caldarola   +8 more
wiley   +1 more source

Dilution‐Endpoint Comparison of a Flow Cytometric Platelet Activation Assay With PF4/Heparin ELISA and a Lateral Flow Immunoassay in Suspected HIT

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Heparin‐induced thrombocytopenia (HIT) is a rare but potentially life‐threatening, immune‐mediated adverse reaction to heparin. PF4‐dependent immunoassays are sensitive screening tests, but they detect both platelet‐activating and nonactivating antibodies; therefore, positive results require interpretation in clinical context and,
Elvira Maličev, Matjaž Urbajs, Katerina Jazbec Gradišar, Ana Kolenc, Primož Rožman   +4 more
wiley   +1 more source

Ovarian Cancer‐Associated Ascites Accumulates NK Lymphocytes Displaying a Transcriptomic Profile Consistent With the Immature/Secretory CD56bright Subtype

Immunology &Cell Biology, EarlyView.
NK cells present in EOC‐associated ascites retain elements of the conventional NK cell program while displaying a transcriptional profile distinct from peripheral blood NK cells. This profile encompasses biological programs usually associated with the CD56bright NK cell functions, which is consistent with transcriptional remodeling rather than complete
Caroline Natânia de Souza‐Araújo, Glenerson Baptista, Gabriela Rapozo Guimarães, Raissa Carolina Alves da Silva, Adriana Yoshida, Cláudia Rodrigues Tonetti, José Andrés Yunes, Daniela Maira Cardoso, Sophie Derchain, Mariana Boroni, Fernando Guimarães   +10 more
wiley   +1 more source

Myo1g Mediates NKR‐P1C Expression in Primary Mouse NK Cells and Participates in Cytotoxicity

Immunology, EarlyView.
In this study we analysed the participation of Myosin 1g in the development and functions of murine natural killer (NK) cells; we found that Myosin 1g is expressed in murine‐activated primary NK cells from the spleen. Additionally, in the absence of Myosin 1g, correlates with a reduced expression of NKR‐P1C but not of CD49b or NKp46.
Héctor Romero‐Ramírez, Vania Aminta Zuleica López‐Esparza, Mariana Flores‐Castelán, Leopoldo Santos‐Argumedo   +3 more
wiley   +1 more source

Chronic silencing of subsets of cortical layer 5 pyramidal neurons has a long‐term influence on the laminar distribution of parvalbumin interneurons and the perineuronal nets

Journal of Anatomy, Volume 246, Issue 4, Page 479-504, April 2025.
Chronic silencing of subsets of layer 5 projection neurons has distinct effects on the laminar distribution of PV interneurons and the perineuronal nets in the adult primary motor and somatosensory cortex. Abstract Neural networks are established throughout cortical development, which require the right ratios of glutamatergic and GABAergic neurons ...
Florina P. Szabó, Veronika Sigutova, Anna M. Schneider, Anna Hoerder‐Suabedissen, Zoltán Molnár   +4 more
wiley   +1 more source

TipQuant: a robust algorithm for quantitative analysis of spatiotemporally dynamic activities in tip‐growing cells

New Phytologist, EarlyView.
Tip Quantification enables quantitative analyses over versatile selections of regions of interest. Summary Cell polarity and tip growth rely on the dynamic spatial organization of signaling and structural components. Quantitative characterization of these spatiotemporal dynamics is critical for understanding polarized cell growth, yet manual ...
Jingzhe Guo, Julian Le Gouic, Rémi Rosenthal, Ailing Zou, Xiang Zhou, Nicolas Brunel, Zhenbiao Yang, Xinping Cui   +7 more
wiley   +1 more source

Identification of Critical Amino Acid Residues Required for the Polar Localization of a Rice Manganese Transporter

Plant Biotechnology Journal, EarlyView.
ABSTRACT Rice has developed an efficient system for manganese (Mn) uptake, mediated by two distinct transporters, OsNramp5 and OsMTP9. These transporters exhibit polar localization at the root exodermis and endodermis; however, the mechanisms underlying their polar localization and their role in Mn uptake remain unclear.
Noriyuki Konishi, Jian Feng Ma
wiley   +1 more source